sizzlinghairs
Established Member
- Reaction score
- 2
Hey guys. So I have been using mico for 3 weeks now twice a day and I believe Im seeing some thickening.. Using the daktarin brand. I would really love to keep using but I have been getting some mild eye bluriness/haziness which seems to come and go.
I cant use minoxidil or Propecia so the mico benefits really excited me but the eye effects make me weary of further use. Thing is I kind of had some haziness before using mico, so maybe the nitrate is making it worse and not causing it. When I stop using it still remains but seemingly to a lesser degree.
ANYways, here is the link to the study. I have cut out two parts to get to the jist of whats going on.
http://archopht.ama-assn.org/cgi/reprint/100/9/1504.pdf
COMMENT
Fungal endophthalmitis is a serious
disease that usually destroys the eye.
Its treatment is often hindered
because only a few antifungal agents
are currently available, these agents
are toxic, and their ocular penetration
is extremely poor. In 1975, Jones5
reported the successful treatment of
Paecilomyces gougerotii dacryocysti-
tis with topical and IV miconazole,
and Aspergillus corneal ulcer with 1%
topical miconazole base in peanut oil.
This antifungal agent has also been
used for vaginal candidiasis6 and
extraocular Aspergillus infections.7
Intravitreous injection of antibiot¬
ics and closed vitrectomy have recent¬
ly been advocated for management of
endophthalmitis.9 Our goal in under¬
taking the experiments reported here¬
in was to determine whether micona¬
zole can be safely used as an intravit¬
reous injection or as an antimycotic
agent incorporated in the vitrectomy
infusion system during closed vitrec¬
tomy for fungal endophthalmitis. Our
results in rabbits show that both
miconazole nitrate and its vehicle
produce toxic damage to the retina
and crystalline lens in concentrations
of 100 Mg or greater, and that concen¬
trations ranging from 10 to 80 Mg
produce mild to moderate retinal
changes. However, the pattern of reti-
notoxicity appears somewhat irregu¬
lar, which may be due to variations in
the state of the vitreous gel among the
animals studied. We suspect that
formed vitreous may concentrate the
drug in a localized area of the vitreous
cavity and retina. Liquefied vitreous
may allow uniform dispersion of the
drug throughout the vitreous and ret¬
ina. This hypothesis may account for
the absence of retinal toxicity in doses
below 80 Mg in owl monkeys, which
normally have liquid vitreous. Retinal
delicacy or inherent susceptibility to
physical or chemical trauma may also
account for the marked differences
between the data collected in rabbits
and those obtained from monkeys.
The data in Table 6 reflect a widely
variable pattern of toxic retinal
changes at various drug dosage levels. Note, for example, while retinal changes developed in only one of four
eyes injected with 100 Mg of micona¬
zole nitrate (and these changes were
graded by our pathologist as "moder¬
ate"), histopathologic evidence of reti¬
nal damage developed in three of the
four eyes injected with only 20 Mg of
drug, and two of these three eyes
exhibited "severe" changes. We are
greatly encouraged by the fact that
clinically, electrophysiologically, and
histopathologically, miconazole ni¬
trate in doses up to 80 Mg appears to be
relatively well tolerated by the mon¬
key retina.
We are aware of only one report10
that described the use of 10 Mg of
miconazole nitrate for amphotericin
B- and flucytosine-resistant fungal
endophthalmitis caused by Paecilo-
myces lilacinus. The successful out¬
come of this case10 and our lack of
clinical, ERG, and histopathologic
evidence of retinal toxicity in owl
monkey eyes given less than 80 Mg of
miconazole nitrate justify the consid¬
eration of this antimycotic agent for
use in desperate cases of fungal
endophthalmitis. In such cases, we
recommend that doses not exceed 40
Mg-
I cant use minoxidil or Propecia so the mico benefits really excited me but the eye effects make me weary of further use. Thing is I kind of had some haziness before using mico, so maybe the nitrate is making it worse and not causing it. When I stop using it still remains but seemingly to a lesser degree.
ANYways, here is the link to the study. I have cut out two parts to get to the jist of whats going on.
http://archopht.ama-assn.org/cgi/reprint/100/9/1504.pdf
COMMENT
Fungal endophthalmitis is a serious
disease that usually destroys the eye.
Its treatment is often hindered
because only a few antifungal agents
are currently available, these agents
are toxic, and their ocular penetration
is extremely poor. In 1975, Jones5
reported the successful treatment of
Paecilomyces gougerotii dacryocysti-
tis with topical and IV miconazole,
and Aspergillus corneal ulcer with 1%
topical miconazole base in peanut oil.
This antifungal agent has also been
used for vaginal candidiasis6 and
extraocular Aspergillus infections.7
Intravitreous injection of antibiot¬
ics and closed vitrectomy have recent¬
ly been advocated for management of
endophthalmitis.9 Our goal in under¬
taking the experiments reported here¬
in was to determine whether micona¬
zole can be safely used as an intravit¬
reous injection or as an antimycotic
agent incorporated in the vitrectomy
infusion system during closed vitrec¬
tomy for fungal endophthalmitis. Our
results in rabbits show that both
miconazole nitrate and its vehicle
produce toxic damage to the retina
and crystalline lens in concentrations
of 100 Mg or greater, and that concen¬
trations ranging from 10 to 80 Mg
produce mild to moderate retinal
changes. However, the pattern of reti-
notoxicity appears somewhat irregu¬
lar, which may be due to variations in
the state of the vitreous gel among the
animals studied. We suspect that
formed vitreous may concentrate the
drug in a localized area of the vitreous
cavity and retina. Liquefied vitreous
may allow uniform dispersion of the
drug throughout the vitreous and ret¬
ina. This hypothesis may account for
the absence of retinal toxicity in doses
below 80 Mg in owl monkeys, which
normally have liquid vitreous. Retinal
delicacy or inherent susceptibility to
physical or chemical trauma may also
account for the marked differences
between the data collected in rabbits
and those obtained from monkeys.
The data in Table 6 reflect a widely
variable pattern of toxic retinal
changes at various drug dosage levels. Note, for example, while retinal changes developed in only one of four
eyes injected with 100 Mg of micona¬
zole nitrate (and these changes were
graded by our pathologist as "moder¬
ate"), histopathologic evidence of reti¬
nal damage developed in three of the
four eyes injected with only 20 Mg of
drug, and two of these three eyes
exhibited "severe" changes. We are
greatly encouraged by the fact that
clinically, electrophysiologically, and
histopathologically, miconazole ni¬
trate in doses up to 80 Mg appears to be
relatively well tolerated by the mon¬
key retina.
We are aware of only one report10
that described the use of 10 Mg of
miconazole nitrate for amphotericin
B- and flucytosine-resistant fungal
endophthalmitis caused by Paecilo-
myces lilacinus. The successful out¬
come of this case10 and our lack of
clinical, ERG, and histopathologic
evidence of retinal toxicity in owl
monkey eyes given less than 80 Mg of
miconazole nitrate justify the consid¬
eration of this antimycotic agent for
use in desperate cases of fungal
endophthalmitis. In such cases, we
recommend that doses not exceed 40
Mg-
