ASCJ-9

[lithebod]

I read this on another site - Dr Lee seems to think its very promising and they are planning to going through FDA trials apparently - does anyone have any more info on this? I went to their website and it looks very encouraging!

http://www.androscience.com

They are a group of novel anti-androgens being investigated by the Androscience Corporation in San Diego. ASCJ products have the potential of being safe and very effective topical medications for defeating the action of DHT in the scalp. ASCJ is synthesized from a natural product and promotes the degradation of endogenous androgen receptors. This pharmacological mechanism differs completely from all currently available anti-androgens. In laboratory tests, topically applied testosterone induced inhibition of the hair cycle progression with prolongation of the telogen phase 50% of the time in the mouse model. Whereas anagen conversion was achieved in 100% of the mice given testosterone followed with ASCJ-9. The researchers concluded, “These preliminary observations suggest that ASCJ-9 is a potential candidate for effective and safe topical treatment of acne and male pattern baldness.â€￾*

Currently, AndroScience is conducting GLP (Good Laboratory Practice) toxicology and accumulating other preclinical data in order to file an IND (Investigational New Drug application) and proceed to Phase I and II clinical studies.

*Ching-Yuan Su “Effects of a Novel Anti-androgen on Rodent Models of Acne and Testosterone – Dependent Suppression of Hair Cycleâ€￾ presented at the summer session of the American Academy of Dermatology 2005

Richard Lee, M.D.
Regrowth, LLC

 

[newguy23]

yea i just found an article about it. I wonder when this is gonna come out.
http://www.stophairlossnow.co.uk/News/h ... ws-620.htm

 

[michael barry]

The ability to not just #block#, but to totally degrade androgen-receptor expression in a targeted area (the scalp), would be "the bomb" for hairloss.

I imagine that some fairly suprising regrowth might be able to be achieved if one used hypertrichotics (minoxidil, peptides, perhaps some emu) along with this over three or four years time.

This would be (if it indeed works) a very elegant way for young men to avoid losing their hair in the first place.

 

[DP]

define young men - those who are destined to lose hair or young as in 20's young?

 

[michael barry]

dp,

young men or men who have just started losing hair.................or even men who suspect they will develop baldness later on. They could just start using a product like this (if it works) and never worry about losing their hair. That would be terrific for all men.

I'll be glad when baldness is scientifically defeated. Life is tough...............jobs, financial security, the right career moves, pain-in-the-*** friends (sometimes), and then there is women.............the biggest headache of them all. The last thing a guy needs to worry about is his hair, but its something that bugs the pee out of us. I'd like to see it won.

 

[hair today gone tomorrow]

The ability to not just #block#, but to totally degrade androgen-receptor expression in a targeted area (the scalp), would be "the bomb" for hairloss.

I imagine that some fairly suprising regrowth might be able to be achieved if one used hypertrichotics (minoxidil, peptides, perhaps some emu) along with this over three or four years time.

This would be (if it indeed works) a very elegant way for young men to avoid losing their hair in the first place.

I thought androgen receptors constantly regenerate themselves?

 

[michael barry]

htgt,

"ASCJ is synthesized from a natural product and promotes the degradation of endogenous androgen receptors. This pharmacological mechanism differs completely from all currently available anti-androgens. In laboratory tests, topically applied testosterone induced inhibition of the hair cycle progression with prolongation of the telogen phase 50% of the time in the mouse model. Whereas anagen conversion was achieved in 100% of the mice given testosterone followed with ASCJ-9. The researchers concluded, “These preliminary observations suggest that ASCJ-9 is a potential candidate for effective and safe topical treatment of acne and male pattern baldness.â€￾*


I suppose that this product does something to the genetic expression or androgen receptor DNA or perhaps just constantly makes them degenerate themselves (if its the latter, this thing would seemingly be a weekly-type topical). It would still be terrific if the mouse model is an indication. But mice and men are different, so we'll just have to wait and see how the tests pan out. A good phase one result would be particularily encouraging.

 

[hair today gone tomorrow]

htgt,

"ASCJ is synthesized from a natural product and promotes the degradation of endogenous androgen receptors. This pharmacological mechanism differs completely from all currently available anti-androgens. In laboratory tests, topically applied testosterone induced inhibition of the hair cycle progression with prolongation of the telogen phase 50% of the time in the mouse model. Whereas anagen conversion was achieved in 100% of the mice given testosterone followed with ASCJ-9. The researchers concluded, “These preliminary observations suggest that ASCJ-9 is a potential candidate for effective and safe topical treatment of acne and male pattern baldness.â€￾*


I suppose that this product does something to the genetic expression or androgen receptor DNA or perhaps just constantly makes them degenerate themselves (if its the latter, this thing would seemingly be a weekly-type topical). It would still be terrific if the mouse model is an indication. But mice and men are different, so we'll just have to wait and see how the tests pan out. A good phase one result would be particularily encouraging.

1 every week or so is better than foam 2 everyday....

I wonder how long before we can hear anymore news on this stuff?

 

[pinkfloyd7]

is there any time frame around when this product will come out ???????? maybe within the next five years /?????

 

[DP]

ahhh - the never ending question - when is this coming out? worst part about hair loss is patience - time is hair - everyone's timeline is 5-10 years - they've been saying the same thing 5-10 years ago ... most people in here are not doctors or scientists, your guess is just as good as theirs ... we just have to sit back and wait ... it sucks reading about discoveries but never hearing the follow up ... you read about some kind breakthrough at least once every two - three months but then there is NO follow up ... however, we must keep hope, it keeps us all going ... at least it's not life threatening - there are worst things out there

 

[goata007]

ahhh - the never ending question - when is this coming out? worst part about hair loss is patience - time is hair - everyone's timeline is 5-10 years - they've been saying the same thing 5-10 years ago ... most people in here are not doctors or scientists, your guess is just as good as theirs ... we just have to sit back and wait ... it sucks reading about discoveries but never hearing the follow up ... you read about some kind breakthrough at least once every two - three months but then there is NO follow up ... however, we must keep hope, it keeps us all going ... at least it's not life threatening - there are worst things out there

Actually they are already done with phase-I trials of ASCJ-9 and will proceed with phase-II trials in august - Really Exciting!

Although I am concerned about destroying androgen receptors...wouldn't that kill the sebum glands as well? what about hair on men's face...since it would also be marketed for acne and I do have acne, what would happen if I apply it on my face? beard gone?

 

[Apoc]

Does it even have an effect on bald heads or merely on growing hair on a rat?

 

[goata007]

Does it even have an effect on bald heads or merely on growing hair on a rat?

Its a propriety herbal compound, and I'm assuming they already saw the potential in it thats why they are proceeding with human trials.

The thing I'm really surprised about is that few months ago someone posted about this drug but said they have yet to file for IND and it would then take 5-6 years for this drug to come to the market. However, they are already done with phase-I human trials and are starting phase-II trials next month - at least for me, this is really good news!

In response to my email they said that the topical cream exhibited an excellent safety profile in phase-I. I've asked few more questions, i'll post the answers here when I get a response.

 

[Jkkezh]

Interesting, keep us updated!

 

[RagingBaldy]

Man this stuff's going to take awhile.

First phase II then Phase III then FDA approval, and then marketing.

3-4 years at best? :shock: