Alcaris Therapeutics To Present At Morgan Stanley Conference

[jc3303]

http://phx.corporate-ir.net/phoenix.zhtml?c=254196&p=irol-newsArticle_Print&ID=2199605

They're presenting on Wednesday and I'm hoping for some good news on JAK inhibitors for use on Androgenetic Alopecia. There will be a live audio webcast I won't be able to catch it but hopefully someone here can.

Next week might be big for us.

 

[cratusg]

Yes because I'm confident that fidia will present the trial results for brotzu lotion this week as well since some guy from the italian forum said we can call this upcoming week and get to know how many months until release and another guy said Italian summer holiday ends 13th of September!

 

[jc3303]

I'm not so sure about news from Brotzu, maybe some one will get a couple tidbits of info from them. I hope I'm wrong tho

I'm just hoping Alcaris confirms JAK inhibitors work for Androgenetic Alopecia and they're gonna start trials soon (might be wishful thinking on my part).

 

[Admin]

We have a conference call with everyone at Aclaris in a week. I can make sure to ask any questions you guys have at that time. It sounds like the entire team including Christiano will be present on the call.

 

[jc3303]

Guys with AA I believe are in for some big news next week, I just hope they got good news for us Androgenetic Alopecia sufferers too

 

[Admin]

I just spoke to them. They will not be presenting anything regarding Their Alopecia research next week. It's primarily going to be related to new data on their wart treatment.

 

[jc3303]

We have a conference call with everyone at Aclaris in a week. I can make sure to ask any questions you guys have at that time. It sounds like the entire team including Christiano will be present on the call.

All I wanna know is if this will work for Androgenetic Alopecia, when they'll start trials and also when it could become available for purchase.

 

[Admin]

All I wanna know is if this will work for Androgenetic Alopecia, when they'll start trials and also when it could become available for purchase.

That is, for sure, the question currently on the table. It will be part of the discussion when we talk.

 

[Blackber]

That is, for sure, the question currently on the table. It will be part of the discussion when we talk.

This must be what you were alluding to in the other thread, awesome .

For a moment I thought it was going to be a follow up with Histogen.

Thanks Admin.

 

[Admin]

For a moment I thought it was going to be a follow up with Histogen.

To be completely honest, my calendar is filling up with conversations with these and several other companies. They are eager to speak, and it has been really humbling and exciting to feel such openness from them. I think any websites that keep the conversation and information flowing are serving the greater good. So I applaud everyone. And thank you to all the users who have kind of chilled out on contacting the teams directly. I think it is really starting to help. I think they want some megaphones from which to speak. And the various sites and bloggers out there are all doing a great job of playing that role.

 

[InBeforeTheCure]

We have a conference call with everyone at Aclaris in a week. I can make sure to ask any questions you guys have at that time. It sounds like the entire team including Christiano will be present on the call.

At a conference back in June, Walker said:

"We will be developing a topical JAK inhibitor for androgenetic alopecia, and the data on that is quite interesting in that they found that the systemic JAK inhibitor does not work for that particular indication, but the topical does, mainly as a function of the target being more superficial in the skin and not really accessible from a systemic circulation."

Be sure to ask him how exactly they know this before starting human trials. It can't be cultured hair follicles, because then the "systemic vs. topical" specification wouldn't make sense. The one thing that maybe makes sense is that they grafted some bald human Androgenetic Alopecia skin to mice and tested systemic vs. topical JAK inhibitors on them.

 

[jc3303]

To be completely honest, my calendar is filling up with conversations with these and several other companies. They are eager to speak, and it has been really humbling and exciting to feel such openness from them. I think any websites that keep the conversation and information flowing are serving the greater good. So I applaud everyone. And thank you to all the users who have kind of chilled out on contacting the teams directly. I think it is really starting to help. I think they want some megaphones from which to speak. And the various sites and bloggers out there are all doing a great job of playing that role.

we all applaud your efforts as well! This year has been huge for hairloss and I can't wait to see what 2017 brings

and I hope you have an interview with Replicel on your calendar, I'm very excited about their work personally

 

[Tracksterderm]

To be completely honest, my calendar is filling up with conversations with these and several other companies. They are eager to speak, and it has been really humbling and exciting to feel such openness from them. I think any websites that keep the conversation and information flowing are serving the greater good. So I applaud everyone. And thank you to all the users who have kind of chilled out on contacting the teams directly. I think it is really starting to help. I think they want some megaphones from which to speak. And the various sites and bloggers out there are all doing a great job of playing that role.

When you speak to these companies / scientists, do you ever feel or learn from them directly that they visit forums / blogs etc. to read what people write about them or generally about hairloss discussions?

 

[Admin]

When you speak to these companies / scientists, do you ever feel or learn from them directly that they visit forums / blogs etc. to read what people write about them or generally about hairloss discussions?

Truthfully I haven't had that vibe yet. Most of them are in a completely different universe. They are all in the lab. They are all buried in their work. And a lot of them are intimidated and regretful if people contact them and are upset about missed timelines/deadlines. Or if they said something that they later had to change and somebody got upset and sent them a frustrated email.

They're completely aware of all of you. I think most of them don't really know how to interact with you guys though. As many of you know, doctors and scientists aren't exactly experts in human interaction. Angela Christiano would be one solid exception to this rule. I've always said that this site is a liaison between medical professionals and the consumer public. That's just something I love to do. Plus a lot of them seem very timid to me. And having sort of a buffer there between them and the public puts them at ease.

One thing is for certain. They are all incredibly passionate about this topic. You can tell they get goosebumps when they start discussing it. And it's a very personal effort for them. They express the same excitement about their own research as you guys do. I haven't gotten the vibe from any of them that they are just sleazy, sweaty, greasy, snake oil salesman trying to get funding and buy their next car. Or that they know they're doing something that's complete BS, and they're just putting on a show to impress investors. I'm very sensitive to that from people, and just haven't run into it yet. Then again I've only spoken to a few of the teams so far.

Obviously there will be some exceptions to this, but I think the majority of them just stick to their petri dishes and beakers. I don't think they dig into the forums much. But who knows what Dr Tsuji does on a Saturday night at 2 AM after a few cocktails, sitting at home in front of his laptop, right?

 

[Willy31]

Please, ask if it's possible to regrowth hair on egghead (total diffuse with extreme miniaturization) :

DUPA (all the head is affected), medicinal diffuse alopecia (prozac, risperidone, etc.), Big Androgenetic Alopecia (nwd 7) and others baldness with extreme miniaturization.

Thank you !

 

[NewUser]

At a conference back in June, Walker said:

"We will be developing a topical JAK inhibitor for androgenetic alopecia, and the data on that is quite interesting in that they found that the systemic JAK inhibitor does not work for that particular indication, but the topical does, mainly as a function of the target being more superficial in the skin and not really accessible from a systemic circulation."

Be sure to ask him how exactly they know this before starting human trials. It can't be cultured hair follicles, because then the "systemic vs. topical" specification wouldn't make sense. The one thing that maybe makes sense is that they grafted some bald human Androgenetic Alopecia skin to mice and tested systemic vs. topical JAK inhibitors on them.

Yes good question. I believe Christiano et al used human skin from different donors grafted onto immune-compromised mice. I wasnt even aware of this quote from Walker/Aclaris. I did read that although the efficacy rate for JAK-inibs for a small number of test patients with AA is quite high, around 75%, they still want to know why the other 25% did not respond to JAK-inibs. Geneticist Angela Christiano and colleagues in the US and Europe said they think AA could have various subtype AA diseases and therefore may require different combos of drugs to treat that particular form of hair loss on an individual basis. They say it's not just a matter of turning off the devastating autoimmune attack on hair follicles and dermatitic skin, otherwise topical cortisone alone should work but doesn't. And they think that hair follicles devastated by autoimmune attack are still there in the skin waiting to be pushed back into anagen. Their research has important implications for other autoimmune diseases - they want to know what goes wrong when the immune system attacks healthy tissue, like it does in multiple sclerosis, diabetes and autoimmune uveitis. 5 million hair follicles there to be used as a model for study.

 

[InBeforeTheCure]

I did read that although the efficacy rate for JAK-inibs for a small number of test patients with AA is quite high, around 75%, they still want to know why the other 25% did not respond to JAK-inibs. Geneticist Angela Christiano and colleagues in the US and Europe said they think AA could have various subtype AA diseases and therefore may require different combos of drugs to treat that particular form of hair loss on an individual basis. They say it's not just a matter of turning off the devastating autoimmune attack on hair follicles and dermatitic skin, otherwise topical cortisone alone should work but doesn't. And they think that hair follicles devastated by autoimmune attack are still there in the skin waiting to be pushed back into anagen.

Do they try both tofacitinib and ruxolitinib on those 25 percent before considering them non-responders? Tofa probably wouldn't work well against type I interferon pathways since it's not that potent against JAK1, whereas ruxo might not work well against something like IL6 since it's not potent against JAK3. Maybe there are AA subtypes that would respond better to one or the other depending on which particular pathways are more active?