Please comment.
Comebackkid's response to me on regrowth.com
Basically, I think when you're taking a 5ar blocker like Finasteride or Dutasteride you're reasonably well sorted against DHT activating the androgen receptor - and DHT is the most potent at doing so - but there are still other androgens that activate the AR like Testosterone and Androstenedione (which are the androgens I believe that lead to a more diffuse thinning pattern). So, your options to counteract the effects of these remaining androgens mostly lie with substances that block the AR completely. In my research these would include; topical Spironolactone, topical Flutamide, RU, Fluridil and perhaps Revivogen (as I think it's been loosely demonstrated this is effective at blocking the effects of Testosterone in the scalp - or something like that!).
Those who have the greatest success with Propecia are, I think, those who are less sensitive to androgens in general. If you're unlucky enough to be very sensitive to androgens then although Propecia may slow down your loss, I don't think you'd really have much chance of halting hair loss progression when your androgen receptors are continuing to be activated by other androgens. This is happening with the guys that are less sensitive to androgens too, but without as great an impact.
I'm not saying that this is the best way to do it, it's just my opinion. I think people need to do their own research and talk to others on hair loss forums as, invariably, what works for someone doesn't work for someone else! Hope that sort of helps.
Comebackkid's response to me on regrowth.com
Basically, I think when you're taking a 5ar blocker like Finasteride or Dutasteride you're reasonably well sorted against DHT activating the androgen receptor - and DHT is the most potent at doing so - but there are still other androgens that activate the AR like Testosterone and Androstenedione (which are the androgens I believe that lead to a more diffuse thinning pattern). So, your options to counteract the effects of these remaining androgens mostly lie with substances that block the AR completely. In my research these would include; topical Spironolactone, topical Flutamide, RU, Fluridil and perhaps Revivogen (as I think it's been loosely demonstrated this is effective at blocking the effects of Testosterone in the scalp - or something like that!).
Those who have the greatest success with Propecia are, I think, those who are less sensitive to androgens in general. If you're unlucky enough to be very sensitive to androgens then although Propecia may slow down your loss, I don't think you'd really have much chance of halting hair loss progression when your androgen receptors are continuing to be activated by other androgens. This is happening with the guys that are less sensitive to androgens too, but without as great an impact.
I'm not saying that this is the best way to do it, it's just my opinion. I think people need to do their own research and talk to others on hair loss forums as, invariably, what works for someone doesn't work for someone else! Hope that sort of helps.