Any truth to RU and AR upregulation?

[hairDespair]

I recently started trying and was reading around that there is a possibility of AR upregulation resulting in hair loss getting worse later/having to up dosage. It's mostly been a lot of "I heard" kind of anecdotes, so was wondering if this was some bro science talk or actually backed up by evidence

 

[Ausgebombt]

No there is no evidence for it. There is also no evidence that RU actually works either besides anecdotes.

There were about 5 papers on RU published in the 90s and they were all studies done on animals. Besides that, there is no official information on it.

 

[hairDespair]

No there is no evidence for it. There is also no evidence that RU actually works either besides anecdotes.

There were about 5 papers on RU published in the 90s and they were all studies done on animals. Besides that, there is no official information on it.

I've seen a lot of people mentioning good success, but then again I guess it could be that they're taking other stuff. So far it's drastically reduced the itching after a couple of weeks

 

[Harleyj888]

I used Ru for about 2 weeks then stopped due to chest tightness, since stopping my hair has been shedding triple the amounts of dark normal hairs aswell as miniaturized hairs. Can only put this down to 1 of two reasons. either i have up regulated my androgen receptors in only those 2 weeks i used and now its made even worse by stopping the RU or im just shedding like most people do after starting a hairloss treatmeant. Hoping that its just a shed and will recover in 6 months.

 

[hairDespair]

I used Ru for about 2 weeks then stopped due to chest tightness, since stopping my hair has been shedding triple the amounts of dark normal hairs aswell as miniaturized hairs. Can only put this down to 1 of two reasons. either i have up regulated my androgen receptors in only those 2 weeks i used and now its made even worse by stopping the RU or im just shedding like most people do after starting a hairloss treatmeant. Hoping that its just a shed and will recover in 6 months.

That seems kind of fast to happen, but who knows. I haven't had any chest tightness, but I use and night and maybe don't notice while asleep. I've only tried a lower dose of 30mg so far

 

[jDemarco223]

There was a period where I used RU for about a year and then stopped. I don't recall having any noticeable shed when I quit. Thinking about starting it again.

 

[Selb]

Androgen deprivation should actually down regulate the receptors. But I suppose there may be an in between phase where you’re not androgen deprived but getting there, and your ARs upregulate in the meantime. It means you need to stick with it if you start it and not quit prematurely or risk stopping treatment in that upregulation phase. All of what I said is conjecture though