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Tissue-scale tensional homeostasis in skin regulates structure and physiological function - Communications Biology
Kimura et al. reports a refined human skin equivalent (HSE) model that reproduces traction-force balance in the lateral direction. This tension improves HSE characteristics and promotes skin homeostasis. This model has great potential for applications in drug screening and understanding the...


New artificial skin functions like natural skin
Researchers at RIKEN in Japan have developed an improved human-skin equivalent that reproduces a property that controls the structure and physiological function of skin. This artificial skin will enhance in-depth analyses of physiological skin functions, provide solutions to skin problems caused...
www.eurekalert.org
30. Oktober 2020 Nachrichten:
Our recent studies provided a proof of concept regarding fully functional regeneration of tissues and organs, such as teeth, hair follicles, secretory glands and the IOS, that mimic the developmental processes of organogenesis.
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Tension-released skin was obtained from the resection of a part of contracted skin and included both epidermis and dermis, the reduction of interfollicular spaces, and vertical rearrangement of hair follicle compared with normal skin
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In skin development, tissue tension is known to regulate the cell alignment of epidermal keratinocytes and dermal fibroblasts through the combination with ECM fibres and appendages such as hair follicles and align with skin tension direction, which is called Langar’s cleavage line
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