However The Rough Pricing Starts At 490€ Per Assay/per Marker For Plucked Hair Analysis Goes Further

[bekeero]

INVITROHAIR
http://www.invitrohair.com/
admin
I have been communicating with the company about how to treat /
What do you think about this treatment?
Good morning dear Ahmed,

we- normally- work only with pharmaceutical companies and ABHRS / ISHRS fellowship doctors.

If you haven’t chosen a hair surgeon, you maybe can tell us if you’re willing to travel to our laboratory or clinic, otherwise we’re happy to refer you to one good surgeon in your area.

If you want a so-called personalized treatment you must travel either to our laboratory or clinic. It starts at 490€ for plucked out hair analysis and can end at >75.000€ if you’ve for example a Hamilton- Norwood scale 7 hairloss total treatment. The price per „cloned“ hairfollicle is 12€.

Please be advised that with our invention you’re not limited to donor area available Hairfollicles anymore since we can grow them indefinitely.

However the rough pricing starts at 490€ per assay/per marker for plucked hair analysis goes further thru Dermal Papillae Stem Cell isolation, hairfollicle replication, Hairfollicle Stem Cell Banking at 250€ per year thru Insilico Screenings, to personalized Medicine treatment to hairfollicle replication for transplantation.

We prefer to know first your pathology (what is the (cellular- dna based) reason for your hairloss) before offering you a personalized strategy/price.

The easiest way is to obtain 20 plucked out hair - best with roots (10 from donor area at the back of your head - 10 from the effected area of they’re some left)to send them in a normal sterile cup tube - to our laboratory and we test them on individual pathogens. This will cost 490€ per marker.

Henceforth- and only if a further treatment is preferable- you need a surgeon to FUE extract 20 hairfollicles and send them in hypothermosol to our laboratory this will cost 690€ per marker

Alternatively we could enroll you in our clinical phases but for this we must see you in the laboratory and in our test clinic, and this will require a huge payment from your side which is not advisable at the moment. Patience is key.

We’ve as well one medical repurpose (WNT Activators) Analog in the development (it will be a pill) but we will not supply it to you before we haven’t analyzed your individual pathology.

I’ll attach a short presentation with indicative pricing.



Again, please keep in mind we are a biotechnology company developing de novo human hair transplants and a AI guided medical/cosmetic hairloss compound development company. We are happy to develop a personalized strategy for your specific pathology/ identify your specific phenotype.

We are not a FUE - best price- clinic, we’ve invented a personalized hairloss treatment strategy whereas transplantation of „cloned“ Hairfollicles are just a part of various subsequent procedures. And they’re starting with simple testings (Assays) at a modest price.

 

[disfiguredyoungman]

What does "cloned" mean in that context? A common Stem Cell treatment?

 

[bekeero]

الشركة حديثة والعلاج جديد ؛ أنا على الأرجح أن كلمة (مستنسخة) تنتمي إلى استنساخ الخلايا الجذعية! !!

 

[Sanchez1234]

What does 'per marker' mean? What exactly will they do for 490$?

 

[Fgsfds]

Soooo I can throw money at them today and they'll clone my follicles and implant them?

EDIT: Seems to me you can pay to clone them, and it's up to you to get them transplanted. They also claim to give you some WNT pills. Neat.

 

[Janks16]

This is intriguing. Don't know what to make of this.

 

[JonnyGo]

What the hell is going on here? I thought Sciseido or whatever his name is was working on hair cloning.

EDIT: I meant tsuji!

 

[max310]

Bump. I want more information on this. Is this even safe?

 

[rocket_hare]

Did some digging.

1. Follicle thought has an story on them FWIW
http://www.folliclethought.com/invitrohair-exclusive-interview/

2. They have a twitter an instagram showing off what looks like actual lab stuff so that's cool?

3. They seem to think WAY has some admirable qualities to it or at least components of it do:
"We started an #insilico screening on patentable equivalents to WAY 316606 (5-(Phenylsulfonyl)-N-4-piperidinyl-2-(trifluoromethyl)benzene sulfonamide hydrochloride) using our #patented #hairfollicle #organoid this #AI #screening includes #moleculardiversity #calculation"


Dunno what to think of them at the moment, hopefully more established sources come out to talk about them as we learn more..

 

[mdmnota]

Well wtf, is this legit?

 

[00000]

ill wait until they show us a b4 and after to make a judgement... until then its a scam.... everythings a scam.... just like makeup, plastic surgery, fake tits, fake ***, fake pussy tightening so she can say shes only been with 5 guys ... cough cough more like 50 cough...

 

[xetrys]

Second website went down (is now a redirect). I don't know, looks shady to me.

 

[Unspecified]

Follicle thought guy did an interview with them. Basically we have cure for baldness now, it's just super expensive (they charge 12€ per follicle, and on top if that you have to pay the transplant).

"We have isolated dermal papillae stem cells (DPSC) from FUE hair follicles and merged them with reprogrammed induced pluripotent stem cells. We have developed our own, patentable protocol for testing various conditions.This work has led us to obtain a fully developed denovo hair follicle, which will be autologous, thus preventing any reverse reaction or teratoma formations once the follicle has been transplanted in to the scalp.The production time, from receiving the viable hair follicle biopsies (we need between 10 and 20 hair follicles) until the fully formed hair follicle surrounded by skin tissue completed is 90 days."

Also their business model is concentrated on satisfying "the growing demand for high-quality test methods, which will gradually reduce and ultimately replace animal experimentation, for both industrial safety & efficacy testing as well as medical research", so they don`t wanna use their limited capital on super expensive approval procedures, they need partners for that.They have pretty impressive research team too.

 

[reuters]

There would have been massive news coverage if this was legit, superstars and wealthy people would have paid that money instantly for that result.

 

[Marcaronii]

Wait... so you're saying, right at this very moment this technology is already available for us as long as we have the financial resources?

 

[Undertaker]

Wait... so you're saying, right at this very moment this technology is already available for us as long as we have the financial resources?

I have the same question. Also why was there no hype about this?

 

[xetrys]

Wait... so you're saying, right at this very moment this technology is already available for us as long as we have the financial resources?

I don't think so, only if you have enough $$ to fund your place in the clinical trials yet to come (presumably end next year).

I have the same question. Also why was there no hype about this?

Hype about what exactly? We haven't seen any concrete results, just plans for the future and expensive prices imo. This doesn't seem to be something for the average person.

 

[Unspecified]

Claim is that they can clone hair follicle in 90 days, I don't think this is a scam, it's not cream, lotion or a pill for a quick cash in..
Anyway, before anybody can try this treatment there will be a ton of trials, so chill and be positive. This is first company that reach this stage in cloning, I think it's important step forward.

 

[Marcaronii]

Claim is that they can clone hair follicle in 90 days, I don't think this is a scam, it's not cream, lotion or a pill for a quick cash in..
Anyway, before anybody can try this treatment there will be a ton of trials, so chill and be positive. This is first company that reach this stage in cloning, I think it's important step forward.

Err tsuji?

 

[Gooner184]

Hi guys. I've been lurking this site for the past couple of years but this caused me to finally sign up. II've actually been talking with this company via email. I have to say they come across as very professional and reply to emails very quickly. they dont seem annoyed by me asking multiple questions and even seem to encourage it. I'm gonna post my emails exchanges between me and them below.

***First email I sent them:

Hello. I've heard about your company through a hairloss forum and have also visited your website. Am I correct in assuming that you have already developed a method to clone hair follicles meaning you can perform a hair transplant regardless of donor hair availability? I Have been following the progression of hair cloning over the past few years and have only been aware of one company(Tsuji/Riken) who have made any progress in this field. I would love some more information on this as if it is possible I would be definitely interested regardless of cost. Thanks and I look forward to hearing back from you.

***Reply I got back from them:

Good day Sir,

my name is Sergey and I’m the CSO of the company.

Firstly let me state clearly that we need minimum skin fibroblasts from the patient, and (ideally) any form of hairfollicle from the body of the patient.

(Theoretically we could use gene edited and HLA human leukocyte antigen free - in order to prevent autoimmune reactions - dermal papillae stem cells from other patients (which we have partially available)....but the genetic editing would cost a breathtaking amount of money this is our second patent - so let’s spare this for now).

Your assumption is right, we work (simultaneously) on transplantable Hairfollicles without the necessity of having cells from a patient at all...

We have fixed prototypes available- as you can see on our twitter account-

Our approach is different from the Tsuji publication - here attached-




The initial “Riken-Hairfollicle” is developed within the use of mouse vibrissae stem cells (or whiskers stems !!) / embryonic (!)stem cells and a bioengineered inter epithelial tissue PLASTIC DEVICE.

The model is fascinating and the inventor and the institute are icons but in the 2012 publication/version totally useless for human applications.; because you’ll hardly reach an GMP/GLP complaint grade within the use of non human material ...it’s a complete different approach than our patented human hairfollicle.

Our hairfollicle is engineered from merging the human patients own isolated DPSC (dermal papillae stem cells) and reprogrammed IPSC (induced pluripotent stem cells). We do not use embryonic stem cells we only use solely the patients/ adult stem cells.

Our model can be used immediately for personalized medication testing of one patients 100% identical - replicated hairfollicle-.

Our background is from disease modeling/ tissue engineering and computational AI compounds developing.

However, for you to benefit from our services- unfortunately this is not cheap, we’re fully aware of this- you have to undergo various Assays (Tests) in order for us to understand your specific pathology and in order to identify the correct phenotype of “your specific disease”.

Here you’ve a -easy to oversee- scheme:





In order to determine that your pathology is eligible for creating personalized hairfollicles we need to perform the following subsequent assays - sequences can be spared or interrupted if your pathology is contraindicated to final hairfollicle transplantation.

To participate in Assay B you theoretically need to travel to our laboratory/clinic in Europe ( in your case Luxembourg because our Paris clinic is booked till August, if you’re from overseas). If you’re from Europe we could speak to your doctor to extract 30 hairfollicles (if they’re some left)or a skin biopsy (1cm in diameter).

Here are the single steps (subsequent but as separable in sequences if necessary):


Assay A- Plucked out hair Assays pricing is around 1.470€
Assay B- FUE harvested Hairfollicle Assays pricing is around 3.450€ of fibroblasts.
DPSC isolation 4000€ per 24 well plate
Insilico compound screening for 10 available compounds 9850€
Insilico specific compound screening for example WAY 316606 ,12950€
IPSC reprogramming from your DPSC/ hairfollicle/ fibroblasts 13950€
Hairfollicles for personalized testing approach 12€ per hairfollicle
Hairfollicles for transplantation 12€ per hairfollicle - but we need to enroll you in the clinical study in late 2019 (if you’re eligible for it).

All depends on your pathology- simplified: what’s the exact problem- and the correct phenotypic engineered personalized hairfollicle. Do you have a kind of pathogenic description of your disease?

If you’ve questions or want further information do not hesitate to contact us.

Mit freundlichen Grüßen
Yours truly
Cordialment
Prof. Dr. Sergey Leonov
CSO
INVITROHAIR SA


***Second email I sent in response to their reply:

Thank you so much for the detailed reply. I’m not going to pretend I understood everything including all the technical stuff but I have a rough idea. I have a few quick questions to clarify though.

1) you said in order to be involved in this you have to enrol in the clinical trials at the end of 2019. I’m confused if this is available now or is it only the end of next year that we can have a chance to get this?

2)Have you guys treated any men with male pattern baldness at all yet or will the first application be next year.

3)For someone who is a NW6 what would you guess as a rough estimate for the entire cost for everything would be from the assays to the final transplantation(considering they are able to partake after the assays)

4)”sequences can be spared or interrupted if your pathology is contraindicated to final hairfollicle transplantation”. What would cause someone to not be able to receive this treatment. Do you reckon it would be quite rare for a man with male pattern baldness to undergo the assays and not be eligible for the treatment? It would be quite discouraging if that happened to someone I would imagine.

5) for someone with advanced baldness do you reckon after all the assays they can be treated in one transplant session. For example from a nw6 to an nw1 in one session? Or would you still need maybe multiple sessions for advanced baldness?

6) I have an advanced balding pattern but still have minaturized hairs and vellus hairs that don’t contribute at all. Would you be able to transplant through those hairs or would I have to wait till I become slick bald to receive this.

Sorry for the many questions but I am highly interested in this as I imagine quite a few others are. I look forward to your reply


***Second response I got back from them:

Good day dear Sir,

for the sake of clarity I just give straight short answers - at least I try.

Please see my answers below :

1) you said in order to be involved in this you have to enrol in the clinical trials at the end of 2019. I’m confused if this is available now or is it only the end of next year that we can have a chance to get this?

The hairfollicles are available now but we only can transplant them in the clinical trails starting end of 2019. Nevertheless we would need to apply first pathology tests and the identification of phenotypes - this applies to every patient.

2)Have you guys treated any men with male pattern baldness at all yet or will the first application be next year.

We’ve conducted various pathology and phenotypes identification. As well personalized compound screenings. (So everything from A to C) and reprogramming/ hairfollicle production. But the transplantation is only possible in a so called compassionate use experiment and we will choose the patients after analyzing the results. Nevertheless ASAP your DPSC and IPSC are isolated/reprogrammed and stored you’ve peace of mind because we’ve secured your status quo. Theoretically even you wait 2 years after the DPSC/IPSC we could transplant you henceforth indefinite amount of Hairfollicles.
Time is - unfortunately- key, but please do not consider this as a push to sell you smth. Our approach is subsequent and in sequences because of this...

3)For someone who is a NW6 what would you guess as a rough estimate for the entire cost for everything would be from the assays to the final transplantation(considering they are able to partake after the assays)

Hard to answer but a rough estimate without prejudice and given the “worse case scenario” that you go for every sequence:

Assay A- Plucked out hair Assays pricing is around 1.470€
Mandatory
Assay B- FUE harvested Hairfollicle Assays pricing is around 3.450€ of fibroblasts. Plus travel costs (depends on your location)
Mandatory

DPSC isolation 4000€ per 24 well plate
Mandatory

Insilico compound screening for 10 available compounds 9850€
Sequence depends on the earlier assay results

Insilico specific compound screening for example WAY 316606 ,12950€
Advisable but not subsequent

IPSC reprogramming from your DPSC/ hairfollicle/ fibroblasts 13950€
Mandatory

Hairfollicles for personalized testing approach 12€ per hairfollicle
Strongly advised we need maximum 500 hairfollicles.

Gene editing 20€ per hairfollicle...
Think this will be quite often the case....

Hairfollicles for transplantation 12€ per hairfollicle - but we need to enroll you in the clinical study in late 2019 (if you’re eligible for it).

If all subsequent Assays and tests are indicating you’re eligible, the price will be dependent on the amount of hairfollicle you want - ONCE WE HAVE THE DPSC isolated AND IPSC reprogrammed and STORED WE COULD PRODUCE 1.000.000 of YOUR HAIRFOLLICLES IF NECESSARY....


4)”sequences can be spared or interrupted if your pathology is contraindicated to final hairfollicle transplantation”. What would cause someone to not be able to receive this treatment.

This is not easy to answer but it could be for example a malfunction of thyroid glands, or even worse undetected blood cancer - Hodgkins Disease-, and especially autoimmunity disorders/reactions . Or your specific inherited /or elsewhere “acquired” genetic disorder. This is why you need a specific diagnosis and not jus like “ You’ve Alopecia...”

Do you reckon it would be quite rare for a man with male pattern baldness to undergo the assays and not be eligible for the treatment?

Since the hairfollicles are engineered depending on the Assays it’s very unlikely. If you’re “lucky” you probably don’t even need a transplantation because we could identify and modulate your specific condition without transplantation. This is why it’s important to test your pathology and identify the phenotype in prior.... you’ll never get this with simple FUE...


5) for someone with advanced baldness do you reckon after all the assays they can be treated in one transplant session. For example from a nw6 to an nw1 in one session?

Theoretically yes, if all indications and patients pathogenic situation is allowing it (I can imagine it’s quite a long process to implant 15.000 hairfollicles but it’s doable).

Or would you still need maybe multiple sessions for advanced baldness?

See above..

6) I have an advanced balding pattern but still have minaturized hairs and vellus hairs that don’t contribute at all. Would you be able to transplant through those hairs or would I have to wait till I become slick bald to receive this.

No, if we could harvest the hairfollicles and isolate enough DPSC (dermal papillae stem cells) it wouldn’t be a problem. Additional we could obtain a small skin biopsy for skin fibroblasts in order to reprogram IPSC (induced pluripotent stem cells) from it. So no problem if you’ve hair left (even eyebrows or beard would be enough). If you’ve no hair at all it would be challenging because we would need to gene edit a lot of isolated cells from our commercially available DPSC, but it’s doable.

Please understand that it’s absolutely personalized and correct answers could be only given after the assays are conducted.


Sorry for the many questions but I am highly interested in this as I imagine quite a few others are. I look forward to your reply

You’re very welcome,



Thats my email correspondence with them. What do you guys make of it? Ngl I dont understand all the technical jargon so maybe someone could explain it in laymans terms. they seem like they are very serious though but the price for this could be astronomical. I've also attached some files they sent me aswell in the first email reply.