5? Avocuta-inhibits the activity of 5 ? reductase/anti-sebum

[Jacob]

http://www.expanscience-ingredients.com/pdf/en/avocuta.pdf

http://www.expanscience-ingredients.com/products/active-ingredients/5-alpha-avocuta-hair.htm

(27 volunteers - cream containing 2% active ingredient- 3 theoritical weeks)

1. Sebum samples were taken before and after the treatment (applications twice a day) using a Sebufix® F16 patch, enabling secretion levels to be assessed. A visual examination was performed by a dermatologist (applying scores on a 1 to 5 scale) as well as a digital analysis. A reduction of 34% was recorded in this score, a mean reduction of 69% in cumulative total lipid stain surface area, thus demonstrating the reality of a sharp slowdown in the activity of the sebaceous glands.

2. Using a scoring scale of 0 to 9 and six criteria, the dermatologist assessed the condition of the volunteers' skins before and after treatment. That condition improved sharply in all cases.

3. The volunteers were able to confirm the clinical results by giving their own assessment of the effectiveness of the cream (% positive opinions):

Improvement in greasy appearance of hair: ---- 78%
Soothing effect on irritation: -------------------------- 63%
Reduction in dandruff: --------------------------------- 67%

Normal human fibroblasts are treated for 24 hours, either with Serenoa repens (a pharmaceutical active ingredient
known to inhibit 5- reductase) or with 5 Avocuta®, in the presence of radiomarked testosterone. The formation of
dihydrotestosterone (DHT) from testosterone is directly correlated to 5- reductase activity and its quantity is proportional
to the quantity of radioactivity measured.

The addition of Serenoa repens clearly reduces the activity of 5-
reductase and therefore the quantity of DHT synthesised. At the same
concentrations, 5 Avocuta® is more effective at inhibiting the activity of
5- reductase (-49% for 100 ?g/ml).

Since DHT is a powerful androgen stimulating the sebaceous glands,
5 Avocuta® appears to be an excellent active substance for improving
seborrheic conditions.

Shampoo containing 1% 5  Avocuta® applied every two days by 27 volunteers (3 weeks).

1/ The cumulative surface area of lipid spots decreased by an average of 69% (13 subjects), demonstrating a marked
slowing down of sebaceous gland activity.

2/ The seborrhea was reduced by approximately half, while the stinging,
pruritus, erythema and desquamation that frequently accompany
seborrheic conditions had practically disappeared.

3/ Lastly the volunteers confirmed these results:
- improvement of the greasy appearance of hair (78%),
- soothing effect on irritation (63%)
- reduction of dandruff (67%)

 

[Jacob]

Some products that contain it:

http://bellapielstore.com/SeSKavelHairLosshtml.html

http://www.shrdhaircare.com/shrd.html

 

[Bryan]

That's all well and good, but what does it have to do with hair loss? :dunno:

 

[Jacob]

I'm sorry...did I make some sort of claim above?

Ppl in these forums..who actually use things...are interested in ingredients/products geared towards scalp health..even sebum reduction.

 

[Bryan]

In all seriousness, you should post that over on acne.org. Those people are desperate to find something that will reduce their sebum production!

 

[Jacob]

Since you're already signed up and posting there..for whatever reason...go for it :crazy:

 

[Bryan]

Okay...I'll do it! (Although I may just direct them over here to read all that stuff.)

 

[Nex]

Arch Enemies :firing: :bigun2:

 

[Bryan]

Well, I'm still holding-off on posting on the other site, because I'm having a fair amount of trouble finding a source of this "5? Avocuta". I did find an acne product which claims to have it as an ingredient, but I'd like to have a bit more than just that. I'll try again a little later...

 

[Jacob]

http://evance.com.sg/products-acnecur.htm

http://www.isis-pharma.com/eng/catalogue/teen-derm/teen-derm-mask.html

http://energymarket.ecrater.com/p/12786681/aqua-teen-derm-lotion-oily

 

[Jacob]

Arch Enemies :firing: :bigun2:

:wow: ...I'm sure it'll be back to that the next time you-know-what gets posted :woot:

 

[DavisNY]

can this stuff be used on the scalp for oily hair? any sides?

 

[Jacob]

Well the shampoo linked to above is obviously for hair/the scalp. The acne products.. :dunno:

 

[Jacob]

BTW..if anyone stumbles upon a site that sells the sulfate and paraben-free shampoo and also the SH-RD Revive Scalp Essence..please post it. Mainly interested in knowing the ingreds list for each....

http://www.shrdhaircare.com/shrd.html

 

[Jacob]

It sounds like one will be able to order it directly from them. $20 for the shampoo and $24 for the topical. Those are the only two I inquired about..and am still waiting for the ingredients list for both.

I haven't looked if this is in any products out there: http://files.salvona.com/sebum_newsletter/TDS_MS_SebumControl.pdf

 

[Bryan]

Somebody over on acne.org who I've been talking to privately about "5a-Avocuta" has ordered a product recently that contains it. When he gets it and tries it out for a while, it'll be interesting to hear from him whether or not it appears to work!

 

[Jacob]

So you didn't post it to the board? :whistle:

 

[Bryan]

So you didn't post it to the board? :whistle:

Yes I did. I posted it to the board, AND had a private conversation with someone about it. He told me about the product he ordered that supposedly contains it.

 

[Jacob]

Yes..I see it now. You didn't direct them here though.

I don't think it's such a great idea to admit you're talking privately with someone from an acne board..probably a teenager :shock:

 

[israelite]

i cant stop laughing