Anyone Know How Much Pge2 Is Safe To Use In A Topical And How Often You Can Use It?

[Screeech]

Swiss Temples advised 100mcg per ml which is like .01% if I'm not mistaken and Westonci was using 1mg in 3ml which is .033% (with the daily microneedling he did it was probably closer to .05-.1% in efficacy.)

This is seemingly an infinitesimal amount, but I'm sure Swiss Temple's had his reasons.

Also, I have this quote:

"PGE2 also suppresses T cell receptor signaling and may play a role in resolution of inflammation.
PGE2 is a potent activator of the Wnt signaling pathway. It has been implicated in regulating the developmental specification and regeneration of hematopoietic stem cells through cAMP/PKA activity."

So I'm guessing like all indiscriminate WNT agonists (which I'm guessing PGE2 is) it can have the potential to result in the development of certain cancers. As an aside, does anyone know how much WNT agonists potentially potentiate the development of cancer? Is it negligible?

I am buying 20 grams of salted seti as going through all the threads on seti on here (it was about 250 pages worth), it was obvious that the people who applied salted seti had much more success with it, as well as people just using it topically in general - salted seti is exponentially more soluble, while still having a very similar efficacy, so with the standard one you can only dissolve ~3%, where as with salted people have dissolved at least ~30%.

Keep in mind that seti (and I'm guessing fevi too) is said by Cotsarelis to only be effective in 60% of hair loss suffers due to the different physiology of hair loss, so combine that with taking it orally (where 50% of it is instantly cleared by the liver[?] and is much weaker), it's not a surprise results of people using it on here were so poor.

I believe it has a lot more potential, and if you are using a high concentration topical with salted seti it will likely mimic fevi's efficacy anyway.

Essentially no one on here bothered to use PGE2 either when they were using seti, which is the more important component of the two.

Anyway, I am buying salted seti off Alibaba today, and will use for a couple of months before adding PGE2 so I can gauge how effective it is (if at all).

Personally I don't think it's going to work for me as it's meant to be an extension of finasteride (which didn't work for me) as it targets essentially the same pathways(?), but hopefully I can get a pleasant surprise.

I think patient compliance is more the issue with seti/ pge2 being successful in the community as it is tedious having to make the stuff up daily (potentially), instead of the protocol actually being ineffective.

Keep in mind that provided you are taking finasteride or an anti-androgen (I'm using CB), you are meant to be able to keep your gains when you come off the protocol, so that offsets the nuisance of all the rigmarole somewhat.

A reminder:

3 months on seti/ pge2 with needling.

And for anyone who wants to knock Swiss Temples, he still got decent gains (as did Westonci), so it has a pretty impressive strike rate for good results from a small sample size.

Keep in mind, minoxidil with needling varies wildly, with some people getting insane results, so the more we can expand the sample size for seti/ pge2 the more it could become clear just how good this protocol is, but the numbers suggest it's pretty decent so far.

TL/DR: I'm doing 20% salted seti + pge2. Does anyone know how many mcgs of pge2 is safe to use; can it be used daily; and is it confirmed to be a WNT agonist and if so how much can it potentiate the development of cancer?

 

[StudyHacks]

Can you tell me via PM where you got your Seti from please? Seti works on PGD whereas castor oil works on PGE2 right? So the ideal combo would be Seti/Fevi+castor oil correct?

 

[Screeech]

Can you tell me via PM where you got your Seti from please? Seti works on PGD whereas castor oil works on PGE2 right? So the ideal combo would be Seti/Fevi+castor oil correct?

Yeah, seti lowers pgd2 and dino (exogenous pge2) obviously increases it; castor oil too increases pge2 as you said, but dinoprostone is better.

I haven't used their seti before but it's the only place on Alibaba selling seti sodium (salted seti) which is what you need for topical (which is the ideal method of administration): https://www.alibaba.com/product-det...ml?spm=a2700.7724838.2017115.1.b8b65fa25CVlIB

Price is about half as much as Kane (the other place to sell it [who has had confirmed quality seti by users on here, but I would imagine Alibaba is probably just as good - we shall see.])

 

[StudyHacks]

Yeah, seti lowers pgd2 and dino (exogenous pge2) obviously increases it; castor oil too increases pge2 as you said, but dinoprostone is better.

I haven't used their seti before but it's the only place on Alibaba selling seti sodium (salted seti) which is what you need for topical (which is the ideal method of administration): https://www.alibaba.com/product-det...ml?spm=a2700.7724838.2017115.1.b8b65fa25CVlIB

Price is about half as much as Kane (the other place to sell it [who has had confirmed quality seti by users on here, but I would imagine Alibaba is probably just as good - we shall see.])

Thanks very much, what vehicle do I use? Ethanol? Do you have a guide on how I create my solution?

 

[Screeech]

Thanks very much, what vehicle do I use? Ethanol? Do you have a guide on how I create my solution?

I think stemoxydine is the ideal vehicle provided the active dissolves in it - which I believe setipiprant sodium will as it's meant to be pretty soluble - as you don't need to buy any separate ingredients and mix anything up as it already meets most of the markers desired in a vehicle.

You can have a look online, there are a few different ones available depending on the country.

I use Redken stemox, which is the most easily available one in Aus, where I live.

Also, stemox is meant to increase pge2 as well, I believe, so double whammy.

And this guide I made for clascoterone (CB) should be very applicable but just replace the CB with the seti: https://www.hairlosstalk.com/interact/threads/the-cb-breezula-clascoterone-community-thread.123404/

 

[Timii]

Keep in mind that provided you are taking finasteride or an anti-androgen (I'm using CB), you are meant to be able to keep your gains when you come off the protocol, so that offsets the nuisance of all the rigmarole somewhat.

Could you explain me this one? So you're saying as soon as we notice visible regrowth we can stop using pge2?

 

[Screeech]

Could you explain me this one? So you're saying as soon as we notice visible regrowth we can stop using pge2?

Provided you're using an anti-androgen or finasteride.

I have no idea why, that's just what Swiss Temples was on record as saying.

Time will tell I guess.

 

[joni106]

Hello,
I'm thinking of starting to use pge2 topically, but only on the days I roll. Other days, I will use Minoxidil as usual. The goal is to try grow new hair follicles.
What do you think about that?

 

[Seuxin]

No, you need to use PGE2 every days with mild rolling before. EVERY DAY

 

[mannyFJ]

Swiss Temples advised 100mcg per ml which is like .01% if I'm not mistaken and Westonci was using 1mg in 3ml which is .033% (with the daily microneedling he did it was probably closer to .05-.1% in efficacy.)

This is seemingly an infinitesimal amount, but I'm sure Swiss Temple's had his reasons.

Also, I have this quote:

"PGE2 also suppresses T cell receptor signaling and may play a role in resolution of inflammation.
PGE2 is a potent activator of the Wnt signaling pathway. It has been implicated in regulating the developmental specification and regeneration of hematopoietic stem cells through cAMP/PKA activity."

So I'm guessing like all indiscriminate WNT agonists (which I'm guessing PGE2 is) it can have the potential to result in the development of certain cancers. As an aside, does anyone know how much WNT agonists potentially potentiate the development of cancer? Is it negligible?

I am buying 20 grams of salted seti as going through all the threads on seti on here (it was about 250 pages worth), it was obvious that the people who applied salted seti had much more success with it, as well as people just using it topically in general - salted seti is exponentially more soluble, while still having a very similar efficacy, so with the standard one you can only dissolve ~3%, where as with salted people have dissolved at least ~30%.

Keep in mind that seti (and I'm guessing fevi too) is said by Cotsarelis to only be effective in 60% of hair loss suffers due to the different physiology of hair loss, so combine that with taking it orally (where 50% of it is instantly cleared by the liver[?] and is much weaker), it's not a surprise results of people using it on here were so poor.

I believe it has a lot more potential, and if you are using a high concentration topical with salted seti it will likely mimic fevi's efficacy anyway.

Essentially no one on here bothered to use PGE2 either when they were using seti, which is the more important component of the two.

Anyway, I am buying salted seti off Alibaba today, and will use for a couple of months before adding PGE2 so I can gauge how effective it is (if at all).

Personally I don't think it's going to work for me as it's meant to be an extension of finasteride (which didn't work for me) as it targets essentially the same pathways(?), but hopefully I can get a pleasant surprise.

I think patient compliance is more the issue with seti/ pge2 being successful in the community as it is tedious having to make the stuff up daily (potentially), instead of the protocol actually being ineffective.

Keep in mind that provided you are taking finasteride or an anti-androgen (I'm using CB), you are meant to be able to keep your gains when you come off the protocol, so that offsets the nuisance of all the rigmarole somewhat.

A reminder:

View attachment 130558
3 months on seti/ pge2 with needling.

And for anyone who wants to knock Swiss Temples, he still got decent gains (as did Westonci), so it has a pretty impressive strike rate for good results from a small sample size.

Keep in mind, minoxidil with needling varies wildly, with some people getting insane results, so the more we can expand the sample size for seti/ pge2 the more it could become clear just how good this protocol is, but the numbers suggest it's pretty decent so far.

TL/DR: I'm doing 20% salted seti + pge2. Does anyone know how many mcgs of pge2 is safe to use; can it be used daily; and is it confirmed to be a WNT agonist and if so how much can it potentiate the development of cancer?

I thought CB was working great for ya but you want to try this possible carcinogen?