Arimidex study

[Sahar]

I've stumbled upon a study that might be of interest to guys using
Arimidex for finas\dutasteride sides...and i quote:

Males produce endogenous estrogen from testosterone via the enzyme aromatase. Previous studies have suggested a role for endogenous estrogens in cardiovascular function in men. We examined the effects of endogenous estrogen suppression via aromatase inhibition on endothelial function, systemic arterial compliance, and lipoprotein levels in healthy young men. Using a placebo-controlled double-blind randomized design, 20 healthy men, aged 18 to 32 years, were randomized to receive either the aromatase inhibitor anastrozole (1 mg) or matching placebo. Hormone, lipid levels, C-reactive protein (CRP), and homocysteine were measured. Endothelial function, determined by flow-mediated dilation of the brachial artery, and systemic arterial compliance were assessed at baseline and after 6 weeks of treatment. There was a significant decrease in 17ß-estradiol concentrations with aromatase inhibition, from 85.4±4.2 to 64.3±8.1 pmol/L (mean±SD, P=0.042). Compared with baseline, a significant decrease in flow-mediated dilation was observed in subjects taking anastrozole [median, 6.1% (range, 5.2 to 13.4) to 3.5% (2.0 to 5.7), P=0.034] but not in the placebo group. No changes were observed in nitroglycerin-induced endothelium-independent dilation in either group. There was no change in systemic arterial compliance with either aromatase therapy or placebo. There were no significant changes in lipoproteins, testosterone, DHEA, CRP, or homocysteine levels in either the anastrozole or placebo group. We conclude that suppression of endogenous estrogens with an aromatase inhibitor resulted in impairment of flow-mediated dilation without significant changes in lipoproteins, homocysteine, or CRP. Our results suggest that endogenous estrogens play a direct regulatory role in endothelial function in young healthy men.

http://circres.ahajournals.org/cgi/cont ... 93/11/1127

The scary stuff is in bold

 

[Harie]

Very interesting study...

Though, they used a 1mg/day dose, where anyone using it while on dutasteride/finasteride uses a much lower dose. Most use 0.25 - 0.50mg EOD or even 0.25 - 0.50mg E3D. Even at 0.50mg EOD it's still 4x less than the study dosage...Which may correlate to a drop of 4x in the percentages, if we can infer 1:1 relationship.

They also didn't say whether or not the participants were exercising regularly.

 

[Sahar]

OTOH, estradiol levels didn't drop nearly as much as you'll expect with a 1mg/day dose...which makes me wonder how effective is a quarter of this dose for treating sides (assuming the effect is linear).

I wish someone with half a clue will explain what are the possible consequences of decrease in flow-mediated dilation...

 

[ugh]

Endothelial dysfunction, or the loss of proper endothelial function, is a hallmark for vascular diseases, and often leads to atherosclerosis. This is very common in patients with diabetes mellitus, hypertension or other chronic pathophysiological conditions.

This would not be good...