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Digidako

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If we just sit here and wait for these pharmaceutical companies to make announcements about whatever they're working on, we will all be NW7.
We need to take matters into our own hands if we want to expect any changes
 

distracted

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Idk but I've been seeing more and more people doubting Replicel. It's frustrating since I kept telling myself that I just need to maintain or stick out till ~2018, but if Replicel is a bust than there is nothing I would be even looking forward to.
 

bbbeeeppp2

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Idk but I've been seeing more and more people doubting Replicel. It's frustrating since I kept telling myself that I just need to maintain or stick out till ~2018, but if Replicel is a bust than there is nothing I would be even looking forward to.

Yeah. I'm depressed as hell about our possible future treatments now. Back in the summer I was hopeful about Replicel, Histogen, Seti and Swiss's PG protocol. Now it seems they're either not going to do **** or likely going to be no where near what we were hoping.

I know people joke about how the cure is always 5-10 years away, but it's frustratingly accurate. The only half effective treatment we have are anti-androgens which we've had for 25 years now. We have made next to no progress since the 90s.
 

Digidako

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Yeah. I'm depressed as hell about our possible future treatments now. Back in the summer I was hopeful about Replicel, Histogen, Seti and Swiss's PG protocol. Now it seems they're either not going to do **** or likely going to be no where near what we were hoping.

I know people joke about how the cure is always 5-10 years away, but it's frustratingly accurate. The only half effective treatment we have are anti-androgens which we've had for 25 years now. We have made next to no progress since the 90s.
That's because androgens are only half of the problem
Refer to my post here: http://www.hairlosstalk.com/interac...or-in-Androgenetic Alopecia-Mechanical-Stress
 

Pavi

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I still think our most immediate hope is Samumed. They already announced it increased hair count and hair density, and their participants (or most of) had higher norwoods. Yes, they delayed the conclusion of their phase IIb, but that isn't necessarily a bad thing (if it was terrible, why not just stop?).

Nobody seems to care about a European company called polichem. They're in phase III for a topical finasteride
 

wilson2

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Nobody seems to care about a European company called polichem. They're in phase III for a topical finasteride

I think a lot of guys on here are already on finasteride. So the idea of topical finasteride (which would probably be less effective than regular finasteride) is not a huge deal to them. However I am definitely keeping an eye on polichem. If it can be 1/4 as effective as finasteride without the side effect profile I would be excited.
 

tangled

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30 years ago we told ourselves the same thing "baldness will be cured in 5 years".

As we cut our proscar in quarters until propecia came out.

30 years later, not much has changed.

unfortunately.
 

Felipe302

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Nobody seems to care about a European company called polichem. They're in phase III for a topical finasteride


Honestly, after reading some guys reporting side effects on CB 03 01, im skeptical that antiandrogenics will ever be side effects free.
 

Swoop

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30 years ago we told ourselves the same thing "baldness will be cured in 5 years".

As we cut our proscar in quarters until propecia came out.

30 years later, not much has changed.

unfortunately.

0xAW6Ig.gif
 

Follisket

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Yeah, it's terrifying and I'm surprised we're just taking it up our poopholes quiety. Pretty much everything turned out to be a bust. What's there even left?

Just months ago, with all the exciting treatments in the pipeline, it felt like there was absolutely no way that a few years from now, we wouldn't have a reliable means of either regrowing or otherwise safely obtaining a full head of hair - at least for <NW4. Failure seemed practically impossible. Now suddenly, we're flooded with disappointments.

People getting no real results on seti or, at best, ones comparable to OC (decreased itch, etc.).
Bimatoprost might give only slightly better results than minoxidil if/once it comes out, which isn't really saving anyone.
Piloscopy has clearly wound down all talk of significant donor regeneration, so it's safe to assume it won't come anywhere close to providing us with a life-long supply of donor hair. Absent that, hair transplants remain a risky fix.
Histogen showed minimal regrowth with some shady photos and combovers calling everything into question.
Replicel, meanwhile, is trying to steer clear of any mention of regrowth alltogether.
While we weren't sure Replicel would offer any regrowth to begin with, there was talk of Shiseido supposedly having found a cure of sorts and for quite some time we assumed that what they had was an upgraded version of Replicel's treatment. Now that we've received confirmation it's basically the same thing, we're screwed. Maintenance only; years from now, Norwoods from now.

Not to mention the ton of other mediocre further delayed growth stimulants which will be out in like 6 years' time. Please, look forward to shelling out thousands of dollars to maintain wispy little tufts of hair. Bet that'll get us some mad tail, brah.

And not one of these companies dares to really talk about any significant Norwood-spanning regrowth. Not even talking full NW7 reversal here; none of them ever even remotely hinted at being able to regrow and fill in 2 miserable low NWs - not even with repeat treatments and/or stronger doses! Given that they are probably striving for as much good publicity as possible and generally likely to overpromise, that is telling.

And goddamn it, dat fine Ackles hairline...
 

wilson2

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hmm. It may be time to invest our money and research into robotic sex slaves. brb registering roboticsexslavetalk. com
 

abcdefg

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Honestly, after reading some guys reporting side effects on CB 03 01, im skeptical that antiandrogenics will ever be side effects free.

Relying on people to accurately report sides is like going to casino with intent of walking out a millionaire. Silly. Everything that happens they will attribute to that whether its related or not. Without a study adjusting for control group its meaningless.
 

Swoop

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Yeah, it's terrifying and I'm surprised we're just taking it up our poopholes quiety. Pretty much everything turned out to be a bust. What's there even left?

Just months ago, with all the exciting treatments in the pipeline, it felt like there was absolutely no way that a few years from now, we wouldn't have a reliable means of either regrowing or otherwise safely obtaining a full head of hair - at least for <NW4. Failure seemed practically impossible. Now suddenly, we're flooded with disappointments.

People getting no real results on seti or, at best, ones comparable to OC (decreased itch, etc.).
Bimatoprost might give only slightly better results than minoxidil if/once it comes out, which isn't really saving anyone.
Piloscopy has clearly wound down all talk of significant donor regeneration, so it's safe to assume it won't come anywhere close to providing us with a life-long supply of donor hair. Absent that, hair transplants remain a risky fix.
Histogen showed minimal regrowth with some shady photos and combovers calling everything into question.
Replicel, meanwhile, is trying to steer clear of any mention of regrowth alltogether.
While we weren't sure Replicel would offer any regrowth to begin with, there was talk of Shiseido supposedly having found a cure of sorts and for quite a while we assumed that what they had was an upgraded version of Replicel's treatment. Now that we've received confirmation it's basically the same thing, we're screwed. Maintenance only; years from now, Norwoods from now.

Not to mention the ton of other mediocre further delayed growth stimulants which will be out in like 6 years' time. Please, look forward to shelling out thousands of dollars to maintain wispy little tufts of hair. Bet that'll get us some mad tail, brah.

And not one of these companies dares to really talk about any significant Norwood-spanning regrowth. Not even talking full NW7 reversal here; none of them ever even remotely hinted at being able to regrow and fill in 2 miserable low NWs - not even with repeat treatments and/or stronger doses! Given that they are probably striving for as much good publicity as possible and generally likely to overpromise, that is telling.

And goddamn it, dat fine Ackles hairline...

Well said Follisket, but quite frankly almost everything was extremely predictable. Especially if you are somewhat aware of hair follicle biology and just look at it from an objective standpoint.

Seti, bima, histogen. I was 100% pretty sure of them being bunk sh*t. In the sense that they wouldn't be better than minoxidil and finasteride.

On SM I had question marks because I couldn't relate the compound to any observational evidence in vivo. But it's already to quiet around them. I assume now it isn't going to outperform minoxidil.

Do you know what companies like to do the most in this sector? They absolutely love to release good results and flaunt with them. If they don't have good results or mediocre results they tend to hold back.

Look at this; https://www.zacksinvest.com/histogen-inc

Seems Histogen looks for funding am I correct? LMAO. ANY treatment that would reverse even a norwood or 2 or be better than minoxidil is worth more than 18 million EASILY.

But wait;

I brought up the crowdfunding idea particularly with regards to Follica and he said the amount necessary is quite large. So I insisted on an actual amount and here's what he said: "US $2 million would bring out a product that would be more effective than Minoxidil and Propecia but would not give a bald person a full head of hair. US $20 million will provide the kind of funding necessary to give someone who is already bald a full head of hair but it will take more years to accomplish".

Maybe we should get Dr. Cotsarelis 2 million. Because you know that would bring out a product that is more effective than minoxidil;

giphy.gif
 

distracted

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Well said Follisket, but quite frankly almost everything was extremely predictable. Especially if you are somewhat aware of hair follicle biology and just look at it from an objective standpoint.

Seti, bima, histogen. I was 100% pretty sure of them being bunk sh*t. In the sense that they wouldn't be better than minoxidil and finasteride.

On SM I had question marks because I couldn't relate the compound to any observational evidence in vivo. But it's already to quiet around them. I assume now it isn't going to outperform minoxidil.

Do you know what companies like to do the most in this sector? They absolutely love to release good results and flaunt with them. If they don't have good results or mediocre results they tend to hold back.

Look at this; https://www.zacksinvest.com/histogen-inc

Seems Histogen looks for funding am I correct? LMAO. ANY treatment that would reverse even a norwood or 2 or be better than minoxidil is worth more than 18 million EASILY.

But wait;



Maybe we should get Dr. Cotsarelis 2 million. Because you know that would bring out a product that is more effective than minoxidil;

giphy.gif

Not sure how valid your doubts are but is there any pre-clinical research that sounds promising to you?
 

Swoop

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Not sure how valid your doubts are but is there any pre-clinical research that sounds promising to you?

- Lauster (Berlin)
- Tsuji (Tokyo)
- Jahoda (UK).

That is research/technology that is really exciting and may hold really big things for the future. But to my knowledge these groups are not in official pre-clinical stages yet.

You are not sure of what exactly?

See this data; http://www.ishrs.org/content/ishrs-2015-practice-census-infographic.

The hair transplant industry only is soaring up to almost a $3 billion annual market. Add to that the sales of hair treatments like minoxidil, propecia and all snake oils etc. We are talking billions yearly here. Much money is to be made.

If you have any treatment/method whatsoever that can show superior effectiveness towards minoxidil. Or if you can show anything that challenges hair transplants in cosmetic results money will be literally THROWN at you in big amounts. Amounts like 18 or 2 million are laughable dude.

You don't find this sole aspect logical?

To give an example recently Allergan paid extremely much money for Kybella (hundreds of millions of dollars).

Anything that is superior to minoxidil or can challenge hair transplants is worth a ton of cash mate.

Getting to show results is the hard part, if anything we have learned that it isn't easy.
 

Swoop

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Samumed announced an increase in hair count and density within a week of their phase II. I get that they haven't officially said anything comparing it to minoxidil, but they basically said it's poised to go into Phase III. They haven't seemed like the type of company that makes a ton of noise (based on their phase I trial as well). Don't you think they could be saving announcements for a conference?

True story. I'm not that sure of SM. If they proceed to phase 3 that would be awesome. It has been a while that any hair loss treatment has reached phase 3 clinical trials (lol). We'll know very soon.
 

Pavi

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True story. I'm not that sure of SM. If they proceed to phase 3 that would be awesome. It has been a while that any hair loss treatment has reached phase 3 clinical trials (lol). We'll know very soon.

Polichem has
 
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