Anti-DHT effects of lauric, oleic and alpha-linoleic acids

[vauxall]

They didn't specify it it was for topical or nutritional use, but considering that these oils are very cheap.......

http://www.ncbi.nlm.nih.gov/pubmed/19353546

Anti-androgenic activity of fatty acids.Liu J, Shimizu K, Kondo R.
Department of Forest and Forest Products Science, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan.

In this study, we show that 5alpha-reductase derived from rat fresh liver was inhibited by certain aliphatic free fatty acids. The influences of chain length, unsaturation, oxidation, and esterification on the potency to inhibit 5alpha-reductase activity were studied. Among the fatty acids we tested, inhibitory saturated fatty acids had C12-C16 chains, and the presence of a C==C bond enhanced the inhibitory activity. Esterification and hydroxy compounds were totally inactive. Finally, we tested the prostate cancer cell proliferation effect of free fatty acids. In keeping with the results of the 5alpha-reductase assay, saturated fatty acids with a C12 chain (lauric acid) and unsaturated fatty acids (oleic acid and alpha-linolenic acid) showed a proliferation inhibitory effect on lymph-node carcinoma of the prostate (LNCaP) cells. At the same time, the testosterone-induced prostate-specific antigen (PSA) mRNA expression was down-regulated. These results suggested that fatty acids with 5alpha-reductase inhibitory activity block the conversion of testosterone to 5alpha-dihydrotestosterone (DHT) and then inhibit the proliferation of prostate cancer cells.
PMID: 19353546 [PubMed - indexed for MEDLINE]

 

[Bryan]

They didn't specify it it was for topical or nutritional use...

It was an in vitro study. The fatty acids were applied to prostate tissue in a test-tube.

but considering that these oils are very cheap....

They didn't apply OILS, they applied FATTY ACIDS. And free-form fatty acids definitely aren't cheap! :shock:

If you're interested in the idea of applying fatty acids to your scalp to fight male pattern baldness without any systemic side effects, you can always use Revivogen.

 

[vauxall]

Thank you for the clarification Bryan and can I just remind you that oils are indeed fatty acids. They call them oils because they are in a viscous liquid state ("oily") at ambient temperatures.

 

[armandein]

Exist lipases in skin and/or pilosebaceous unit?

Armando

 

[Bryan]

Thank you for the clarification Bryan and can I just remind you that oils are indeed fatty acids. They call them oils because they are in a viscous liquid state ("oily") at ambient temperatures.

Fatty acids are constituents of oils. Even though they may have similar outward appearances, I don't think you'd ever hear a medical professional or a chemist refer to a bottle of linoleic acid as a bottle of "oil". Certainly not in a professional publication like a medical or science journal!

 

[Bryan]

Exist lipases in skin and/or pilosebaceous unit?

Probably. At least to some degree.

 

[armandein]

Exist lipases in skin and/or pilosebaceous unit?

Probably. At least to some degree.

And then, what is the problem with natural oils?
BTW acids are acids, in sometimes is better to use trigligreides to avoid irritations....

Armando

 

[rcom440]

fatty acids are nothing but carboxylic acid ( -COOH or -CO2H )

 

[Bryan]

Exist lipases in skin and/or pilosebaceous unit?

Probably. At least to some degree.

And then, what is the problem with natural oils?

An actual experiment with putting natural oil on the skin of a human test-subject found that it had little apparent effect at reducing DHT. There are probably _some_ lipases in the skin, but they're evidently not terribly effective.

 

[47thin]

AT the end of the day, doesn't shampooing hair remove "some" DHT? In other words, it isn't if it removes some DHT, but how much DHT on the scalp?

 

[armandein]

quote]

An actual experiment with putting natural oil on the skin of a human test-subject found that it had little apparent effect at reducing DHT. There are probably _some_ lipases in the skin, but they're evidently not terribly effective.[/quote]

Hi Bryan;
can you be more specific about the actual experiment?
TIA
Armando