squeegee
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More evidence of an ovary-neuron axis that is disturbed in PCOS.
Exp Neurol. 2011 Jan 15
Sex differences in the manifestation of peripheral diabetic neuropathy
in gonadectomized rats: A correlation with the levels of neuroactive
steroids in the sciatic nerve.
Pesaresi M, Giatti S, Cavaletti G, Abbiati F, Calabrese D, Bianchi R,
Caruso D, Garcia-Segura LM, Melcangi RC.
Dept. of Endocrinology, Pathophysiology and Applied Biology, Center of
Excellence on Neurodegenerative Diseases, Universita degli Studi di
Milano, Milano, Italy.
Clinical observations suggest a sex-dimorphism in the incidence and
symptomatology of diabetic neuropathy, but this possible gender effect
has never been investigated in detail in a well-characterized
experimental model such as streptozotocin (STZ)-induced diabetes.
Therefore, in this study we have compared with a multimodal set of tests
the impact of diabetes on the sciatic nerve in male and female rats. To
assess whether sex-dimorphism in peripheral diabetic neuropathy is
dependent on gonadal hormones we have also analyzed the effect of
ovariectomy and orchidectomy on the sciatic nerve of STZ-diabetic rats.
Nerve conduction velocity (NCV), Na(+),K(+)-ATPase activity, expression
of myelin proteins, thermal sensitivity and reactive oxygen species
production were similarly affected in male and female animals by STZ.
However, ovariectomy, but not orchidectomy, significantly counteracted
STZ-induced alterations on NCV, Na(+),K(+)-ATPase activity, and
expression of myelin proteins. This effect of ovariactomy was associated
to an increase in the levels of neuroactive steroids, such as
dehydroepiandrosterone, testosterone and dihydrotestosterone, in the
sciatic nerve of diabetic rats. These neuroactive steroids have been
demonstrated to be protective agents in this experimental model of
diabetic neuropathy. However, their efficacy has been so far tested only
in male animals. Therefore, the present data might represent an
important background to evaluate their efficacy also in female diabetic
animals. Copyright (c) 2011. Published by Elsevier Inc.
Exp Neurol. 2011 Jan 15
Sex differences in the manifestation of peripheral diabetic neuropathy
in gonadectomized rats: A correlation with the levels of neuroactive
steroids in the sciatic nerve.
Pesaresi M, Giatti S, Cavaletti G, Abbiati F, Calabrese D, Bianchi R,
Caruso D, Garcia-Segura LM, Melcangi RC.
Dept. of Endocrinology, Pathophysiology and Applied Biology, Center of
Excellence on Neurodegenerative Diseases, Universita degli Studi di
Milano, Milano, Italy.
Clinical observations suggest a sex-dimorphism in the incidence and
symptomatology of diabetic neuropathy, but this possible gender effect
has never been investigated in detail in a well-characterized
experimental model such as streptozotocin (STZ)-induced diabetes.
Therefore, in this study we have compared with a multimodal set of tests
the impact of diabetes on the sciatic nerve in male and female rats. To
assess whether sex-dimorphism in peripheral diabetic neuropathy is
dependent on gonadal hormones we have also analyzed the effect of
ovariectomy and orchidectomy on the sciatic nerve of STZ-diabetic rats.
Nerve conduction velocity (NCV), Na(+),K(+)-ATPase activity, expression
of myelin proteins, thermal sensitivity and reactive oxygen species
production were similarly affected in male and female animals by STZ.
However, ovariectomy, but not orchidectomy, significantly counteracted
STZ-induced alterations on NCV, Na(+),K(+)-ATPase activity, and
expression of myelin proteins. This effect of ovariactomy was associated
to an increase in the levels of neuroactive steroids, such as
dehydroepiandrosterone, testosterone and dihydrotestosterone, in the
sciatic nerve of diabetic rats. These neuroactive steroids have been
demonstrated to be protective agents in this experimental model of
diabetic neuropathy. However, their efficacy has been so far tested only
in male animals. Therefore, the present data might represent an
important background to evaluate their efficacy also in female diabetic
animals. Copyright (c) 2011. Published by Elsevier Inc.