I am aware it has been discussed a lot about this issue on this as well as other hair loss forums, but I think we all want to learn more about this aspect. As new finasteride user I am actually worried, do we with this drugs induce more sensitivity of hair to our androgen hormons ?
Do you think, 5ard inhibitors can increase an androgen receptor sensitivity (upreglation of AR) , etc. hair follicles become more sensitive and get used to lower levels of DHT circulated in blood flow. That would explain why some people experienced accelerated hair loss immediately after discontinuation of finasteride or dutasteride even before ceasing their hair loss was halted or was stabilized. Apparently, reason is as DHT level quickly goes up two or three days after last pill, follicles which have been years in low DHT state, are then attacked literally by increased level of DHT. Another possible clue which was reported by some long term finasteride users, is there was lack of efficacy of these drugs after 5,10 or more years. Of course, it’s possible their hair loss become more aggressive due to naturally increase in 5-alfa-reductase in their body. On the other hand, no matter in what age you start and how initially your male pattern baldness aggressive is, doses such as: 1 mg, 1.25 mg, in most cases significantly slow or even halt hair loss. And as time goes up many users, especially those with aggressive AA must upper the dose after particular time (some after just a year, or even less, some after 4,5 years or more) to remain results . That would mean there is correlation between efficacy of the dose and duration of usage of that dose. What I mean is, I do not believe our body rapidly start to produce more 5ard enzymes after relatively short time periods such as a year, two, three or even five . Or maybe I am wrong. I realize that if someone is using finasteride for let's say 10 years, then his body produce more 5ard in his 35 then in age when he was 25 years old when started with finasteride. In that sense 10 years time frame means a lot in endocrinology aspect, but I believe periods of time less than 5-10 years, typically can not result in such great differences of produced levels of 5ard.
So, when finasteride or dutasteride lose their efficacy during the time, is it because:
What do you think which factor contributes most to eventual decrease in effectiveness of dutasteride and finasteride after some period of time, and is it possible DHT inhibitors(finasteride, dutasteride) can cause UPREGULATION of AR?
Do you think, 5ard inhibitors can increase an androgen receptor sensitivity (upreglation of AR) , etc. hair follicles become more sensitive and get used to lower levels of DHT circulated in blood flow. That would explain why some people experienced accelerated hair loss immediately after discontinuation of finasteride or dutasteride even before ceasing their hair loss was halted or was stabilized. Apparently, reason is as DHT level quickly goes up two or three days after last pill, follicles which have been years in low DHT state, are then attacked literally by increased level of DHT. Another possible clue which was reported by some long term finasteride users, is there was lack of efficacy of these drugs after 5,10 or more years. Of course, it’s possible their hair loss become more aggressive due to naturally increase in 5-alfa-reductase in their body. On the other hand, no matter in what age you start and how initially your male pattern baldness aggressive is, doses such as: 1 mg, 1.25 mg, in most cases significantly slow or even halt hair loss. And as time goes up many users, especially those with aggressive AA must upper the dose after particular time (some after just a year, or even less, some after 4,5 years or more) to remain results . That would mean there is correlation between efficacy of the dose and duration of usage of that dose. What I mean is, I do not believe our body rapidly start to produce more 5ard enzymes after relatively short time periods such as a year, two, three or even five . Or maybe I am wrong. I realize that if someone is using finasteride for let's say 10 years, then his body produce more 5ard in his 35 then in age when he was 25 years old when started with finasteride. In that sense 10 years time frame means a lot in endocrinology aspect, but I believe periods of time less than 5-10 years, typically can not result in such great differences of produced levels of 5ard.
So, when finasteride or dutasteride lose their efficacy during the time, is it because:
- There is more 5-alfa-reductase producing in body (as result of aging process or some kind of feedback mechanism - body realize there is decrease in DHT level, and start to produce more 5ard)
- AR become more sensitive
- Combination between above two statements
- Possible other unknown factors as change in auto-immune response, fibrosis etc. which are also included in AA and are not yet fully understood.
What do you think which factor contributes most to eventual decrease in effectiveness of dutasteride and finasteride after some period of time, and is it possible DHT inhibitors(finasteride, dutasteride) can cause UPREGULATION of AR?
I started with finasteride at 19 and it didn't work, tried oral spironolactone for about 7 months and it just caused a terrible shed. Been on oral minoxidil for 10 months with a few months of regrowth but that all shed and more so my hair looks like crap now. Can't style it the way I used to without using seasalt spray and a thickening shampoo, even then it still doesn't look the way it used to. Now I've added in androdur and some low dose oral and topical esteogen about 2 months ago, still losing my hair. Been treating my hairloss for almost 2 years and I've lost more hair in that time than I had before treatments.
