Cytomedix - AutoloGelâ„¢ System (16 Jul 08)

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chrome

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CYTOMEDIX CEO ISSUES SHAREHOLDER UPDATE - 16 Jul 08
http://www.cytomedix.com/pressreleases/Jul16_08.htm

1st product - allows individualized patient care and an effective alternative for managing difficult chronic wounds.

We officially launched the AutoloGelâ„¢ System in the first quarter of this year

Cytomedix maintains an intellectual property portfolio of seven U.S. Patents, and comparable international patents, covering a range of advanced tissue regeneration technologies, including wound care, angiogenesis, hair growth and anti-inflammatory therapies.

As I mentioned earlier, there are other potential applications for our AutoloGelâ„¢ technology including hair growth or transplantation, application in combination with other wound care products, and application or delivery of cellular therapeutic products including stem cells. We are actively seeking strategic partnerships and/or licensing opportunities for many of these uses.

We are continuing to pursue additional reimbursement pathways, including Medicare, and to exploit other applications and strategic alliances for AutoloGelâ„¢ such as hair transplantation.

At the same time, we are developing new important peptides from within our patent portfolio, which offer the potential for a fresh approach to angiogenesis, and address the multi-billion dollar anti-inflammatory therapeutic markets.
 
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chrome

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July 16, 2008 - Cytomedix maintains an intellectual property portfolio of seven U.S. Patents, and comparable international patents, covering a range of advanced tissue regeneration technologies, including wound care, angiogenesis, hair growth and anti-inflammatory therapies.

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Both Patents are IDENTICAL:

Method for promoting hair growth. US Patent 4,957,742 - 18.09.90
http://patft.uspto.gov/netacgi/nph-...4,957,742.PN.&OS=PN/4,957,742&RS=PN/4,957,742

Method for promoting hair growth . US Patent 5,178,883 - 12.01.93.
http://patft.uspto.gov/netacgi/nph-...5,178,883.PN.&OS=PN/5,178,883&RS=PN/5,178,883

Abstract
Platelet enriched plasma is produced from blood. The platelets are activated by thrombine which causes therelease of platelet-derived growth and angiogenesis factors. A carrier such as a microcrystalline collagen is added to produce a wound-treating salve. The composition is applied directly to wounds and initiates healing in nonhealing wounds as well as accelerating normal wound-healing by increasing vascularization, stimulating fibroblast mitrosis and migration, and increasing collagen synthesis by fibroblasts. The composition is also applied to tissue to facilitate the growth of hair.

Topical application of the compositions to areas of tissue containing hair follicles has also been found to promote hair growth where no growth or limited growth was previously observed.

EXAMPLE IV
A diabetic patient who had received a renal transplant and had had a below the knee amputation ("BKA") was treated with a composition prepared as described above. The composition was applied to the patient's stump, including a portion of tissue containing hair follicles, for a period of approximately 31/2 months. After treatment, significant hair growth was observed in the area of treatment with the composition where no hair had previously been observed.

EXAMPLE V

Four patients were treated with a composition prepared as described above, with the exception that the platelet buffer used did not contain human serum albumin.

In all four patients, after treatment, significant hair growth was observed in the area of treatment with the composition where NO hair had previously been observed.

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Angiogenic peptides . US Patent 5,470,831 - 28.11.95
http://patft.uspto.gov/netacgi/nph-...5,470,831.PN.&OS=PN/5,470,831&RS=PN/5,470,831

Selecting amounts of platelet releasate for efficacious treatment of tissue . US Patent 5,599,558 - 04.02.97
http://patft.uspto.gov/netacgi/nph-...5,599,558.PN.&OS=PN/5,599,558&RS=PN/5,599,558

Anti-inflammatory peptides . US Patent 5,776,892 - 07.07.98
http://patft.uspto.gov/netacgi/nph-...5,776,892.PN.&OS=PN/5,776,892&RS=PN/5,776,892

Enriched platelet wound healant . US Patent 6,303,112 - 16.10.01
http://patft.uspto.gov/netacgi/nph-...6,303,112.PN.&OS=PN/6,303,112&RS=PN/6,303,112

Enriched platelet wound healant . US Patent 6,524,568 - 25.02.03
http://patft.uspto.gov/netacgi/nph-...6,524,568.PN.&OS=PN/6,524,568&RS=PN/6,524,568
 
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chrome

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What i found interesting is that, because the Patents are old, they have researched this product for nearly 20 years and have recently received FDA marketing clearance for its AutoloGelâ„¢ System for wound treatment (Sep 2007 - http://www.fda.gov/cber/seltr/k060007L.htm) and have ALREADY officially launched the AutoloGelâ„¢ System in the first quarter of this year, 2008.

It also ticks many of the right boxes , it treats hairloss, inflammation, heals wounds & is angiogenic - all classic hairloss treatments.

Some of those appear patents show excellent results for wound healing & inflammation. The science appears to be quite good/strong.

Although it is initially being sold to treat wounds, it would be nice if this treatment were available "off-label" to apply topically to the scalp, as the Patent quite clearly says it can - and with very good results, including significant growth of hair where there was no hair before.

Even if thats not possible, atleast its another promising avenue of research Cytomedix have already stated they "are actively seeking strategic partnerships and/or licensing opportunities for many of these uses. (including hairloss)" - so we appear to have another treatment option on the table.

The more the better imho.
 
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chrome

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and i'll bet you think you'll get Berbatov for £20m as well :punk:


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C

chrome

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clearly not that interesting.

its a sad day when utter bollox like "Revivogen vs. Crinagen", "hairmax" & "minoxidil" gets more interest than a potentially revolutionary new topical.

its no wonder i gave up posting on these forums as i'm fed up of all the useless treatments ,that do absolutely jack-sh*t, being talked about ad nauseum.

perhaps i should begin a "Does masturbation cause hairloss ?" thread .

How very sad.

still, c'est la vie & au revoir.
 
DoctorHouse

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Hey, Chrome how are you doing? Did you ever recover from your huge shed on Promox?
 
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rusty_y2k2

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It is indeed interesting - thanks for the post chrome... I look forward to hearing more about these types of treatments over the next few years.
 
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chrome said:
clearly not that interesting.

its a sad day when utter bollox like "Revivogen vs. Crinagen", "hairmax" & "minoxidil" gets more interest than a potentially revolutionary new topical.

its no wonder i gave up posting on these forums as i'm fed up of all the useless treatments ,that do absolutely jack-s***, being talked about ad nauseum.

perhaps i should begin a "Does masturbation cause hairloss ?" thread .

How very sad.

still, c'est la vie & au revoir.
Click to expand...

hahaha :).

BTW would be very interesting to try. Is it the same blood treatment we saw like year ago? I remember seeing pictures.
 
hairsucks

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Chrome is right, Anyone mentions an alternative/experimental/new treatment other then the big 3 on this and other forums and it gets shot down, all you see is:

Sales man, snake oil (Davidoff’s favorite quote), Spam,

It stops the more interesting posters (like Chrome) from posting anymore. I think if I found an alternative that works for me I wouldn't even tell people on here because I would expect :spam: as a response.
 
chore boy

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Chrome,

From the looks of it, it appears that it's a system that a physician would have to buy and then extract your platelets, adjust them to a certain concentration and add them to a carrier, then apply it to the individual patient. Is that pretty much the jist of it?
 
chore boy

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I wonder if this could be done off-site?
 
chore boy

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I don't think I've heard of PDGF before...

PDGF isoforms induce and maintain anagen phase of murine hair follicles

Background : It is known that platelet-derived growth factor (PDGF) receptors are expressed in hair follicle (HF) epithelium. Objectives : The aim of the present study was to clarify the effects of PDGF-AA and -BB on the cyclic growth of HFs. Methods : PDGF-AA or -BB was injected into the dorsal skin of C3H mice during the second telogen phase once daily for five consecutive days, or PDGF-AA or -BB dissolved in hyaluronic acid was injected only once. In order to confirm the effects of different PDGF isoforms, anti-PDGF-AA antibody or anti-PDGF-BB antibody was injected just after each injection of PDGF-AA or -BB. In addition, anti-PDGF antibodies were injected into the skin of C3H mice during the second anagen phase once daily for 5 days. We studied expression of signaling molecules in the skin where anagen phase had been induced by PDGF injection by real-time RT-PCR. Results : Both PDGF-AA and -BB injection experiments immediately induced the anagen phase of the hair growth cycle at the injection sites. The induction of anagen was interfered by anti-PDGF antibody treatment. Real-time RT-PCR using extracted RNA from the PDGF injected sites of skin samples showed upregulated expression of HF differentiation-related key signaling molecules, Sonic hedgehog (Shh), Lef-1 and Wnt5a. Conclusions : These results indicate that both PDGF-AA and -BB are involved in the induction and maintenance of the anagen phase in the mouse hair cycle. Local application of PDGF-AA and -BB might therefore prove to be an effective treatment option for alopecia associated with early catagen induction and elongated telogen phase.
 
patagonia

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Great info Chrome & Chore boy.

I agree with hairsucks... this is called ¨EXPERIMENTAL TREATMENTS¨ for a reason...
this section should be all about trying new and different things and sharing info.

:)
 
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EXAMPLE IV
A diabetic patient who had received a renal transplant and had had a below the knee amputation ("BKA") was treated with a composition prepared as described above. The composition was applied to the patient's stump, including a portion of tissue containing hair follicles, for a period of approximately 31/2 months. After treatment, significant hair growth was observed in the area of treatment with the composition where no hair had previously been observed.
Click to expand...

Let me get this straight. They grew hair where there was never hair in the first place. Jesus christ that's awesome.
 
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