Baldness Cure Possible As Scientists Re-grow Hair On Mice Using Human Stem Cells

[Joxy]

This is very important paper. For the first time ( I think) they regrown hair on mice with 100% human stem cells (iPSCs I think)

Hair-bearing human skin generated entirely from pluripotent stem cells

Whole paper: https://www.nature.com/articles/s41586-020-2352-3
Whole paper: https://www.biorxiv.org/content/10.1101/684282v1.full

George Cotsarelis also gave his review and opinion about this major discovery ( his words)
https://www.nature.com/articles/d41586-020-01568-2

This news was also covered by Mirror
https://www.mirror.co.uk/science/baldness-cure-possible-scientists-re-22132190

One of the main authors has website
https://koehler-lab.org/team

 

[John Difool]

Legend

 

[Throwaway94]

It's a shame they're looking to waste their wonderful technology on burn victims instead of the gold standard that is the hair loss market

 

[nameless2]

This may sound wild but would it be possible to have your own scalp skin removed and replaced with this skin that has healthy follicles growing lots of healthy long hairs??????

 

[sonictemples]

This may sound wild but would it be possible to have your own scalp skin removed and replaced with this skin that has healthy follicles growing lots of healthy long hairs??????

I think they already do that. They put a balloon under your donor zone, inflate it, therefore increase the surface area of the donor zone, removing the balloon and streching it over your scalp.

 

[Poppyburner]

 

[mpower]

Peak performance definitely doesn't look like this

 

[MeDK]

This is very important paper. For the first time ( I think) they regrown hair on mice with 100% human stem cells (iPSCs I think)

Hair-bearing human skin generated entirely from pluripotent stem cells

Whole paper: https://www.nature.com/articles/s41586-020-2352-3
Whole paper: https://www.biorxiv.org/content/10.1101/684282v1.full

George Cotsarelis also gave his review and opinion about this major discovery ( his words)
https://www.nature.com/articles/d41586-020-01568-2

This news was also covered by Mirror
https://www.mirror.co.uk/science/baldness-cure-possible-scientists-re-22132190

One of the main authors has website
https://koehler-lab.org/team

it have been done before. In older studies they even found out that if you want high density hair you need more blood flow into the skin or else it will die out.

But the problem with mice studies is, that they have a hard time to translate into human studies.

 

[Joxy]

it have been done before. In older studies they even found out that if you want high density hair you need more blood flow into the skin or else it will die out.

But the problem with mice studies is, that they have a hard time to translate into human studies.

Maybe you are right, but I think this is the first time someone to use 100% human stem cells (iPSCs). This is very big difference. Everyone else before used mixed human and mice cells.

George Cotsarelis quote for this discovery:

When hair follicles were first generated from stem cells that had been isolated from adult mouse skin1, Jay Leno — a former host of US talk show The Tonight Show — joked that scientists “cured baldness … at least in mice”. Sixteen years on, the current host will have the opportunity to mention that scientists have ‘cured’ baldness in humans, now that Lee et al.2, writing in Nature, have regenerated hair follicles from human stem cells. This achievement places us closer to generating a limitless supply of hair follicles that can be transplanted to the scalps of people who have thinning or no hair. Moreover, if the approach reaches the clinic, individuals who have wounds, scars and genetic skin diseases will have access to revolutionary treatments.

The later he added this:

However, several questions remain before this therapeutic approach becomes a reality. For instance, how efficiently and reproducibly do hairs develop? How many cells are needed to eventually form a hair follicle once grafted? Lee et al. began to answer the first of these questions by showing that a separate laboratory could grow hair in organoids using the same culture conditions. However, dealing with variability between individual stem cells and between the stem cells from different people are daunting challenges.

Several other aspects of the authors’ approach will also need to be optimized before it can move to the clinic. The hairs that grew in the current study were small; in future, further optimization of culture conditions will be needed to form large scalp hairs. Better characterization of some components used in the culture cocktail — such as a protein mixture called Matrigel — will be necessary to ensure that they comply with good manufacturing practices.

Despite these caveats, Lee and colleagues’ study is a major step towards a ‘cure’ for baldness in humans, and paves a way towards other, greater therapeutic possibilities. At a minimum, it is worth a shout-out on a late-night show. The work holds great promise of clinical translation — we are confident that research will eventually see this promise realized.


Even Stemson (Alexey Terskikh) used mixed human and mice cells.

https://www.eurekalert.org/pub_releases/2019-06/sbpm-fhf062519.php

“The current protocol relies on mouse epithelial cells combined with human dermal papilla cells. The experiments were conducted in immunodeficient nude mice, which lack body hair.“

I agree with you that mouse studies not always give impressive results in humans, but modern science have many other tools to verify if something is working or not. Plus, science based on mouse and animals studies gave us many incredible breakthrough discoveries last century.

One of the tools is creating human organoids from stem cells (mostly iPSCs).

https://www.sciencedirect.com/science/article/pii/B9780128191781000459

 

[doflamingo]

Cool just burn your scalp then go get this treatment

 

[Joxy]

Researchers grow hairy skin from human stem cells

“This is the first study to show that human hair can be grown completely from stem cells in a dish, which has been a goal of the skin biology community for decades,” said Karl Koehler, PhD, assistant professor of otolaryngology—head and neck surgery at Harvard Medical School and Boston Children’s Hospital.

https://medicine.iu.edu/news/2020/06/researchers-grow-hairy-skin-from-human-stem-cells

 

[John Difool]

Mice don't have Androgenetic Alopecia. What's happening when you plant these HF made from scratch on a bald scalp?

 

[Spanishboy97]

Mice don't have Androgenetic Alopecia. What's happening when you plant these HF made from scratch on a bald scalp?

Wouldnt the cells they use be from DHT resistant follicules?

 

[YanDjin]

This seems big, but is there a chance this cure reaches clinics before we are all old men ?

 

[Joxy]

This is big, but it's probably not very relevant to most of us here. Tissuse and Tsuji should work for us. This will be great for burn victims and testing new drugs.

In this study they growned hairs from 100% human stem cells (iPSCs) without using any donor hair follicles. So, yes it is big news, but they need to solve other problems in future.

 

[Joxy]

This seems big, but is there a chance this cure reaches clinics before we are all old men ?

Maybe in 10 years from now.

 

[NewUser]

Mice don't have Androgenetic Alopecia.

Some mice do. Since at least 2010. We share over 97% of our DNA with mice and had a common ancestor about 100 million years ago. And, you share about 99.9% of your DNA with every other person on the planet. Compared to black Africans, the most genetically robust human beings on earth, Caucasians are genetic hillbillies. The sun doesn't revolve around us. We aren't so special.

This is more evidence that drugs will cure baldness someday, just like there are drug candidates to re-grow specialized hearing cells which normally don't re-grow in humans - a much harder problem to solve than hair loss.

 

[mpower]

>>Compared to black Africans, the most genetically robust human beings on earth, Caucasians are genetic hillbillies. The sun doesn't revolve >>around us. We aren't so special.

I am not sure where you read this crap but this is definitely not science. There are a myriad of diseases that affect black people much more than white people. It's all a trade off and adaptation. People do really get dumber and dumber it seems. Looks like we've got a dumb *** commie here

 

[MeDK]

Some mice do. Since at least 2010. We share over 97% of our DNA with mice and had a common ancestor about 100 million years ago. And, you share about 99.9% of your DNA with every other person on the planet. Compared to black Africans, the most genetically robust human beings on earth, Caucasians are genetic hillbillies. The sun doesn't revolve around us. We aren't so special.

This is more evidence that drugs will cure baldness someday, just like there are drug candidates to re-grow specialized hearing cells which normally don't re-grow in humans - a much harder problem to solve than hair loss.

when talking about percentages 3% in difference doesn't sound like a lot. But it is when we look at the numbers.

Also if mice studies were reliable we would have cured countless diseases to this day. Diabetes wouldn't be a thing, baldness wouldn't either. But when we take all of those mice studies they simply doesn't work on humans.

The "best" mice studies are the ones where they use immune deficient mice. So they are almost sure that a transplante and foriegn organism doesn't get rejected.

Human bodies reject foreign organism, and to prevent it you give a human loads of medication to suppress your own immune system.

The best solutions to this problem in my opionon is autologous treatments, where your own cells are used so the risk of rejection is smaller. The other hurdle with that when culturing that it isn't cancer you end up culturing, which is a big risk when cloning the cells.

 

[H]

This is big, but it's probably not very relevant to most of us here. Tissuse and Tsuji should work for us. This will be great for burn victims and testing new drugs.

They "should" work too bad they dont.