College Chem

[JWM]

Here's a thought for you:

The reason so many people experience frontal thinning on dutasteride is because the drug is SO powerful as the standard .5 dose that it causes some sort of upregulation of sorts in the body and hormones go haywire (don't be jealous of my creative terminology)

Perhaps most, especially those who are below NW3s would be better of starting off at your suggested dose of 2 capsules a week to see how they fair, while adding a topical AA for safety purposes.

 

[CCS]

Perhaps, but i don't think AA is good. I think GLA, ALA and linoleic acid (not to be confused with oils, which are the acids bonded to glycerol) are a much better choice than AA.

It is interesting whether the body does up regulate testosterone in response, or if the increased testosterone is just from DHT that is not formed. I'm sure those measurements were already taken. I have seen some on some sights. We just need to surf the web and find them.

A very attractive aspect of 3x per week for me is the lower cost, and knowing the 5ar1 in my brain is not affected. But since all my thinning is in the front, i want to find that web site I saw before and show it to Bryan before I just trust him that there were no other studies or that they did not test the front and just not report it as widely.

 

[Goingat20]

A very attractive aspect of 3x per week for me is the lower cost, and knowing the 5ar1 in my brain is not affected.

3x a week doesnt affect the brain? Also wont your chances of regaining hair decline?

 

[CCS]

yes, they will decline. But I can buy more topicals with the money I would spend on dutasteride.

3x per week should inhibit about 15% of DHT production in the brain, compared to 50% by 7x per week, and about 3% by 1x per week.

 

[Bryan]

It is interesting whether the body does up regulate testosterone in response, or if the increased testosterone is just from DHT that is not formed.

Everybody on these hairloss forums has always assumed that it's the latter case (that finasteride and dutasteride raise testosterone levels simply because less of it is being metabolized into DHT). However, I've been trying to fight that simplistic notion for a long time, although without much success. In my opinion, it's a true upregulation of testosterone production. I think the dead give-away for that is that LH and FSH levels in the blood rise to about the same degree as testosterone. The brain is seeing the sharp decrease in DHT, and sending out the chemical signals to the testes to step-up testosterone production in response.

A very attractive aspect of 3x per week for me is the lower cost, and knowing the 5ar1 in my brain is not affected. But since all my thinning is in the front, i want to find that web site I saw before and show it to Bryan before I just trust him that there were no other studies or that they did not test the front and just not report it as widely.

I wish you good luck on finding that other alleged study! I've been reading about dutasteride for years, collecting various studies on it, reading and posting about it on several hairloss sites, and I have never (I repeat: NEVER) seen anything about an alleged study which supposedly tested dutasteride on the temples or the front hairline. I really do think what you saw was just the well-known Glaxo trial, and you're mis-remembering what it said.

Bryan

 

[JWM]

College, when I say AA I mean antiandrogen, not Az Acid.