P&G and Curis
Won't be until 2007 or early 2008 until we see an IND from P&G
Until then we can only dream about.
Since it is well established that aberrant Hh pathway activity
in skin can lead to abnormal differentiation and various
follicular hyperplasias including BCC (Hahn et al, 1996;
Johnson et al, 1996; Dahmane et al, 1997; Oro et al, 1997;
Xie et al, 1998; Aszterbaum et al, 1999; Grachtchouk et al,
2000; Nilsson et al, 2000; Sheng et al, 2002), the effect of
Hh-agonist on differentiation in the skin was analyzed.
Seven-wk-old C57BL/6 male mice were either treated with
one topical dose of vehicle, Hh-agonist, or depilated to induce
anagen. Although hair follicles from vehicle-treated
skin were still in telogen 10 d after treatment (Fig 4A) both
depilated (Fig 4F) and Hh-agonist-treated hair follicles
(Fig 4K) were in anagen VI of the hair cycle. At this substage
of anagen, hair follicle size, proliferation, and hair
production are at their maximum.
The long-term effects of Hh-agonist treatment on proliferation
and differentiation in mouse skin were also examined.
Seven-wk-old mice were treated with either one
topical dose of vehicle or Hh-agonist to induce anagen.
Approximately 1 y later, skin from both groups was analyzed
by light microscopy and immunohistochemistry. Hair follicles
from both vehicle (Fig 5A)- and Hh-agonist (Fig 5B)-
treated skin were in telogen.
Paladini RD, Saleh J, Qian C, Xu GX, Rubin LL.
Modulation of hair growth with small molecule agonists of the hedgehog signaling pathway.
J Invest Dermatol. 2005 Oct;125(4):638-46.
PMID: 16185261 [PubMed - indexed for MEDLINE]
