Androgen Modulation Of Wnt/β-catenin Signaling In Androgenetic Alopecia

[NotInmywatch]

A recent article that offers new light on this pathway.
http://docdro.id/PM2eVQH

"
In the case of Androgenetic Alopecia, the Hair Follicles have a diminished anagen phase due to unstable β-catenin. Stabilizing β-catenin through amplifying Wnt signals would extend the anagen phase and delay the onset of catagen phase in Hair Follicles.

Modulating the Androgen Receptor transactivation and stabilizing Wnt/β-catenin signaling pathway would cure, reverse, and prevent hair loss in Androgenetic Alopecia with minimized side effcts. Besides new treatments, targeting Wnt pathway has shown a promising effct on hair growth.

Interestingly, natural products from herbs such as Aconiti Ciliare, Malva verticillata, Thuja orientalis, and Acanthopanax koreanum are shown to treat hair loss by promoting Wnt/β-catenin activity [21, 60].

R-spondin 2 injection repressed catagen onset and extended the anagen phase resulting in longer hair shaft growth.

Valproic acid (VPA), a GSK-3β inhibitor, that activates Wnt/β-catenin activity induced hair regeneration in murine
models

"

 

[BaldAsshole]

Effect of curcumin on the interaction between androgen receptor and Wnt/β-catenin in LNCaP xenografts

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565901/

 

[NotInmywatch]

this pathway has a very important role in cancer. it's very frightening just toying around with it.
I hope those SAMUMED guys with sm04554 really make sure that it cures hair loss without the side effect of getting carcinoma/melanoma.

 

[Trichosan]

"Effect of curcumin on the interaction between androgen receptor and Wnt/β-catenin"
Interesting. Been taking curcumin orally for years. Unfortunately, not before hair reached present undesirable state.

"Interestingly, natural products from herbs such as Aconiti Ciliare, Malva verticillata, Thuja orientalis, and Acanthopanax koreanum are shown to treat hair loss by promoting Wnt/β-catenin activity"
Guess I'll add some more. I'm already a walking herb garden for all kinds of other crap. Maybe it's an addiction.

 

[champpy]

"Effect of curcumin on the interaction between androgen receptor and Wnt/β-catenin"
Interesting. Been taking curcumin orally for years. Unfortunately, not before hair reached present undesirable state.

"Interestingly, natural products from herbs such as Aconiti Ciliare, Malva verticillata, Thuja orientalis, and Acanthopanax koreanum are shown to treat hair loss by promoting Wnt/β-catenin activity"
Guess I'll add some more. I'm already a walking herb garden for all kinds of other crap. Maybe it's an addiction.

Are you still losing or has the loss stopped at all?

 

[Trichosan]

Are you still losing or has the loss stopped at all?

I think the loss has maxed out now at my age. It was a slow creep of the hairline receding through late 20's-30's, thinning of crown becoming noticeable 40's-50s. Typical N5V now. But can any
male be sure where it will stop? Or we just don't live long enough to see the total marblehead of dht destruction?

 

[Jk1]

repeated dermarolling increase wnt beta cateni pathway

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064188/

i have been doing lightly 1.5mm daily dermarolling for last 3 weeks with what seems only positive gains in growth !

so if i had done this before any loss it would have stopped male pattern baldness ?

 

[furrydome]

repeated dermarolling increase wnt beta cateni pathway
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064188/
i have been doing lightly 1.5mm daily dermarolling for last 3 weeks with what seems only positive gains in growth !
so if i had done this before any loss it would have stopped male pattern baldness ?

The real question here: Does wounding reduce androgen sensitivity?

Some anecdotal evidence suggests that it does: campfire man, @Somebody

 

[NotInmywatch]

repeated dermarolling increase wnt beta cateni pathway

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064188/

i have been doing lightly 1.5mm daily dermarolling for last 3 weeks with what seems only positive gains in growth !

so if i had done this before any loss it would have stopped male pattern baldness ?

hi Jk1, sorry, how do you define "lightly"? 1.5mm daily sounds brutal. Most regimens recommend 1.5mm every 1 or 2 weeks. Would that be only 1 pass instead of several?

 

[Jk1]

lightly as maybe only 0.5mm goes in no blood slight redness... i do it in the morning before going to work . and dont even wash off or do anything else lol as it takes 2 min.

i still need to do the weekly deep 1.5mm wounding on top of the daily..