Creating Your Own Liposome Delivery Vehicle For Finasteride

[T Y]

This picture is what piqued my interest in dermal liposome delivery method
upon researching some more, I found this article below talking about transferosomes

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167026/#!po=11.5385

4.4. Ethanol injection method
In this process, the aqueous solution containing drug is heated with unremitting stirring at constant temperature. Ethanolic solution of phospholipids and EAs is injected into aqueous solution dropwise. As the solution comes into contact with aqueous media the lipid molecules are precipitated and form bilayered structures. This process offers assorted advantages over other methods, which include simplicity, reproducibility, and scale-up [54,55].

I also have an ultrasonicator to help break apart the liposomes if needed.

Ethanolic solution is comprised of 200 proof ethanol mixed with phospholipids. From my limited research, eggphosphatidylcholine (EPC) can be used it as a base.

https://www.sigmaaldrich.com/catalog/product/sigma/p3556?lang=en&region=US

This could be a method for delivering finasteride locally opposed to oral administration as a way to signficantly reduce side effects. The reasoning is, you'd need much less finasteride packed inside these phospholipids because they will be introduced into the cells transcellullary (because liposomes can fuse with cells) and intracellularly (because liposomes can break apart and release the drug locally; see ABC transporters). Vehicles such as DMSO will not permit transcellular absorption.

Liposomes are composed of biocompatible and biodegradable material, which makes it a safe way of drug delivery. If you are concerned, research more about lipid biology

I've already ordered my finasteride powder. I am thinking about microdosing it by packing them into these liposomes and dilute into a suitable solvent to apply dermally . I was a NW1.5 just couple weeks ago. Now I'm a NW2 as a result of taking creatine.
I am in the early phase of researching all this stuff. I encourage you to dig into the literature and share your findings as well!

 

[dogman]

I have H&W lipsomal finasteride, cost $50 and the bottles lasted me like a year..

 

[dogman]

Does it work and do you notice any side effects?

I get sides if I dermaroll and use it, otherwise no.

And not sure if it works, I'm a pretty stable NW2.5 so it's hard to tell

 

[Vinc2097]

I have H&W lipsomal finasteride, cost $50 and the bottles lasted me like a year..

i thought H & M were not making topical fina no more !? + when i emailed the it was like 120 $ per bottle per month..

50 $ a year for topical liposome fina ? hard to believe

 

[dogman]

i thought H & M were not making topical fina no more !? + when i emailed the it was like 120 $ per bottle per month..

50 $ a year for topical liposome fina ? hard to believe

In the EU Pharmacy I got it for $50 and it's lasted me about 8 months so far

 

[Vinc2097]

Can you post a link or send me a pm.

yeah me too haha !

 

[Ollie]

liposomal finasteride is pointless anyway. p-3074 showed that above 0.5ml of it and you start to inhibit the same amount as the 1mg pill. We all know for a full head of hair you need 5 ish mls

 

[T Y]

liposomal finasteride is pointless anyway. p-3074 showed that above 0.5ml of it and you start to inhibit the same amount as the 1mg pill. We all know for a full head of hair you need 5 ish mls

It seems p-3074 uses chitosan and chitosan derivatives as a hydrophilic vehicle for finasteride based on the patents.
What I'm proposing is the use of liposomes.

Two different things. Again, the shelf life for liposome is about a week and you start to lose efficacy. You might extend the shelf life by a couple weeks by packing your liposome with just the right amount of choleterol, specific sugars, etc. I don't have that magic formula because its not my field of research.

 

[Ollie]

It seems p-3074 uses chitosan and chitosan derivatives as a hydrophilic vehicle for finasteride based on the patents.
What I'm proposing is the use of liposomes.
View attachment 114934
Two different things. Again, the shelf life for liposome is about a week and you start to lose efficacy. You might extend the shelf life by a couple weeks by packing your liposome with just the right amount of choleterol, specific sugars, etc. I don't have that magic formula because its not my field of research.

My limited understanding is that Liposomes increase absorption, however the caveat being that you can get away with using much much less. However with finasteride with the dosage curve being so flat its difficult to avoid the systemic exposure.

On the topic of topical 5ar, you might be interested in this study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1132824/

It shows certain fats (primarily GLA) that inhibit 5ar hugely, and can remain localised.

 

[bluesuedeshoes]

i thought H & M were not making topical fina no more !? + when i emailed the it was like 120 $ per bottle per month..

50 $ a year for topical liposome fina ? hard to believe

I believe he meant 50 a bottle. I paid around 400 dollars for 6 bottles of 2.5% (they charge less if you go for a lower percentage) via the EU/Italian pharmacy. Obviously depends on how much you use but I would get through a bottle a month.

I have four bottles left right now but have opted to stop and rely on internal finasteride and brotzu. I tried the EU topical finasteride for a year and at various strengths. For me neither internal or external finasteride seems to have fixed my hairloss - I either have very aggressive male pattern baldness or AA just dont work for me.

 

[dogman]

Can you post a link or send me a pm.

The pharmacy was called Farmacia Parati, I got it dosed at 0.1% and use a small amount on my temples every 2 days and the 3rd day after dermarolling.

It might no do anything but I don't have erectile dysfunction and I've not lost ground (though its likely I have a stable NW2.5 anyway).

 

[Vinc2097]

I believe he meant 50 a bottle. I paid around 400 dollars for 6 bottles of 2.5% (they charge less if you go for a lower percentage) via the EU/Italian pharmacy. Obviously depends on how much you use but I would get through a bottle a month.

I have four bottles left right now but have opted to stop and rely on internal finasteride and brotzu. I tried the EU topical finasteride for a year and at various strengths. For me neither internal or external finasteride seems to have fixed my hairloss - I either have very aggressive male pattern baldness or AA just dont work for me.

even oral fina does nothing ?

 

[bluesuedeshoes]

even oral fina does nothing ?

Been on 1mg for about 8 months now and I have lost ground. Scalp is in perhaps slightly better condition but I still get the itch. Which I have major issues getting rid of.

 

[Vinc2097]

Been on 1mg for about 8 months now and I have lost ground. Scalp is in perhaps slightly better condition but I still get the itch. Which I have major issues getting rid of.

dam feels bad..