Does anyone have a copy of this study,
http://www.ncbi.nlm.nih.gov/m/pubmed/25627907/?i=7&from=alopecia
http://www.ncbi.nlm.nih.gov/m/pubmed/25627907/?i=7&from=alopecia
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Dermatosis of the scalp following Latanprost application for Androgenic Alopecia
- Thread starter shivers20
- Start date
Title: Erosive pustular dermatosis of the scalp following topical latanoprost for androgenetic alopecia Author list VACCARO, M. (1) Barbuzza, O. (2), Francesco, B. (1), Serafinella, C. (1) (1)University of Messina, Department of Clinical and Experimental Medicine, - Dermatology, Messina, Italy, (2)University of Messina, Allergist, Private Practice, Messina, Italy Introduction & Objectives Erosive pustular dermatosis of the scalp is an inflammatory chronic disease, with extensive pustular lesions, erosions and crusting of the scalp of elderly individuals, leading to scarring alopecia.
A local trauma is often described as a trigger factor on actinically damaged or otherwise atrophic skin as well as associations with autoimmune disorders. Material & Methods We present a 61-year-old woman with a history of eroded, pustular and crusted lesions, confined to the scalp, developed after the application of latanoprost 0.1% ternary solution (50% ethanol, 20% propylene glycol, water) for the treatment of mild frontotemporal androgenetic alopecia. Results Physical examination revealed pustules, erosions, scales limited to the site of application of latanoprost 0.1% solution. Detachment of the crust revealed a moist, atrophic surface with prominent teleangiectases, erosions and superficial pustulation . Histology was nonspecific, periodic-acid-Schiff stain and direct immunofluorescence were negative. Repeated bacteriologic and mycologic investigations were negative. The clinical and histopathological features were consistent with a diagnosis of EPDS. Application of the drug was immediately stopped and the patient was treated with oral methylprednisolone (16 mg/day with progressive reduction), oral zinc sulphate (200 mg/day) and a 0.05% clobetasol propionate foam. After 6 weeks, resolution with residual scarring alopecia was observed. Conclusions The case presented here is of interest because, although trauma has been documented to precipitate this condition, to the best of our knowledge topical latanaprost, a prostaglandin analogue recently used to stimulate eyelash growth in alopecia areata and hair growth in androgenetic alopecia , has not previously been reported as a triggering factor. In fact, none of the previous reported side effects of latanoprost included chronic pustules, scale crusts and non-healing erosions.
A local trauma is often described as a trigger factor on actinically damaged or otherwise atrophic skin as well as associations with autoimmune disorders. Material & Methods We present a 61-year-old woman with a history of eroded, pustular and crusted lesions, confined to the scalp, developed after the application of latanoprost 0.1% ternary solution (50% ethanol, 20% propylene glycol, water) for the treatment of mild frontotemporal androgenetic alopecia. Results Physical examination revealed pustules, erosions, scales limited to the site of application of latanoprost 0.1% solution. Detachment of the crust revealed a moist, atrophic surface with prominent teleangiectases, erosions and superficial pustulation . Histology was nonspecific, periodic-acid-Schiff stain and direct immunofluorescence were negative. Repeated bacteriologic and mycologic investigations were negative. The clinical and histopathological features were consistent with a diagnosis of EPDS. Application of the drug was immediately stopped and the patient was treated with oral methylprednisolone (16 mg/day with progressive reduction), oral zinc sulphate (200 mg/day) and a 0.05% clobetasol propionate foam. After 6 weeks, resolution with residual scarring alopecia was observed. Conclusions The case presented here is of interest because, although trauma has been documented to precipitate this condition, to the best of our knowledge topical latanaprost, a prostaglandin analogue recently used to stimulate eyelash growth in alopecia areata and hair growth in androgenetic alopecia , has not previously been reported as a triggering factor. In fact, none of the previous reported side effects of latanoprost included chronic pustules, scale crusts and non-healing erosions.