Costarialis new patent for hairloss, acne, rosacea, prostate

[michael barry]

http://www.wipo.int/pctdb/en/wo.jsp?ELE ... SPLAY=DESC



"(WO/2007/149312) METHODS AND COMPOSITIONS FOR INHIBITING OR REDUCING HAIR LOSS, ACNE, ROSACEA, PROSTATE CANCER, AND BPH"


That is the title of the patent.



The patent focuses on inhibiting the action of prostaglandin D2 by inhibiting its production or reception via its receptor site. PGD2 is 4.4 times more prevalent in balding scalp than hairy scalp. Shaved mice can have their next growth phase inhibited perpetually with topical application of this substance. The patent makes for interesting reading
....................apparently alot of inflammatory substances are upreged around this particular prostaglandin in androgen-related disorders and Costarialis and his co-counder (long name on that dude) feel its some sort of "lynchpin" in androgen related disorders.


As CollegeChemistryStudent pointed out, DHT is only about twice as prevalent in balding scalp than hirsute scalp, so 4.4 times more Prostaglandin D2 presence in balding scalp and bald scalp over hirsute scalp is even more of a correlation in mathematical terms than DHT, so there really may be a link in the process even if its not total in causality.





Consequently, green tea inhibits some prostaglandin D2 expression:



From PubMed:"
1: Prostaglandins Leukot Essent Fatty Acids. 2004 Jul;71(1):25-31. Links
Antiplatelet effect of green tea catechins: a possible mechanism through arachidonic acid pathway.
Son DJ, Cho MR, Jin YR, Kim SY, Park YH, Lee SH, Akiba S, Sato T, Yun YP.
College of Natural Sciences, Soonchunhyang University, Asan 336-745, South Korea.

We have previously reported that green tea catechins (GTC) showed an antithrombotic activity, which might be due to antiplatelet effect rather than anticoagulation. The present study was performed to investigate the effect of GTC on the arachidonic acid (AA) metabolism in order to elucidate a possible antiplatelet mechanism. GTC inhibited the collagen-, AA- and U46619-induced rabbit platelet aggregation in vitro in a concentration-dependent manner, with IC50 values of 61.0+/-2.5, 105.0+/-4.9 and 67.0+/-3.2 microg/ml, respectively. Moreover, GTC administered orally into rats inhibited the AA-induced platelet aggregation ex vivo by 46.9+/-6.1% and 95.4+/-2.2% at the doses of 25 and 50 mg/kg, respectively. [3H]AA liberation induced by collagen in [3H]AA incorporated rabbit platelets was significantly suppressed by GTC compared to the control. GTC also significantly inhibited the thromboxane A2 (TXA2) and prostaglandin D2 (PGD2) generations induced by addition of AA in intact rabbit platelets. GTC significantly inhibited TXA2 synthase activity in a concentration-dependent manner. Moreover, adenosine triphosphate (ATP) release from dense granule was inhibited by GTC in washed platelets. These results suggest that the antiplatelet activity of GTC may be due to the inhibition of TXA2 formation through the inhibition of AA liberation and TXA2 synthase. Copyright 2004 Elsevier Ltd.

PMID: 15172681 [PubMed - indexed for MEDLINE]"

 

[harold]

Actually that figure of 4.4 was only from 1 individual where they used mass spdectrometry to verify the findings in 3 individuals their was an average 11.6 fold increase in balding areas over non-balding areas. Thats a lot. Its unclear if 4.4 is the more accurate figure - I think it was a more accurate technique. At any rate its overexpressed.

PGD2 was elevated in all bald samples, 15 at an average fold increase of 11.6 (Figure 7B). This increase in PGD2 was verified in 1 individual by mass spectrometry. PGD2 was detected as 17 pg/mg of tissue in haired scalp and 75.5 pg/mg in bald scalp, representing a 4.4 fold increase in bald tissue.

Not sure if green tea would have the same effects on PGD2 levels in hair follicles as it would in platelets. But thats kind of irrelevant since it has been shown to promote hair growth.
hh

An animal study to back up the human in vitro one.

J Natl Med Assoc. 2005 Aug;97(8):1165-9.Links
The effects of tea polyphenolic compounds on hair loss among rodents.
Esfandiari A, Kelly AP.

Department of Otolaryngology, Charles R. Drew University of Medicine and Science, USA. adesfand@cdrewu.edu

The objective of this study was to examine the effects of polyphenolic compounds, present in noncommercially available green tea, on hair loss among rodentts. In an experimental study, we randomly assigned 60female Balb/black mice, which had developed spontaneous hair loss on the head, neck and dorsal areas into two equal groups; A (experimental) and B (control). Group A received 50% fraction of polyphenol extract from dehydrated green tea in their drinking water for six months. Group B received regular drinking water. Both groups were fed regular rodent diets (Purina Rodent Chow 5001) and housed individually in polycarbonate cages. The results showed that 33% of the mice in experimental Group A, who received polyphenol extract in their drinking water, had significant hair regrowth during six months of treatment (p = 0.014). No hair growth was observed among mice in the control group, which received regular water.

Only tangentially related but interesting

J Cosmet Sci. 2007 Jul-Aug;58(4):369-74.Links
Can a topical scalp treatment reduce hair bulb extraction?
Gruber JV, Bouldin L, Lou K.

Arch Personal Care, 70 Tyler Place, South Plainfield, NJ 07080, USA.

Generally speaking, when people talk about "hair breakage" they are typically referring to the idea that as they comb or brush their hair, the fibers are elongating and snapping at some weak point in the fiber length. It is well established that as people chemically treat their hair, the keratin proteins are degraded further and the hair become more brittle and susceptible to breakage. For the consumer, hair breakage is registered as hair fibers noted in their comb or brush, and in the drain that they see after a cosmetic treatment. However, a fundamental question that needs to be asked is whether or not the hairs that are seen in the drain are really the result of hair breakage (i.e., a fiber snapping) or are they the result of hairs that are actually being extracted from the scalp by their root bulbs. If the bulk of the hair fibers are actually extracted by the bulb, than it seems somewhat superfluous to try and improve hair strength by improving the exterior of the fiber. The fiber is dead and topical treatments can only smooth, and possibly moisten already established fiber structure and integrity. This paper will attempt to address hair strength by looking at the scalp and follicle as the target for treatment, showing that topical application of a product containing a blend of well-known skin active ingredients can demonstrate potential reductions in hair extractions. An in vivo testing protocol in which 15 voluntary participants with at least 12" hair length were professionally shampooed, and then treated, half-head, with a commercial conditioner, or the same conditioner that contained 5% of a mixture of yeast peptides, fruit acids and green tea polyphenols every day for five days will be discussed. At the beginning and end of the treatment period, the number of hairs that either broke along the fiber, or extracted by the bulb were gathered, separated and counted for both the treated and untreated side of the head. The results of this one-week study demonstrate that the number of hairs that actually break pales in comparison to the number of hairs that are extracted complete with intact root bulb from the follicle.

 

[elguapo]

Are they applying green tea topically, or will ingesting (drinking) green tea do the trick as well?

 

[oyo]

My guess is you'd have to take an awful lot of gte to get a hair benefit, since it is significantly metabolized by the liver. Also, systematic anti-androgenic effects don't seem to be commonly seen for tea drinkers

Dose-dependent incorporation of tea catechins, (-)-epigallocatechin-3-gallate and (-)-epigallocatechin, into human plasma.

Nakagawa K, Okuda S, Miyazawa T.

Food Chemistry Laboratory, Faculty of Agriculture, Tohoku University, Sendai, Japan.

Tea catechins, (-)-epigallocatechin-3-gallate (EGCg) and (-)-epigallocatechin (EGC), have been reported to suppress oxidation of plasma low density lipoprotein (LDL) in vitro. If dietary catechins can be efficiently incorporated into human blood plasma, anti-atherosclerotic effects in preventing oxidative modification of LDL would be expected. In this study, a newly developed chemiluminescence detection-high pressure liquid chromatography (CL-HPLC) method for measuring plasma catechins was used and the incorporation of EGCg and EGC into human plasma was investigated. Healthy subjects orally ingested 3, 5, or 7 capsules of green tea extract (corresponding to 225, 375, and 525 mg EGCg and 7.5, 12.5, and 17.5 mg EGC, respectively). The plasma EGCg and EGC concentrations before the administration were all below the detection limit (< 2 pmol/ml), but 90 min after, significantly and dose-dependently increased to 657, 4300, and 4410 pmol EGCg/ml, and 35, 144, and 255 pmol EGC/ml, in the subjects who received 3, 5, and 7 capsules, respectively. Both EGCg and EGC levels detected in plasma corresponded to 0.2-2.0% of the ingested amount. Catechin intake had no effect on the basal level of endogenous antioxidants (alpha-tocopherol, beta-carotene, and lycopene) or of lipids in plasma. These results suggested that drinking green tea daily would contribute to maintain plasma catechin levels sufficient to exert antioxidant activity against oxidative modification of lipoproteins in blood circulation systems.
http://www.ncbi.nlm.nih.gov/pubmed/9438 ... t=Abstract

also this is a free fulltext on black tea's effect on catechin levels, good read.
http://jn.nutrition.org/cgi/content/full/131/6/1731

 

[michael barry]

Topically is how the patent was using the GTE, and that is by far what I'd suggest. ON a hydrated scalp because it will penetrate much better that way.

 

[patagonia]

Hi Michael,

wanted to send you a hi-five unk: for this one! thanks for the effort in
searching for a good anti-andro to compliment our regimens.

I was wondering what you suggest we do
with our GTE/EGCG topicals and stabilization issues?

Would we have to keep them in the refrigerator?

What % you recommend of water and ethanol?

any tips to maximize its efficacy?

best,
patagonia

 

[Fena2000]

I have rosacea/SD and I'm also on a rosacea forum. A lot of women (including me)and men seem to have problems with really oily skin and hairloss (scalp, eyebrows and eyelashes). Nobody has any clue why this is happening. A lot of them seem to think it's demodex mites or a fungus causing this. Can anybody help us figuring out why?

 

[Quadzilla99]

How is OP red? He was always one of the best posters on here

 

[resu]

Only 5 more years guys!

 

[2bald2young]

I have rosacea/SD and I'm also on a rosacea forum. A lot of women (including me)and men seem to have problems with really oily skin and hairloss (scalp, eyebrows and eyelashes). Nobody has any clue why this is happening. A lot of them seem to think it's demodex mites or a fungus causing this. Can anybody help us figuring out why?

It is possible that demodex mites or a fungus is causing it, maybe ketoconazole can help against it. Have you tried that?

 

[Fena2000]

Yes I did, and many others on the rosacea site did. They have tried everything, but nothing seems to stop the hair loss. Some seem to think the eyebrows and eyelashes are also affected by DHT.

 

[2bald2young]

Yes I did, and many others on the rosacea site did. They have tried everything, but nothing seems to stop the hair loss. Some seem to think the eyebrows and eyelashes are also affected by DHT.

Maybe an autoimmune problem? Where your immune system attacks your hair follicle?

 

[Fena2000]

Maybe an autoimmune problem? Where your immune system attacks your hair follicle?

Is a possibility, I guess.

 

[Iwantmyhairbacknow]

tired from waiting !!!!!!!!!!! always a new research...