different pathways of androgen signaling are involved in Androgenetic Alopecia, genomic factors which are mediated through the androgen receptor as well as non genomic effects that are in this case for example mediated by membrane androgen receptors(those will not be blocked by an anti androgen like RU or pyrilutamide for example)
furthermore this drug which itself does not have any sexual side effects because it is not an actual anti androgen, can amorqeliate BOTH, the genomic pathways by translocation of the androgen receptor in dermal papilla cells as well as non genomic pathways which seems to be induction of oxidative stress, by being a powerful ROS scavenger and thus reducing DHT induced mitochondrial dysfunction.
this might lead to a connection of androgenic alopecia and age related hair loss(which is usually not patterned). basically, androgens increase oxidative stress and inflammation which leads to cellular scenencense. this can be characterized as cells losing their original function and much like old people they become senile and dont work properly anymore, get damaged and die. there is various studies suggesting scenencense in dermal papilla cells of old people but also in bald scalp. basically DHT among other things make the hair follicle reach the phenotype of an old man much faster in young men leading to dysfunction.
there is a community effort at HairDAO, a community funding for hair loss (what I wish this forum would be basically)
(who got Ralf Paus on board) to synthesize this molecule and preperare it in a stable formulation (bc it tends to be unstable or stable only for a week or so). they actually funded their first study with dr Paus on thyroid hormones for Androgenetic Alopecia. I think this project is fantastic
check out their pipeline for funding:
www.hairdao.xyz
I think anyone can participate. there is no in vivo data on this drug however the in vitro data on cultured DP cells looks extremely promising and it scientifically makes a lot of sense
videos of Dr Paus and HairDAO. he said "hair loss is not a cosmetically disease, its not cosmetic if it affects people mentally", he seems to get it. personally I think most people here know a lot about hair loss so maybe it could be worth checking out this community and making a contribution to fund something like this and other projects
jbiomedsci.biomedcentral.com
