Any News On Samumed / Sm04554? (video)
- Thread starter Mr White
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It's not dead, and you can even buy it now as a research chemical. Guys on YouTube just want clicks and ad revenue. Don't get hyped up over it. It has merit, but it is less effective than finasteride. Should have some benefit in conjuction with it. It's a wnt disinhibitor. I don't know if it works by inhibiting SFRP, DKK or some other means, but there are other drugs out there that do these things. sm isn't revolutionary
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It's not less effective. It's different. It's not acting on AR, but on WNT. an It triggers regrowth if dosage is right. The last part being the most difficult to get because the best results came out with the lesser dosage.
It doesn't act on Wts. We don't know what it acts on except that we know it acts on something that inhibits Wnts. It is a completely different pathway from finasteride, which is why I said it should have synergistic effects with finasteride. By itself it is less effective than finasteride by itself. We know this because we have clinical trials for both, and there was only marginal improvement with SM alone. Getting the dosing right isn't a problem because we have the clinical trials. IIRC .15% was the most effective dose. Wnt disinhibitors could become a staple in treating hariloss, but they will never be an alternative to AAs or 5-AR inhibitors.
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I think it was 0.15% not 15%. Can It have a synergetic effect with Duta as well?
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The only issue I have with that powder is that is red as blood. Makes your scalp look like an horror movie and hands/nails take a long time to clean up.
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I've been combining both for 2 weeks. I am annoyed by the red tint of the solution. It requires extra planning when applying and socialising.
Can you apply it before bed? Does the tint wash off in the shower? WAY is white, so when you get that you can just use that when you're going to be going out. SAG is also a potent Wnt disinhibitor. It inhibits SFRP1 by about 70% and also SFRP2. So it does the same job as both of these in addition to activating Wnt signalling.
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My SAG is on order. I'll try it. My current potion is WAY+SEQUOL+SM+TM at various doses. I apply Valproic acid too.
I wanted to jump the peptide (ptd-dbm) bandwagon, but the current experiments seem to grow non-pigmented hair only on humans.
I wanted to jump the peptide (ptd-dbm) bandwagon, but the current experiments seem to grow non-pigmented hair only on humans.
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I think I do as I added Sulfasalazine recently.
SM04554 is less effective than finasteride .... ¿? I hope you are wrong .... SM is the first medicine that is in phase 3 , if it doesnt best than finasteride and minoxidil and bring something new in the Androgenetic Alopecia problem ,Samumed won't put it on the market
From my experience Finasteride itsnt a cure , and in many cases does nothing by itself = 0 improvement in many people.... The AAs or 5-AR inhibitors by itself arent a panacea
The problem is that Finasteride doesn't stop hairloss in many cases.Never mind if you have a full head of hair.
There are a lot of people aged 18,19,20 ... and norwoods 1,2 who start taking finasteride.In two or three years they are norwoods 3-5
Attack via AAR 5ARS by itself doesnt work. We have known this for many years
We need better drugs than Finasteride and Minoxidil.Also both have side effects
Per the the second trial Sm did create some new follicles.Trial people "only" are using SM
I hope via WNT bring something new and positive
SM does not cause HFN, and it will not stop hair loss in anyone who doesn't respond to finasteride. If your case is so aggressive that finasteride doesn't help then SM can't stop it either. Sorry, but there are no drugs in the pipeline that are better than finasteride/dutasteride and minoxidil, only drugs that will work synergistically with them to improve on them. If you have so much faith in SM go ahead and get it now. There are dozens of places making it.
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Do you believe combining SM with AA's is usefull?
AA's have always produced better results on me then 5-ARI inhibitors.
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So its a 5% improvement? Am i reading this correctly?
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pegasus your regime has a lot. I’m interested in adding more. I take finasteride/minoxidil and alfadrol
Do you mix most of those or use them separate.
what is your favorite places to get your regimen ?
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Since the rule of this form is not to publish sources it's better to pm and ask.
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In what area? Breasts or hair? I think it's important to consider sides with AA more than 5-ARI. Topical AA will go systemic. You need s major commitment when using AA at dosage that's meaningful to hair growth.