Gadgetine

Alfatradiol & Finasteride. Trying To Figure If Its Any Of The Same

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Towlie123

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im sorry if its a stupid question, but i cant seem to understand it abit.

i dont wanna take finasteride, dont wanna risk the sides. not by a pill and not topical.

is using Alfatradiol (topical ofcourse) is the same affect as taking finasteride, or something else entirely?
i feel kinda lost o_O

thanks for any help!
 
inmyhead

inmyhead

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Towlie123 said:
im sorry if its a stupid question, but i cant seem to understand it abit.

i dont wanna take finasteride, dont wanna risk the sides. not by a pill and not topical.

is using Alfatradiol (topical ofcourse) is the same affect as taking finasteride, or something else entirely?
i feel kinda lost o_O

thanks for any help!
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how can you think it's the same thing?

Like wtf...
 
xaragedom

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As I remember correctly in men alfatradiol at best stop hairloss while in women it can cause regrowth.
 
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Michael1986

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I think there has only been one study done on Alfatradiol, and that was on female pattern baldness and it was found to be less effective than minoxidil. There is no way that Alfatradiol comes anywhere close to the effectiveness of finasteride, and the truth is that if you want to give yourself a realistic chance of treating your hair loss successfully, you'll have to use finasteride. Without fín, you cannot win!
 
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Towlie123

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Michael1986 said:
I think there has only been one study done on Alfatradiol, and that was on female pattern baldness and it was found to be less effective than minoxidil. There is no way that Alfatradiol comes anywhere close to the effectiveness of finasteride, and the truth is that if you want to give yourself a realistic chance of treating your hair loss successfully, you'll have to use finasteride. Without fín, you cannot win!
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first of, thanks for the answer :)

may i ask why do you say theres no way is comes close to the effectivness of finasteride? what are you relying on?
thanks!
 
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supermusic

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Michael1986 said:
I think there has only been one study done on Alfatradiol, and that was on female pattern baldness and it was found to be less effective than minoxidil. There is no way that Alfatradiol comes anywhere close to the effectiveness of finasteride, and the truth is that if you want to give yourself a realistic chance of treating your hair loss successfully, you'll have to use finasteride. Without fín, you cannot win!
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I also remember a study of finasteride 1mg on females and it turned out to be very ineffective while for most men it has positive effects so that has nothing to do with it.
 
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Towlie123

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supermusic said:
I also remember a study of finasteride 1mg on females and it turned out to be very ineffective while for most men it has positive effects so that has nothing to do with it.
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isnt that abit scarry to use something that contains estradiol on men? i know high level of estradion in men can cause ED and such.
 
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Towlie123

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i mean, cant find and info except the study which was just on female.
using such things feels abit scarry for me, feel abit like a lab rat :p
 
Kaus Klinski

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Alfatradiol is biologically inactive, it doesn't act agonistically on estrogen receptors in the body, it's supposed to be a weak 5-ARI. It's pretty useless IMHO.

regards
Kaus Klinski
 
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Michael1986

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I guess I didn't give the best reference when pointing out a study on female hair loss. But there appear to be no studies at all on alfatradiol for male pattern baldness. Unlike finasteride, alfatradiol is an unproven product. Maybe it could work for you, maybe not. There's very little to go on. I personally prefer to stick with proven treatments.
 
Kaus Klinski

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BTW, Alfatradiol has never been proven to inhibit 5-ar in vivo, only in an in vitro assay of cut rat liver AFAIK. The clinical outcome when actually used on human scalp skin was quite disappointing. I used it on and off during the last 20 years, but way too short to make any valid statement. It was/is quite popular here in germany, because back then topical minoxidil was a prescription drug in germany while alfatradiol ("Ell Cranell"/"Pantostin" solution 0,025 %) was not.

BTw, why not using something "semi proven" like topical finasteride? Should at least be better than no treatment at all.

regards
Kaus Klinski
 
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Towlie123

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Kaus Klinski said:
BTW, Alfatradiol has never been proven to inhibit 5-ar in vivo, only in an in vitro assay of cut rat liver AFAIK. The clinical outcome when actually used on human scalp skin was quite disappointing. I used it on and off during the last 20 years, but way too short to make any valid statement. It was/is quite popular here in germany, because back then topical minoxidil was a prescription drug in germany while alfatradiol ("Ell Cranell"/"Pantostin" solution 0,025 %) was not.

BTw, why not using something "semi proven" like topical finasteride? Should at least be better than no treatment at all.

regards
Kaus Klinski
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hey, and thanks for the long answer!

personally, i dont wanna touch finateride, sides scares me too much, and i dont wanna take the risk.

i went to a "hair clinic", they told me my state is in a really really early stages, and no need to "big cannons", just to stop it. not sure what that means.
anyways, they said, you can use our foam, which needs a prescripstion from a doctor, and containts minoxidil and alfatradiol.
what im trying to figure out here, is i have any logic reason to use this, than just using minoxidil.

im scared of using something that is backed up by any research, and i feel like its not a smart move. but then again, your saying "maybe they know something"?
im scared of the chances of side from alfatradiol, since theres 0 info about it, and also feeling like it might be something that results wise, is worthless (and then i might be losing, since ill be using their minoxidil instead of a better known company minoxidil)

decision in this "hair area" are damn hard
 
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Towlie123

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Kaus Klinski said:
Alfatradiol is biologically inactive, it doesn't act agonistically on estrogen receptors in the body, it's supposed to be a weak 5-ARI. It's pretty useless IMHO.

regards
Kaus Klinski
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where are you taking this info from?
thats what i was missing from the clinic when they told me to use it, and actuall explanation on why it shouldnt have sides.
or maybe thats not enough and theres still a risk? :p
 
Kaus Klinski

Kaus Klinski

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Towlie123 said:
where are you taking this info from?
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There is plenty of information out there concerning the biological inactivity of the "a"-isomer of estradiole, but mostly on german sites. Here is what wikipedia (english) has about it:

https://en.wikipedia.org/wiki/Alfatradiol

Trust me, it has negligible estrogenic effects (if at all), otherwise it would be prescription only, german laws are very strict.

Bottom line: it will probably not harm you and *could* have some positive effect on hair loss, but it is probably not much better than minoxidl alone. It's your decision. If I could afford it and wouldn't want to use finasteride, I would use it.

regards
Kaus Klinski

Btw: where are you from?
 
Kaus Klinski

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Towlie123

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Kaus Klinski said:
There is plenty of information out there concerning the biological inactivity of the "a"-isomer of estradiole, but mostly on german sites. Here is what wikipedia (english) has about it:

https://en.wikipedia.org/wiki/Alfatradiol

Trust me, it has negligible estrogenic effects (if at all), otherwise it would be prescription only, german laws are very strict.

Bottom line: it will probably not harm you and *could* have some positive effect on hair loss, but it is probably not much better than minoxidl alone. It's your decision. If I could afford it and wouldn't want to use finasteride, I would use it.

regards
Kaus Klinski

Btw: where are you from?
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im from israel, here it requires a prescription. because i dont see any studies about it (except the one on korean women), and it requires a prescription (will be made just for me in a pharmacy), it makes me abit scared. (plus, they told me it should be used once a day, instead of twice like normal minoxi, which is also abit weird)

i mean, if it was a viable "tool", wouldnt it be sold like minoxi and such? there's barely any info about it.
and i mean, for it to be better than minoxi, should it affect DHT levels? (and if it does - sides are an option, no?)

i really appreciate all the help btw.

i mean, how can i actually know its safe?
and why do you say that? "but it is probably not much better than minoxidl alone" :))


p.s
finasteride: "Finasteride is a 5α-reductase inhibitor.["
alfatradiol: "Alfatradiol acts as an inhibitor of the enzyme 5α-reductase"

so, isnt it just like a "weak" finasteride? might help much less, but also might cause much less sides?
or is there another affect in Alfatradiol that helps the hair (other than reducing DHT)?
 
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Kaus Klinski

Kaus Klinski

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*If* it affects DHT levels, then only in the scalp, because the a-isomer of estradiol has a very low systemic absorption/effect. But as I said before, it is unproven to do so "in vivo" and the very limited number of studies and empirical experience we have with the agent doesn't seem to show any considerable effect on male pattern baldness when used on actual balding scalps. That's why I said it's probably not better than minoxidil alone.

Again: if you can afford it, use it, just to take the chance that it *might* work to some degree. Any side effects except for local skin irritatiion due to the alcohol/solvent content of the solution are not to be expected. So, if it doesn't help, at least it probably won't hurt.

regards
Kaus Klinski
 
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