I don't know if I saw two small hair loss studies with dutasteride, or if one of them was the abstract and one of them showed the details. Both said dutasteride doses of 0.5 and 2.5mg/day grow more hair total than proscar does, but it is mainly in the crown and top, and that these high doses grow less hair in the temples. And 0.1mg/day dutasteride is almost identical to proscar except for the high half life. Some people said it grows more in the sides, making the temples look thin, but I know in the studies they actually counted hairs instead of just judging cosmetically.
Since DHT is so much more potent than testosterone, and the high doses have a large scalp DHT inhibitioin, why would the temples regrow less hair with high dutasteride doses than with high finasteride doses? If I somehow make a topical that gives my scalp a high dose of Dutasteride, will I be hurting my hair line and temple hairs? This makes no sense. The difference I see is that dutasteride inhibits 5ar1 at these higher doses and has more testosterone, which is much weaker than DHT and would have been DHT if 5ar was not inhibited. I wonder of 20 mg finasteride would do for the temples, or where I could see a study comparing section by section hair growth of finasteride 0.2mg/day, 1 and 5mg/day.
Since DHT is so much more potent than testosterone, and the high doses have a large scalp DHT inhibitioin, why would the temples regrow less hair with high dutasteride doses than with high finasteride doses? If I somehow make a topical that gives my scalp a high dose of Dutasteride, will I be hurting my hair line and temple hairs? This makes no sense. The difference I see is that dutasteride inhibits 5ar1 at these higher doses and has more testosterone, which is much weaker than DHT and would have been DHT if 5ar was not inhibited. I wonder of 20 mg finasteride would do for the temples, or where I could see a study comparing section by section hair growth of finasteride 0.2mg/day, 1 and 5mg/day.
