Someone posted to one of the threads saying besides the skin, another big source of 5AR1 is in the brain. He said dutasteride is unpredictably dangerous and only suibable for men who have to pee 4x per night. I've read many pages that list the 5AR sources, and none of them listed the brain. I hope that poster will post his sources here.
Bryan, is 5ARI in the brain?
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wookster
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I issued a warning
I issued a warning on my myspace blog.
"That link says that 5AR1 is in the brain, so inhibitting it could have unknown neurological results. Propecia does not have this issue. Look at the graph in my main picture and see the blood concentration where 5AR1 first gets inhibitted. I think this is at 70% dht inhibition. This corresponds to 0.1mg/day. Do not take more than that. However, if you apply that much topically, you may be able to inhibit the 5AR1 in your scalp and not affect the 5AR1 in your brain because it will be diluted once it passes through the heart to the brain."
If absorbed 60% (the same as in the intestine), that would be 6 capsules in minoxidil per month, though I think 3-4 is more than addequate.
Bryan. I know you think dutasteride absorption is speculation, but what do you think of my reasoning as far as safety is concerned? Have you seen the graph on my site? :
I think if 0.05 mg/day enters the scalp and then the blood and goes to the heart (via veins, not arteries, so it does not hit the brain first, and the skull is protecting it from the scalp) it would then be diluted before going to the rest of the body. I think since 0.1 mg/day reaches a steady state concentration that inhibits 70% of serum DHT, and the graph shows that when 70% of DHT is inhibitited, all of it is from 5AR2 if it is taken orally. I think the diluted stuff from the scalp would be the same, but that the scalp would get a high concentration where both 5AR's are inhibitted. And if dutasteride does not pentetrate the scalp, then there is no danger. Just take some propecia as a back up until you see great results and know you can stop the propecia.
I issued a warning on my myspace blog.
"That link says that 5AR1 is in the brain, so inhibitting it could have unknown neurological results. Propecia does not have this issue. Look at the graph in my main picture and see the blood concentration where 5AR1 first gets inhibitted. I think this is at 70% dht inhibition. This corresponds to 0.1mg/day. Do not take more than that. However, if you apply that much topically, you may be able to inhibit the 5AR1 in your scalp and not affect the 5AR1 in your brain because it will be diluted once it passes through the heart to the brain."
If absorbed 60% (the same as in the intestine), that would be 6 capsules in minoxidil per month, though I think 3-4 is more than addequate.
Bryan. I know you think dutasteride absorption is speculation, but what do you think of my reasoning as far as safety is concerned? Have you seen the graph on my site? :
I think if 0.05 mg/day enters the scalp and then the blood and goes to the heart (via veins, not arteries, so it does not hit the brain first, and the skull is protecting it from the scalp) it would then be diluted before going to the rest of the body. I think since 0.1 mg/day reaches a steady state concentration that inhibits 70% of serum DHT, and the graph shows that when 70% of DHT is inhibitited, all of it is from 5AR2 if it is taken orally. I think the diluted stuff from the scalp would be the same, but that the scalp would get a high concentration where both 5AR's are inhibitted. And if dutasteride does not pentetrate the scalp, then there is no danger. Just take some propecia as a back up until you see great results and know you can stop the propecia.
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Re: I issued a warning
I totally agree with your reasoning as far as safety is concerned. I don't agree, however, with the general idea of using topical dutasteride (or finasteride, for that matter). Trying to "guesstimate" how effective topical dutasteride would be is about like trying to calculate how many angels can dance on the head of a pin! :wink: Neither do I feel that inhibiting 5a-reductase type 1 in the scalp is all that important.
That one from Gisleskog that I modified?? Sure...
Bryan
collegechemistrystudent said:
I totally agree with your reasoning as far as safety is concerned. I don't agree, however, with the general idea of using topical dutasteride (or finasteride, for that matter). Trying to "guesstimate" how effective topical dutasteride would be is about like trying to calculate how many angels can dance on the head of a pin! :wink: Neither do I feel that inhibiting 5a-reductase type 1 in the scalp is all that important.
collegechemistrystudent said:
That one from Gisleskog that I modified?? Sure...
Bryan