Azelaic Acid...........small reduction in sebum: study

[michael barry]

Titre du document / Document title
Relationship between sebostatic activity, tolerability and efficacy of three topical drugs to treat mild to moderate acne
Auteur(s) / Author(s)
STINCO G. ; BRAGADIN G. ; TROTTER D. ; PILLON B. ; PATRONE P. ;
Résumé / Abstract
Background Acne is a multifactorial disorder in which the sebum plays an important pathogenetic role. Purpose of the study To evaluate the sebostatic effect of three anti-acneic ingredients (azelaic acid, adapalene and benzoyl peroxide) conveyed in cream and to determine whether there is a correlation with the therapeutic results. Materials and methods Sixty-five patients with mild or moderate acne localized on the face were divided into three therapy groups at random: 25 applied azelaic acid once a day, 20, benzoyl peroxide and 20, adapalene. All the patients were observed at the time of enrolling and a further four times at fortnightly intervals. At each visit the sebum casual level on the forehead, chin and one cheek was measured using a sebumeter. Furthermore, side-effects and clinical-therapeutic effectiveness were noted. Results Four patients did not complete the study. Azelaic acid showed an average reduction of 13.9% in sebum production on the forehead, 14.2% on the chin and 15.2% on the cheek. Benzoyl peroxide caused an increase of 10.5% in sebum production on the forehead, 10.3% on the chin and 25.4% on the cheek. Adapalene reduced sebaceous secretion by 0.2% on the forehead and 6.7% on the cheek whereas sebum production increased by 6.2% on the chin. All three drugs showed a clinical improvement in the acneic lesions with moderate adverse effects. Conclusion The three topical drugs bring about good therapeutic results with scarce side-effects that do not, however, seem to be correlated with the sebostatic activity.
Revue / Journal Title
JEADV. Journal of the European Academy of Dermatology and Venereology (JEADV, J. Eur. Acad. Dermatol. Venereol.) ISSN 0926-9959
Source / Source
2007, vol. 21, no3, pp. 320-325 [6 page(s) (article)]
Langue / Language
Anglais

Editeur / Publisher
Blackwell , Oxford, ROYAUME-UNI (1992) (Revue)

Mots-clés d'auteur / Author Keywords
acne ; adapalene ; azelaic acid ; benzoyl peroxide ; sebumeter ;
Localisation / Location
INIST-CNRS, Cote INIST : 27191, 35400014557962.0040




The percentages aren't much..................but they are something

 

[JWM]

Wait until Bryan sees this :shock:

 

[philly]

...

 

[Follically Challenged]

Michael Barry, if anyone here deserves the C. Montgomery Burns Award for Outstanding Achievement in the Field of Excellence, it's you.

 

[LookingGood!]

This study has to do w acne. How is it relevant to hairloss?

 

[michael barry]

Looking good,

Sebum production in the sebaceous gland is under androgenic control. If you get castrated, you produce very little sebum. Children and women produce very little sebum. Give them testosterone shots and they produce just as much as men do, and the glands enlarge.

Type one alpha five reductase is present in the sebaceous gland, and reducing secretions by 15% or so would indicate that although not a receptor blocker, that azelaic acid might at least be a mild inhibitor of type one 5AlphaReductase. There is no evidence that it inhibits type two (the important enzyme located in the innermost portion of your outer root sheath or all your hair follicles). We know that dutasteride inhibits type one at about 50%, but I dont know if any sebum secretion study has been done with dutasteride. It would be wonderful and great and super if azelaic acid was found to inhibit type two...........but it doesn't look likely. What is so frustrating about researching hairloss is the lack of testing. Youd think that one medical group would test about 20 things topically like azeliaic acid and licorice and see if hair counts and hairweights and photographic assessment indicated efficacy, but no one has----so we have to divine from little tests like this which is of course dissapointing.

 

[RAKBS]

Benzoyl peroxide caused an increase of 10.5% in sebum production on the forehead, 10.3% on the chin and 25.4% on the cheek.

I think I'm goint to post this over on the acne.org message boards.

 

[michael barry]

Bryan has posted 4 studies at Hairsite showing that AA didnt effect sebum. The studies contradict the one I found.


As for now, since four is more than one.....................although bewildering Id say its definitely best to research OTHER anti-androgens that Azelaic Acid for the time being. Even if the stuy I postes was correctly carried out, the percentages aren't all that high (15%, etc.).


Im testing cedarwood personally. I think revivogen is a pretty good anti-androgen as well as fluridil personally