Dissociated Skin Cells Regenerate Hair Follicles In A Microwound, "the Punch Assay".

[dermrafok]

Dissociated Skin Cells Regenerate Hair Follicles in a MicroWound, "The Punch Assay".

Abstract
The purpose of this study was to develop a new, easily executed hair follicle regeneration system and assay, which could be further developed for clinical or cosmetic applications. Dissociated epidermal and dermal progenitor cells, isolated either from neonatal C57BL/6 mice or human fetal scalp tissues, were suspended in (10μl) F12 medium and pipetted into a 1or 2 mm-diameter punch biopsy wounds on the back skin of immunodeficient mice. At 3 weeks after transplantation, although pigmented mouse hairs could efficiently form at the injection sites with delivery of mouse cells, none hair formed on the host mouse skin at 3 months after delivery of human cells. Under the same conditions, human follicles could be regenerated when the human skin cells were delivered onto a 2 mm-size punch created on a reconstituted human skin (hRSK), which previously generated on the back of an immunodeficient mouse, but the efficiency of hair formation was low. We demonstrated that both mouse and human regenerated follicles showed normal histology and differentiation markers, moreover the cell chasing experiment confirmed that the regenerated hair follicles were formed from transplanted cells. Compared to other current hairreconstituted assays, the punch assay is relatively simple and generates normal hair follicles within a smaller wound. We suggest that the punch assay is a better in vivo assay of cell trichogenicity.


https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.13753

 

[Spanishboy97]

Promising, but where do you get a large supply of “neonatal fetal scalp tissue” from which to harvest the necessary cells? Abortions? No thanks. - I’d rather be bald than walk around with a head full of hair generated by butched babies.

If it gives me hair I don't give a single f*** to be honest

 

[DanielDüsentrieb]

Promising, but where do you get a large supply of “neonatal fetal scalp tissue” from which to harvest the necessary cells? Abortions? No thanks. - I’d rather be bald than walk around with a head full of hair generated by butched babies.

If it gives me hair I don't give a single f*** to be honest

I think it suits the topic....

 

[Spanishboy97]

Despite what you think of abortion, I’m curious how far you’d willingly go to get a full head of hair. For example, if I told you 10/10 full head of hair was yours if you just murdered someone, and I could promise no consequences for your actions (ie, no one will know you did it, you won’t go to jail, etc.), would you? If that’s too extreme for you, how about just crippling someone? Still too extreme? How about an amputation? Or, the least of all, just switching places with someone who had a full head of hair, so that they instantly became an Norwood-whatever-you-are, and you get their hair?

I guess I’m just curious how cruel and inequitable you’re willling to be to get a full head of hair.

Well if you are going to go down that road I don't know why you start with "despite what you think of abortion" given that is what ethically consurance you about this stuff. I don't have a strong opinion about the abortion issue, but if they gonna do it anyway and there is a medical benefit for other people I do not see a problem about using it

 

[Spanishboy97]

By the way, I remember you were the guy that said some months ago that "all rational people should have, on some level, problems with races that are not white or asian", you have some curious moral standars in my opinion.

 

[BaldAsshole]

Despite what you think of abortion, I’m curious how far you’d willingly go to get a full head of hair. For example, if I told you 10/10 full head of hair was yours if you just murdered someone, and I could promise no consequences for your actions (ie, no one will know you did it, you won’t go to jail, etc.), would you? If that’s too extreme for you, how about just crippling someone? Still too extreme? How about an amputation? Or, the least of all, just switching places with someone who had a full head of hair, so that they instantly became an Norwood-whatever-you-are, and you get their hair?

I guess I’m just curious how cruel and inequitable you’re willling to be to get a full head of hair.

No consequences? I would kill every one of you.

 

[BaldAsshole]

By the way, I remember you were the guy that said some months ago that "all rational people should have, on some level, problems with races that are not white or asian", you have some curious moral standars in my opinion.

I agree with the racial issue, aunque también es verdad que para muchos estadounidenses los españoles no somos blancos ni por asomo.

 

[Spanishboy97]

I agree with the racial issue, aunque también es verdad que para muchos estadounidenses los españoles no somos blancos ni por asomo.

Hahaha certainly, when I grow a beard Iook like an arab

 

[Soundwave]

My opinion on race has absolutely nothing to do with "moral standards," and everything to do with reality, empirical data, and reason. The formal is subjective, the later is objective.



Define "españoles" - anyone conquered by Spain in South, Central, and Northern America? They aren't - they're mestizos. Even a lot of Spaniards have significantly higher levels of North African genetic admixture than the rest of Europe.



And I'm not judging you for it, I'm just curious how far people would willingly go vis-a-vis another's suffering.

Anyway, you can keep the murdered baby hair - I'll wait for something a little less gruesome.

No problems with slanting anyone with dark skin, but the buck stops at cute fetuses I suppose (presumably only white and Asian ones though).

 

[BaldAsshole]

My opinion on race has absolutely nothing to do with "moral standards," and everything to do with reality, empirical data, and reason. The formal is subjective, the later is objective.



Define "españoles" - anyone conquered by Spain in South, Central, and Northern America? They aren't - they're mestizos. Even a lot of Spaniards have significantly higher levels of North African genetic admixture than the rest of Europe.



And I'm not judging you for it, I'm just curious how far people would willingly go vis-a-vis another's suffering.

Anyway, you can keep the murdered baby hair - I'll wait for something a little less gruesome.

I mean Spaniards. It is not true that we mixed that much with africans.

You may have all the problems that you want with Spaniards, the hell if I care, but we have lower criminality rates than the USA, France, UK, Sweden, South Korea, Denmark, Finland....

United States of America 5.35

France 1.23

United Kingdom 1.20

South Korea 0.70

Denmark 0.98

Finland 1.42

Germany 0.88

Spain 0.69

Most of our criminality (75% in 2008, it is illegal to say it anymore, but everyone believes that the percentage has raised since then) is committed by immigrants, by the way.

 

[Armando Jose]

Define "españoles" - anyone conquered by Spain in South, Central, and Northern America? They aren't - they're mestizos. Even a lot of Spaniards have significantly higher levels of North African genetic admixture than the rest of Europe.

No los asturianos

Not in Asturias

 

[Spanishboy97]

My opinion on race has absolutely nothing to do with "moral standards," and everything to do with reality, empirical data, and reason. The formal is subjective, the later is objective.
Well the problem with the thing you asked me about abortion is that you took for granted that abortion is supported by people so horrible that only terrible peopñe would do (you asked me how many people i would kill after the abortion thing) and you know, abortion is a complicated issue, not only for terrible people


Define "españoles" - anyone conquered by Spain in South, Central, and Northern America? They aren't - they're mestizos. Even a lot of Spaniards have significantly higher levels of North African genetic admixture than the rest of Europe.



And I'm not judging you for it, I'm just curious how far people would willingly go vis-a-vis another's suffering.

Anyway, you can keep the murdered baby hair - I'll wait for something a little less gruesome.

 

[Spanishboy97]

What problem would there be with stating empirical, objective data on the one hand and not wanting to murder babies on the other? If you think the two are morally equivalent, you’ve got a pretty sociopathic, nihilistic world view. And you also say having an objective problem with someone that isn't white or asian is something empirical, well I do not understand that way of thinking given that every individual deserves all my respect given that he is human, no matter the race. I am not trying to insult you or anythint I think you are a very valuable person to the forum, a smart guy, but I do think that you should be more consider with these kind of delicate issues




I have absolutely no problems with Spaniards, and of course you have lower crime levels than the US - what first world country doesn’t? The difference is it’s not illegal in the US (yet) to say why, and the reason is that the US has had about 300 years of “immigrant” problems, while Spain has only had a decade or two. Give your country another century or so of unchecked illegal immigration from sub-Saharan and North Africa, then see where your crime rates go.

Anyway, this is hair blog, not a political one, so I’ll stop threadjacking.

Sorry for the previous missquote before I was drunk, the problem is that you immediately compare someone who doesnt criminalize abortion (such as myself) with someone that would be ok with killing people, when abortion is a very complicated issue and you probably know that.

 

[LosingHairLosingPatience]

The moment you allow the harvesting of aborted fetuses is the moment killing babies becomes a for profit business. This is not rocket science.

There is no "kind of" killing something. You either kill it or you dont.
If anyone here is on the fence on the issue, search online and watch one being performed.

 

[coolio]

There is no "kind of" killing something. You either kill it or you dont.
If anyone here is on the fence on the issue, search online and watch one being performed.

Early and late abortions are very different situations.

And anyone who protests legal abortion, without supporting cheap/free access to birth control just as loudly, is an irrational punitive a**h**.

 

[furrydome]

Man, I come here for the hair, not for stuff that pisses people off. You can get that stuff, well, everywhere else.

 

[kiwi666]

Promising, but where do you get a large supply of “neonatal fetal scalp tissue” from which to harvest the necessary cells? Abortions? No thanks. - I’d rather be bald than walk around with a head full of hair generated by butched babies.

I’d rather you be bald too.

Me though? Well I’m an atheist with zero scruples when it comes to Christian ‘fairytales’ getting in the way of ‘scienctific’ progress.

 

[kiwi666]

Not really. I'm not religious; on my best day, I'm agnostic. My position against abortion is founded in a profound belief in basic human rights, the fundamental of which is the right to life. There is no consensus as to when the spark of life ignites. Given we don't know the exact moment life begins, performing abortive procedures that potentially could take place AFTER that moment would result in murder, and as murder is not only immoral but also irreversible, I think we should err on the side of caution and not perform abortive procedures that may result in murder. I am similarly against the death penalty; innocent people are, on occasion, executed, and since the legal system isn't infallible, and executions aren't reversible, we shouldn't be metering out punishments that could potentially result in the murder of an innocent person. That's just the philosophical/practical reason I'm against abortion. You could also make a biological one, but it's more subjective. To wit, I think there's a good argument to be made that life can be defined - fundamentally - as a sustained metabolic process, which is to say, the ability to grow and/or maintain homeostasis. If that's the case, then life begins the second we're concieved, and ends the moment are bodies are no longer able to metabolize. If this is the case, then whether you interrupt that metabolic process at day 0 or day 30,000, if you do it unjustly (and I can't think of anything more unjust than killing a baby), you've committed murder.

Since we're on the subject, and as this is the last post I'll make about it (I promise), I'll ask the Americans on this site who are curious about this issue to read the cases that culminated in Roe v Wade. The decisions that shaped our abortion laws are totally nonsensical and have no basis in law or science. For example, the trimester framework which so rigidly controls when and when you can't abort a child isn't a scientific concept - Blackmun just made it up based on some research he did over a weekend while writing the decision. Roe was and remains a political compromise, and was not nor was it ever intended to be a dialectic on the morality of abortion.

But yeah, I'm all for sex education and free birth control.

Bro you should cry your guilt river somewhere else. I’m sure there is a moral high ground forum somewhere else.

Oh and Forget about sex education! We need those fetuses!!!!

 

[Noobie]

Awesome, well-reasoned rebuttal, "bro."

Note, unlike you, I'm not going to downvote you, because downvoting is for triggered faggots.

Nice a racist and homophobe! Ban this triggered white boy.

 

[BaldAsshole]

The guy has sustained his points, one could agree or not with him, but there is no reason to ban him, at least for what I have read.