This post was made by 5001Mike on another fourm. I thought it was interesting and looking for opinions on it.
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It is unreasonable to expect significant regrowth from t-flavanone. T-flavanone is a Tgf-Beta2 inhibitor, and is best used alongside a powerful antiandrogen such as Fluridil. Using these two together will completely halt hairloss and prevent fibrosis. Will it grow hair on a NW4 and above? NO. However, if you are at the early stages it looks like it's essential to use them.
1: J Dermatol Sci. 2004 Jun;35(1):9-18. Related Articles, Links
Role of TGF-beta2 in the human hair cycle.
Hibino T, Nishiyama T.
Shiseido Life Science Research Center, 2-12-1 Fukuura, Kanazawa-ku, Yokohama 236-8643, Japan. toshihiko.hibino@to.shiseido.co.jp
Male pattern baldness is the result of premature entry into catagen due to androgens. In order to prevent hair loss, it is important to understand two critical steps, i.e., the induction mechanism of premature entry and the regression process of catagen. At the initiation, dihydrotestosterone (DHT) stimulates synthesis of transforming growth factor-beta2 (TGF-beta2) in dermal papilla cells. TGF-beta2 suppresses proliferation of epithelial cells and stimulates synthesis of certain caspases. Then TGF-beta2 triggers the intrinsic caspase network and subsequently epithelial cells are eliminated through apoptotic cell death. TGF-beta antagonists are effective in preventing catagen-like morphological changes and in promoting elongation of hair follicles in vivo and in vitro. These lines of evidence strongly suggest the presence of a "catagen cascade" in male pattern baldness, involving: (1) the conversion of testosterone to DHT by type II 5-alpha-reductase; (2) the synthesis of TGF-beta2 in dermal papilla cells; and (3) the activation of the intrinsic caspase network. These sequential events contribute to the shortening of the human hair cycle. Copyright 2004 Japanese Society for Investigative Dermatology
PMID: 15194142 [PubMed - in process]
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So anyone have experiences of using T-Flav with a antiandrogen product like spironolactone, fluridil, or revivogen?
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It is unreasonable to expect significant regrowth from t-flavanone. T-flavanone is a Tgf-Beta2 inhibitor, and is best used alongside a powerful antiandrogen such as Fluridil. Using these two together will completely halt hairloss and prevent fibrosis. Will it grow hair on a NW4 and above? NO. However, if you are at the early stages it looks like it's essential to use them.
1: J Dermatol Sci. 2004 Jun;35(1):9-18. Related Articles, Links
Role of TGF-beta2 in the human hair cycle.
Hibino T, Nishiyama T.
Shiseido Life Science Research Center, 2-12-1 Fukuura, Kanazawa-ku, Yokohama 236-8643, Japan. toshihiko.hibino@to.shiseido.co.jp
Male pattern baldness is the result of premature entry into catagen due to androgens. In order to prevent hair loss, it is important to understand two critical steps, i.e., the induction mechanism of premature entry and the regression process of catagen. At the initiation, dihydrotestosterone (DHT) stimulates synthesis of transforming growth factor-beta2 (TGF-beta2) in dermal papilla cells. TGF-beta2 suppresses proliferation of epithelial cells and stimulates synthesis of certain caspases. Then TGF-beta2 triggers the intrinsic caspase network and subsequently epithelial cells are eliminated through apoptotic cell death. TGF-beta antagonists are effective in preventing catagen-like morphological changes and in promoting elongation of hair follicles in vivo and in vitro. These lines of evidence strongly suggest the presence of a "catagen cascade" in male pattern baldness, involving: (1) the conversion of testosterone to DHT by type II 5-alpha-reductase; (2) the synthesis of TGF-beta2 in dermal papilla cells; and (3) the activation of the intrinsic caspase network. These sequential events contribute to the shortening of the human hair cycle. Copyright 2004 Japanese Society for Investigative Dermatology
PMID: 15194142 [PubMed - in process]
================================================
So anyone have experiences of using T-Flav with a antiandrogen product like spironolactone, fluridil, or revivogen?
