Cyproterone acetate+medroxyprogesterone for Male Hair Loss

[ledon]

After a couple of free consultations with various "hair clinics" I just forked out to see a qualified trichologist (probably about 2 years too late, but what can you do).

The end result of my 1.5 hr consultation was the suggestion that, as an alternative to propecia, I use a topical solution inhibiting the formation of DHT. The solution is made up of the following 2 anti-androgens often taken orally by female hair loss sufferers:

1.Cyproterone acetate
2.Medroxyprogesterone

This combination has been used, I've been told, with great success by both male and female hair loss sufferers over the last few years. There are obviously potential side effects for men with the potential of absorbtion into the system which, technically, could cause side effects similar to those caused by propecia. However in the trichologist's experience the benefits of this topical combination match those of propecia, the side effects occur far less often and certainly with less severity, and, although like with everything it will gradually lose effectiveness over time, it can be used indefinitely (unlike propecia usage which, apparently, cannot and should not be sustained over the very long term).

For the last three years the group to which this trichlogist belongs have been combining this solution with 3% minoxidil very successfully.

There is so much information out there about what works and what doesn't. I'm in london and have just paid a lot to hear the opinion of a well respected and very experienced trichlogist, but am feeling very cynical about what's been proposed to me.

If this stuff works surely we'd all be using it?

 

[hair_tomorrow]

I wonder if that stuff's available on-line anywhere. Time to google.

 

[ledon]

I've been looking - a lot!

Haven't found anything or anyone on the net suggesting that cyproterone acetate can be applied topically on male heads to counter male pattern baldness, however I do know that the belgravia centra of trichology website (a place in london whose opinions I didn't value) do combine 5% minoxidil with medroxyprogesterone - its mentioned on their website....

 

[Dice_Has_Hair]

Re: Cyproterone acetate+medroxyprogesterone for Male Hair Lo

After a couple of free consultations with various "hair clinics" I just forked out to see a qualified trichologist (probably about 2 years too late, but what can you do).

The end result of my 1.5 hr consultation was the suggestion that, as an alternative to propecia, I use a topical solution inhibiting the formation of DHT. The solution is made up of the following 2 anti-androgens often taken orally by female hair loss sufferers:

1.Cyproterone acetate
2.Medroxyprogesterone

This combination has been used, I've been told, with great success by both male and female hair loss sufferers over the last few years. There are obviously potential side effects for men with the potential of absorbtion into the system which, technically, could cause side effects similar to those caused by propecia. However in the trichologist's experience the benefits of this topical combination match those of propecia, the side effects occur far less often and certainly with less severity, and, although like with everything it will gradually lose effectiveness over time, it can be used indefinitely (unlike propecia usage which, apparently, cannot and should not be sustained over the very long term).

For the last three years the group to which this trichlogist belongs have been combining this solution with 3% minoxidil very successfully.

There is so much information out there about what works and what doesn't. I'm in london and have just paid a lot to hear the opinion of a well respected and very experienced trichlogist, but am feeling very cynical about what's been proposed to me.

If this stuff works surely we'd all be using it?

Another name for cyproterone acetate(CPA) is Androcur. GeminiX I believe takes it.........internally :freaked: :hairy:

 

[Dice_Has_Hair]

I just pm'd geminiX to see where he gets his Androcur. I'll let ya know what he says. :wink:

 

[Dice_Has_Hair]

You should ask him what he thinks about topical flutamide, whether or not he thinks that it would be worth a try. Ask him about topical spironolactone too, that is what I am using in my regimen. Ask him how one can make their own mix of this Cyproterone acetate and Medroxyprogesterone. This is interesting.

 

[GeminiX]

Be *very* careful with Androcur, it's nasty (Illegal in the US).

Very common side effects are depression, loss of libido and massive reduction in body hair.

It is often prescribed to sex offenders to kill their sex drive.

The upside is it is pretty much unbeatable in DHT blocking.

Do not even think of taking this without medical supevision, the effects are usually permanent, unlike finasteride.

D

 

[ledon]

I guess the issue with topical cyproterone acetate then is not whether or not it will block DHT, which I assume it does, but how much will actually get absorbed into the system causing adverse side effects.

As no-one here seems to have used it (topically) am guessing I'll just have to rely on the trichlogists advice, and ask what their experience of past and current users' side effects are..... The "non-reversible" bit is obviously a bit worrying, but then I've heard enough stories of people sufffering permanent effects after stopping propecia so who knows.

Will let you all know after the next meeting with the trichologist. In the mean time if anyone does have any experience of topically applying either cypr.acet or medroxyprogesterone, I'd really appreciate hearing about it.

Thanks.

 

[d_umberly]

I guess the issue with topical cyproterone acetate then is not whether or not it will block DHT, which I assume it does, but how much will actually get absorbed into the system causing adverse side effects.

As no-one here seems to have used it (topically) am guessing I'll just have to rely on the trichlogists advice, and ask what their experience of past and current users' side effects are..... The "non-reversible" bit is obviously a bit worrying, but then I've heard enough stories of people sufffering permanent effects after stopping propecia so who knows.

Will let you all know after the next meeting with the trichologist. In the mean time if anyone does have any experience of topically applying either cypr.acet or medroxyprogesterone, I'd really appreciate hearing about it.

Thanks.

Maybe you should read this from the inhouse pharmacy site, not available in the US cause this is some serious shite:

Important Note:
This medication should only be taken under specialist supervision. During treatment, liver function, adrenocortical function and the red blood-cell count should be checked regularly.

Androcur contains 50mg of cyproterone acetate, the most powerful anti-androgen yet developed. It inhibits the production of the male hormone testosterone, which is responsible for the development of male characteristics such as body hair, beard growth, deep voice, greasy skin/hair and the male sex drive.

What is Androcur commonly prescribed for?

In most countries Androcur (cyproterone acetate) can only been prescribed by a medical specialist.

Androcur or cyproterone acetate is an anti-androgen which is prescribed to treat androgen dependant conditions.

Cyproterone acetate is used for women who have too much androgen production and/or seem to be overly sensitive to androgen activity in their bodies. Cyproterone acetate is used for acne and/or overactive oil glands and hirsutism as well as androgen dependent hair loss.

In men, cyproterone acetate is used for prostate cancer treatment, to reduce sex drive in men, for the treatment of sexual aggression, and for use by male to female transsexuals in conjucntion with estrogen supplements.

What are the effects of taking Androcur?

Androcur is an antiandrogenic hormone preparation. It inhibits the influence of androgens which are also produced - to a slight extent- in the female organism, and also exerts a progestational and antigonadotrophic effect.

Cyproterone acetate inhibits competitively the effect of androgens at androgen-dependent target organs, e.g. it shields the prostate from the effect of androgens originating from the gonads and/or the adrenal cortex.

In the man, under treatment with ANDROCUR, sexual drive and potency are reduced and gonadal function is inhibited. These changes are reversible following discontinuation of the therapy.

In the woman, hirsuitism is reduced, but also androgen-dependent alopecia and elevated sebaceous gland function are reduced. During treatment, ovarian function is reduced.

Dosage:

The extreme range of dosage comes from input that some people find 10mg/wk sufficient to induce total impotence, and yet others take as much as 200mg/day with no obvious short-term adverse effects. Given this range, it would seem prudent to start on the low side and work your way up only if necessary. More than 100mg/day is generally considered excessive.

There are some reports of depression when the dosage is too high for a given individual. There appears to be a causal relationship because the depression evidently disappeared as soon as the dosage was reduced, according to those reports.

WARNING:

Androcur is the most powerful of anti-androgen drugs and must not be taken by any patient with a medical condition, or one who is taking / has recently taken other drugs that are contra-indicated.

During treatment, liver function, adrenocortical function and the red blood-cell count should be checked regularly.

Direct hepatic toxicity, including jaundice, hepatitis and hepatic failure, which has been fatal in some cases, has been reported in patients treated with 200 - 300mg cyproterone acetate. Most reported cases are in men with prostatic cancer. Toxicity is dose-related and develops, usually, several months after treatment has begun. Liver function tests should be performed pre-treatment and whenever any symptoms or signs suggestive of hepatotoxicity occur. If hepatotoxicity is confirmed, cyproterone acetate should normally be withdrawn, unless the hepatotoxicity can be explained by another cause, e.g. metastatic disease, in which case cyproterone acetate should be continued only if the perceived benefit outweighs the risk.

 

[Vega]

as geminix says be very very careful with androcur.

if you take Androcur you will probably lose the ability to have children within 6 months, and that is permanent. Also even more worryingly proir to this your sperm become damaged so you could end up with a similarly damaged child. You cannot take androcur AND have children

It is not a drug designed to be gentle with the male reproductive system like finesteride is, and it is primarily used in treatment of prostate cancer, albeit in higher than normal doses (upwards of 200mg day). However its become the latest anti androgen for transsexual male to females to nulify the effects of testosterone with good effects (general dosage for transexual is between 50 and 100mg daily).

Androcur also has links with liver failure and liver disease and therefore anyone taking it must have a liver function blood test once every three months.

it is also not available easily, although you can buy it on inhouse pharmacy. they buy it in Vanutu in the pacific. Generally it is only prescribed to persuasive transsexuals and males with prostate problems

its possible that it can help with male pattern baldness but there is not sufficient research done into this. It is a drug that has been used to treat female hair loss for a while.

 

[Petchsky]

Sounds like some heavy duty sh*t.

You got any new pics yet Gemini?

 

[d_umberly]

Sounds like some heavy duty sh*t.

You got any new pics yet Gemini?

Petchsky,

For most I think this is approriate only a last ditch effort to stay alive. I wouldn't want to have people at my funeral commenting on my nice hair and big tits. :freaked2:

 

[ledon]

I think it's important that i stress that, as I'm neither a woman nor wanting to become one, taking androcur is not on my list of potential hair remedies!

However, applying TOPICAL cyproterone acetate, as I said in my first post, has apparently been very successful when combined with medroxyprogesterone in slowing down and stabilizing hair loss. I read the information pamphlet thing that was given to me by the trichologist again - the stuff they provide is made up of 0.004 mg of Cyproterone acetate and Medroxyprogesterone.

That amount, apparently, is sufficient when applied topically to inhibit the effects of DHT without causing side effects. I questioned this with the trichologist, saying that if there's enough there to slow down hair loss, there's probably enough there to inhibit sex drive/grow tits etc. The trichologist said that all she could respond with is her experience of clients using this over the last 7 years - good mainentance (in the majority of cases also changing vellus hairs in the affected areas into terminal hairs) and little to no side effects.

To be honest I've researched this stuff as much as I can - time to either believe the expensive and experienced trichologist lady and have a bash or assume she's talking cack like 99% of "snake oil" salesmen out there.

The one main thing in her favour is that while my initial consultation with her was expensive, the treatment itself and any subsequent consultations I have with her are relatively inexpensive, so she has very little to gain by screwing me over with something that won't work/will make things worse (especially as I've gone to great lengths to let her know that she's going to be personally accountable to me, as far as I'm concerned, if I turn into a woman overnight!).

Am thinking I should go with it.

Again, anyone who's had any experience of topically applying either of these substances please let me know (before it's too late!!)

 

[Vega]

ive never heard of topical cyproterone acetate, and im no doctor but im told androcur works by curbing receptors in the brain that tell the body to make testosterone - so its not gonna stop any side effects no matter where you apply it - also its not like minoxdil which acts directly on the follicle - at least i think thats the case i might be wrong. If you take androcur long enough your testies begin to shut down through lack of action, and they dont recover

 

[Juneworldcup]

Howdy - I am a 44 year old female and due to stressful situations, I started losing hair profusely in the last 12 months. After several doctors and specialists, I am now trying Philip Kingsley and started this topical treatment 10 days ago. So far, it has been working miracles for me! My hair loss has gone done from 200-300 a day to 50-100 and my hair are looking much thicker. Also the itching I felt on my scalp has subsided.

My question to those who tried it -
1. has this benefit continued for you over the years or did the hair loss come back after a few years?
2. Was there anything you did that worked on eliminating the root cause (as in hormone imbalance in women that reduced estrogen+ progesterone and increases free testosterone in the body)?

Many thanks and a happy 2019 y’all!!