Just Incase this has not been discussed, I thought I would throw it out there for the scientific hyenas. Also I'll be starting this treatment for allergy symptoms next week, so I will do my best to observe any changes.
According to my allergist, a good adjunct therapy to my Claritin regimen is the supplementation of - Nutrilite Cleargaurd; http://www.amway.com/AustUS/Shop/Product/Category.aspx/Nutrilite
Apparently it is widely recognized in the allergy world that this combination therapy of Cinnamomum zeylanicum, Malpighia glabra, and Bidens pilosa, is a pretty effective mast cell stabilizer, histamine antagonist, and PDG2 moderator. I understand this very well be just another useless list of natural compounds that either does absolutely nothing or does have some effect, but not enough to make a cosmetic or effective dent in Androgenetic Alopecia. But having said that, regardless of its ability to interfere in Androgenetic Alopecia, this is not a feel good supplement, this is an extremely well researched treatment for allergies. It is also recommended by every allergist I've seen so far making me think that there is medical merit to it for something at the very least.
Now I have no idea how PDG2 is actually involved in the degradation of a hair follicle, only that it is over-expressed in scalp regions affected by Androgenetic Alopecia and somehow tied to inflammation. What I do know is that when I take chilled urine or blood plasma allergy tests, I have higher then average levels of PDG2 and histamine indicators. This I know for a universal fact causes me chronic immuno-inflammatory response as well as general allergic rhinitis symptoms. I will comparing that blood test after I start this supplement.
Several studies have been done comparing the allergy symotom relief comparison between this Natural combo, and the major allergy meds; Claritin & Zyrtec. People using topical cetrizine might find it interesting that in every double blind study, the combination of these three botanicals underperformed in mediating allergy symptoms, but outperformed bother Claritin and Zyrtec in regards to PDG2 mediation. As my doctor explained it to me.. When something occurs within the body that would otherwise cause PDG2 to elevate, the effects of these botanicals prevents any fluctuation almost entirely, both reducing it slightly and maintaining its stable levels.
Study of efficiency vs Claritin;
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2491648/
"While the immediate, or early nasal response to allergen provocation was not affected by the botanical preparation, we did note a significant reduction in nasal symptom scores during the 8 hour time period following nasal challenge. The most likely explanation for this was the apparent reduction in increased PGD2 secretion in the CBP-treatment"
Make of it what you will, I'm not here suggesting I've found the natural cure. Maybe there's merit to formulating a topical combo of these botanicals? Maybe this is the best natural PDG2 supplement available to us? or maybe it's entirely useless.
According to my allergist, a good adjunct therapy to my Claritin regimen is the supplementation of - Nutrilite Cleargaurd; http://www.amway.com/AustUS/Shop/Product/Category.aspx/Nutrilite
Apparently it is widely recognized in the allergy world that this combination therapy of Cinnamomum zeylanicum, Malpighia glabra, and Bidens pilosa, is a pretty effective mast cell stabilizer, histamine antagonist, and PDG2 moderator. I understand this very well be just another useless list of natural compounds that either does absolutely nothing or does have some effect, but not enough to make a cosmetic or effective dent in Androgenetic Alopecia. But having said that, regardless of its ability to interfere in Androgenetic Alopecia, this is not a feel good supplement, this is an extremely well researched treatment for allergies. It is also recommended by every allergist I've seen so far making me think that there is medical merit to it for something at the very least.
Now I have no idea how PDG2 is actually involved in the degradation of a hair follicle, only that it is over-expressed in scalp regions affected by Androgenetic Alopecia and somehow tied to inflammation. What I do know is that when I take chilled urine or blood plasma allergy tests, I have higher then average levels of PDG2 and histamine indicators. This I know for a universal fact causes me chronic immuno-inflammatory response as well as general allergic rhinitis symptoms. I will comparing that blood test after I start this supplement.
Several studies have been done comparing the allergy symotom relief comparison between this Natural combo, and the major allergy meds; Claritin & Zyrtec. People using topical cetrizine might find it interesting that in every double blind study, the combination of these three botanicals underperformed in mediating allergy symptoms, but outperformed bother Claritin and Zyrtec in regards to PDG2 mediation. As my doctor explained it to me.. When something occurs within the body that would otherwise cause PDG2 to elevate, the effects of these botanicals prevents any fluctuation almost entirely, both reducing it slightly and maintaining its stable levels.
Study of efficiency vs Claritin;
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2491648/
"While the immediate, or early nasal response to allergen provocation was not affected by the botanical preparation, we did note a significant reduction in nasal symptom scores during the 8 hour time period following nasal challenge. The most likely explanation for this was the apparent reduction in increased PGD2 secretion in the CBP-treatment"
Make of it what you will, I'm not here suggesting I've found the natural cure. Maybe there's merit to formulating a topical combo of these botanicals? Maybe this is the best natural PDG2 supplement available to us? or maybe it's entirely useless.
