Allergan acquires Kythera and Setipriprant

[shivers20]

http://kythera.com/allergan-to-acquire-kythera-biopharmaceuticals/

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The acquisition will also add KYTHERA’s development product setipiprant (KYTH-105), a novel compound for the prevention of male pattern baldness, as well as additional early-stage development candidates.

 

[Ziggyz123]

Hopefully, with allergan mainly wanting control of the double chin injectable, setipiprant doesn't get put on the back burner....

 

[hellouser]

Hopefully, with allergan mainly wanting control of the double chin injectable, setipiprant doesn't get put on the back burner....

It might. NEOSH-101 got that treatment when it was acquired by another biotech/pharmaceutical.

 

[resu]

Maybe they'll make a pack with the two drugs for just $100 a month, bim and seti won't be cheap they know they'll exploit us till we have nothing.

 

[hellouser]

Maybe they'll make a pack with the two drugs for just $100 a month, bim and seti won't be cheap they know they'll exploit us till we have nothing.

They'll exploit anyone, not just balding men. These people are in the business of raping peoples wallets before actually helping them. They're not humanitarians.

 

[Ziggyz123]

They'll exploit anyone, not just balding men. These people are in the business of raping peoples wallets before actually helping them. They're not humanitarians.

Haha, "they're not humanitarians".
Well said. Someone on BTT quoted something very interesting though. This particular statement was actually made in 2014 before we even knew what molecule kythera was about to release to us.

Here is an interesting quote: "Combination Therapy: The true Holy Grail may come from combining a drug like Latisse with a certain type of medication commonly used to treat allergies and asthma. The medication blocks a hormone-like substance that prevents hair from growing. A treatment like this might help with hair growth. 'Using these drugs in combination is like taking your foot off-break and stepping on gas at the same time,' Washenik says. "

http://www.webmd.com/skin-problems-...s/news/20140331/hair-loss-treatments-pipeline

 

[resu]

I hope it gives the same cosmetic results as a standard FUE or better, that would be a real treatment.

 

[abcdefg]

A combo like that could turn out to be a game changer or another dud. Lets hope it turns out amazing. At the very least hopefully a solid safe way to keep all your hair for many decades.

 

[it2wi]

"Brent Saunders, CEO and president of Allergan, explained the purpose of the acquisition: Kybella will do that while complementing our market leading facial aesthetics portfolio, which includes Botox, Juvederm XC, Juvederm Voluma XC, Latisse and Skinmedica. Kybella is also a pivotal entry point for expanding the use of facial aesthetic products in men, while Kythera’s setipiprant (hair-loss) development program can drive additional long-term value."

The way I read this (as this is a message to investors, not the hair-loss community) is "setipiprant will be a source of continued cashflows over time".. i.e. customers who use it will have to continue to buy it (like how we do with finasteride).

I really think that last sentence indicates that Allergen has plans for developing setipiprant into being a staple part of its product offerings. What company wouldn't want a boost in revenue, one that is reliably consistent and continues on for the foreseeable future?

 

[Ziggyz123]

A combo like that could turn out to be a game changer or another dud. Lets hope it turns out amazing. At the very least hopefully a solid safe way to keep all your hair for many decades.

Well, we have the combo of minoxidil and propecia and people still can't hold on to their hair.. Seti is a hunch still that "may" work to halt hairloss.. At least finasteride lets some regrow. I didn't respond at all to finasteride and actually worsened due to some type of inflammation after 1 year of use along my hairline.. Hopefully seti tackles that issue because finasteride destroyed me hair/hairline.

 

[abcdefg]

Well, we have the combo of minoxidil and propecia and people still can't hold on to their hair.. Seti is a hunch still that "may" work to halt hairloss.. At least finasteride lets some regrow. I didn't respond at all to finasteride and actually worsened due to some type of inflammation after 1 year of use along my hairline.. Hopefully seti tackles that issue because finasteride destroyed me hair/hairline.

minoxidil and finasteride are first generation treatments. The stuff coming is second gen and I have a hard time believing they wont work a lot better than what exists now. There are numerous things even if something like seti turns out to not work. Seti is unknown but it could work better than predicted or not at all. It has good evidence though it will do something maybe its more effective at just keeping hair then finasteride with less sides.

 

[Swoop]

I think both bima & setip will bring nothing better than the meds we already have. Although I hope I'm wrong.

 

[kirk]

I think both bima & setip will bring nothing better than the meds we already have. Although I hope I'm wrong.

I think...

1) New treatments will at least be as effective with less/no chance of sides.
2) Perform better

Otherwise why bother?

 

[Kenny's_Login]

I think both bima & setip will bring nothing better than the meds we already have. Although I hope I'm wrong.

Neither drug would proceed to human testing if there were no profit incentive, and the profit incentive only exists because the drugs are indeed effective.

Human testing is expensive. Very expensive. There is a spinoff industry built around it that is very profitable. Human test subjects get paid thousands for one or two weeks of staying within a controlled environment.

And when I say controlled, I mean it's like a prison hospital. You're not allowed to leave, you sleep in a room full of bunk beds, your meals are scheduled and regimented on calories, you have between three and 20 blood draws per day, your urine is collected, you walk around with EEG nodes taped to your body, you cannot do much physical activity, your financial stipend loses money every time you are late, and people are kicked out regularly for breaking rules.

The cost of all this control, plus the nurses and techs tending to you, is huge. A drug maker isn't going to proceed to phase III if the product is not superior to what is already on the market.

 

[Swoop]

The cost of all this control, plus the nurses and techs tending to you, is huge. A drug maker isn't going to proceed to phase III if the product is not superior to what is already on the market.

Where do you see any mention of a phase 3 in relation to either bima or seti?

 

[Ziggyz123]

Where do you see any mention of a phase 3 in relation to either bima or seti?

Yeah, I'm with Swoop. i know seti will be starting in phase 2, but it hasn't even entered yet.

 

[Kenny's_Login]

Said phase III, meant phase II, but it doesn't matter either way. The controlled environment and its expenses apply to phase I, II, and sometimes III.

 

[Swoop]

Said phase III, meant phase II, but it doesn't matter either way. The controlled environment and its expenses apply to phase I, II, and sometimes III.

Flawed logic dude. Many drugs don't get past phase 2 clinical trials. In fact phase 2 success rate is only 18% and phase 3 is about 50% success rate. Even in phase 3 the failure reason is often lack of efficacy.

http://www.highlighthealth.com/rese...ew-drugs-are-failing-phase-ii-and-iii-trials/

A recent analysis by the Centre for Medicines Research in the UK has concluded that since 2008, the failure rate for drugs in Phase II and III clinical trials has been rising [1-2]. Phase II success rates are currently at 18%, lower than at any other phase of drug development.

Phase II success rates are currently at 18%, lower than at any other phase of drug development.

At Phase III, the failure rate is now at about fifty percent

 

[shivers20]

The pieces are all falling into place with Cots patents and the Allergan acquisition of Kythera.. Seti will replace Finasteride. Bim is slightly more complicated. Based on the email response a member on here received sounds like it works but there are issues- only works in some patients, possible side effects, expensive compared to minoxidil, must be applied 3+ times daily, all speculation of course.

 

[jasonbourne]

The pieces are all falling into place with Cots patents and the Allergan acquisition of Kythera.. Seti will replace Finasteride. Bim is slightly more complicated. Based on the email response a member on here received sounds like it works but there are issues- only works in some patients, possible side effects, expensive compared to minoxidil, must be applied 3+ times daily, all speculation of course.

Will seti preserve hair longer than finasteride?

Let's say finasteride works for 10 years for person x. Would seti work for 30 years for that person?


Re growth possibilities??