Idk but I've been seeing more and more people doubting Replicel. It's frustrating since I kept telling myself that I just need to maintain or stick out till ~2018, but if Replicel is a bust than there is nothing I would be even looking forward to.
That's because androgens are only half of the problemYeah. I'm depressed as hell about our possible future treatments now. Back in the summer I was hopeful about Replicel, Histogen, Seti and Swiss's PG protocol. Now it seems they're either not going to do **** or likely going to be no where near what we were hoping.
I know people joke about how the cure is always 5-10 years away, but it's frustratingly accurate. The only half effective treatment we have are anti-androgens which we've had for 25 years now. We have made next to no progress since the 90s.
I still think our most immediate hope is Samumed. They already announced it increased hair count and hair density, and their participants (or most of) had higher norwoods. Yes, they delayed the conclusion of their phase IIb, but that isn't necessarily a bad thing (if it was terrible, why not just stop?).
Nobody seems to care about a European company called polichem. They're in phase III for a topical finasteride
Nobody seems to care about a European company called polichem. They're in phase III for a topical finasteride
30 years ago we told ourselves the same thing "baldness will be cured in 5 years".
As we cut our proscar in quarters until propecia came out.
30 years later, not much has changed.
unfortunately.
Honestly, after reading some guys reporting side effects on CB 03 01, im skeptical that antiandrogenics will ever be side effects free.
Yeah, it's terrifying and I'm surprised we're just taking it up our poopholes quiety. Pretty much everything turned out to be a bust. What's there even left?
Just months ago, with all the exciting treatments in the pipeline, it felt like there was absolutely no way that a few years from now, we wouldn't have a reliable means of either regrowing or otherwise safely obtaining a full head of hair - at least for <NW4. Failure seemed practically impossible. Now suddenly, we're flooded with disappointments.
People getting no real results on seti or, at best, ones comparable to OC (decreased itch, etc.).
Bimatoprost might give only slightly better results than minoxidil if/once it comes out, which isn't really saving anyone.
Piloscopy has clearly wound down all talk of significant donor regeneration, so it's safe to assume it won't come anywhere close to providing us with a life-long supply of donor hair. Absent that, hair transplants remain a risky fix.
Histogen showed minimal regrowth with some shady photos and combovers calling everything into question.
Replicel, meanwhile, is trying to steer clear of any mention of regrowth alltogether.
While we weren't sure Replicel would offer any regrowth to begin with, there was talk of Shiseido supposedly having found a cure of sorts and for quite a while we assumed that what they had was an upgraded version of Replicel's treatment. Now that we've received confirmation it's basically the same thing, we're screwed. Maintenance only; years from now, Norwoods from now.
Not to mention the ton of other mediocre further delayed growth stimulants which will be out in like 6 years' time. Please, look forward to shelling out thousands of dollars to maintain wispy little tufts of hair. Bet that'll get us some mad tail, brah.
And not one of these companies dares to really talk about any significant Norwood-spanning regrowth. Not even talking full NW7 reversal here; none of them ever even remotely hinted at being able to regrow and fill in 2 miserable low NWs - not even with repeat treatments and/or stronger doses! Given that they are probably striving for as much good publicity as possible and generally likely to overpromise, that is telling.
And goddamn it, dat fine Ackles hairline...
I brought up the crowdfunding idea particularly with regards to Follica and he said the amount necessary is quite large. So I insisted on an actual amount and here's what he said: "US $2 million would bring out a product that would be more effective than Minoxidil and Propecia but would not give a bald person a full head of hair. US $20 million will provide the kind of funding necessary to give someone who is already bald a full head of hair but it will take more years to accomplish".
Well said Follisket, but quite frankly almost everything was extremely predictable. Especially if you are somewhat aware of hair follicle biology and just look at it from an objective standpoint.
Seti, bima, histogen. I was 100% pretty sure of them being bunk sh*t. In the sense that they wouldn't be better than minoxidil and finasteride.
On SM I had question marks because I couldn't relate the compound to any observational evidence in vivo. But it's already to quiet around them. I assume now it isn't going to outperform minoxidil.
Do you know what companies like to do the most in this sector? They absolutely love to release good results and flaunt with them. If they don't have good results or mediocre results they tend to hold back.
Look at this; https://www.zacksinvest.com/histogen-inc
Seems Histogen looks for funding am I correct? LMAO. ANY treatment that would reverse even a norwood or 2 or be better than minoxidil is worth more than 18 million EASILY.
But wait;
Maybe we should get Dr. Cotsarelis 2 million. Because you know that would bring out a product that is more effective than minoxidil;
Not sure how valid your doubts are but is there any pre-clinical research that sounds promising to you?
Samumed announced an increase in hair count and density within a week of their phase II. I get that they haven't officially said anything comparing it to minoxidil, but they basically said it's poised to go into Phase III. They haven't seemed like the type of company that makes a ton of noise (based on their phase I trial as well). Don't you think they could be saving announcements for a conference?
True story. I'm not that sure of SM. If they proceed to phase 3 that would be awesome. It has been a while that any hair loss treatment has reached phase 3 clinical trials (lol). We'll know very soon.