Several people have claimed that setipiprant gave them full maintenance without the need for any anti-androgens involved. What is your opinion on this? Does anyone here use Seti with or without an AA? What has your experience been? I’m very interested in high dose oral seti for complete maintenance as there are little to no sides, especially sexual ones. Thanks for any information provided.
Does Setipiprant Need To Be Used With An Anti-androgen?
- Thread starter strandman
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The so-called theory on setipiprant is that it works downstream of anti-androgens, and can thus replace anti-androgens.
It will stop further damage to your hair. However, it will give you marginal or no regrowth.
At this time, none of this is demonstrated. We should know by the end of the year, if phase II trial results are released.
What do you think about online anecdotal reports from Seti users? Most who are using it claim that 2g/day orally is very effective in maintaining all current hair. Has there been any major progress in the clinical trials? I don’t know much about the process but I assume that the fact that it made it from Phase I to II is a very good sign.
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It's hard to judge, as a lot of the people using seti are throwing the kitchen sink at their hair.
What I trusted when I perused reports a while back, is that it may definitely reduce itch, and/or cause insomnia.
I had to abandon all treatments (finasteride, ru58841) because of severe side effects that have yet to subside. I was scared to death, and continu By minoxidil while adding Seti was my only choice. I have been pleasantly surprised. The maintenance, in my experience, is legit. I had about three weeks of tough sleeping, and then it evened out.
That’s awesome man, what dose of seti are you taking? Topical or oral? Also, how long were you on finasteride/RU, and how long has it been since you quit? Which persistent sides are you feeling? I ask most anti-androgen users this stuff cause I’m keeping a log of anecdotal reports on AAs. Thanks for the response.
Taking 800mg two times a day. So, 1.6g total per day. Orally. Took finasteride for 13 years. Had a severe crash (adrenal, brain fog) five years ago that I never attributed to finasteride. Only ever thought finasteride caused sexual sides, which I hadn’t gotten to that point. Thought that people that complained about finasteride being dangerous etc were just THINKING they were experiencing side effects. Switched to a topical finasteride two years ago. All brain fog went away. Like an idiot, this fall, I decided to go back on the pill and see if I could gain some ground. Within two weeks, my penis was dead, libido non-existent, brain fog back. Quit immediately, still have not returned to normal. Until it bites you, you always think the people complaining of sides are crazy. I’m sure there’s some who are, but the fallout from finasteride, when it gets you, is real.
Thanks for sharing your experience. I’ve been on finasteride for two months, but I quit a few days ago because I felt my libido getting lower. I’m hoping I don’t experience any sort of post finasteride crash.
If I were you, I would ween off. Slowly decrease the doses. Don’t just stop cold turkey.
I took .25 for 2 days then .1 for 2 days then stopped yesterday. I know it’s not much of a wean but I really did not want to take it anymore. I’m confident that because I was only on it for two months and barely experienced any side effects in that period, that I won’t crash. I purchased a month’s supply of Clomid and Tamoxifen just in case. Do you still think I should get back on and slowly wean instead, maybe 0.1mg per day for awhile?
No, for such a short duration, I would say you’re good. I wish I had weaned off the second time. Foolish on my behalf. Even just for two weeks of taking it. I think that’s why avoided effects the first time. Anyway, seti has been great.
Have you tried any supplements or medications to recover from your crash? Clomid and Tamoxifen sound like the best pharmaceuticals for it, as the post finasteride crash has all the hallmarks of a steroid user’s endrocrine crash after stopping steroids.
Edit: And you weaned off the first time on finasteride? How long did you wean for?
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Really , what about the study of cetirizine done in 2017 ?
Why Setipiprant is recluiting for phase 3 ?
Did you even bother to read the study done on 2012 about PDG2 ? PDG2 is the only elevated molecule on the balding scalp, no DHT . And Porstaglandines are always the cause of something, never the consequence .
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Are you a shareholder or something?
It's not that complicated. Setipiprant is currently being tested (at very high dosages that are beyond most people's price range) and we'll learn of the results later this year. We'll see how well it does on its own over a 24-week period. We'll see how well it regrows hair, and what the side effect profile is. There are some posters who have tried setipiprant and reported null results, which suggests that it won't work for everybody.
Cetirizine is a different molecule. It has a different amplitude of effect, a different mode of action(s), it has other effects as well, and a different level of systemic penetration. The study on cetirizine was also one where the treatment was a topical one, rather than a pharmaceutical. The study also reported no side effects, which is wonderful if it holds up. In contrast, setipiprant will almost certainly affect mood and personality, as PGD2 plays a significant role in the brain.
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PGD2 is not the only molecule elevated in the scalps of balding men, nor is it the case of prostaglandins are never the consequence of other developments, don't post pseudoscience. For example, it's well-known that balding scalps contain more androgen receptors:
https://www.ncbi.nlm.nih.gov/pubmed/9496234
Balding men don't have more DHT -- that's well known. Some studies suggest that they might even have less DHT. What they do have is a different sensitivity to DHT. The higher rates of heart disease and prostate cancer suggest that the androgen receptors may be disproportionate elsewhere in the body as well.
mowingdown
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Well said. Same thing happened to me. I noticed some libido issues which is where I drew the line before I initially started finasteride (libido + brain fog were a no go for me). Within 3 weeks it was a hard crash and it took almost a full year to get back to baseline. Keep chugging along, workout, make sure you're getting plenty of water, and you will get there!
What type of Seti are you using? I bought some Lyphar, but have seen some complaints on here about brain fog which is another compromise I'm not willing to make. Thanks in advance!
How long were you on finasteride for? And you crashed after quitting or while still on it?
I’m using Zhe Chems. From everything I’ve read, it shouldn’t cause brain fog, the same way that finasteride does, as it shouldn’t affect the hormone profile, but who knows. I had persisting brain fog from finasteride already, so..... the whole chicken or the egg argument comes into play.
@strandman i haven’t tried those yet. Been following some stuff on another website. It seems like what finasteride does in our bodies that it messes with progesterone receptors amongst a bunch of other things, which cascades into brain and sexual hormones. Trying to avoid anymore drugs to fix it. Going to do a bunch of liver flushes and fasting. Did a hair test to try and get my minerals and nutrients back in balance. Hoping that helps. Did clinic have a positive effect for you?
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I am only bother to read the first sentence, and that was enough . "at very high dosages that are beyond most people's price range " How the hell you know how much it will cost when it hit the market ?! Plus this guy already made 3 phases for asthma , don't you think they have kind of an idea that it works in hair loss ?!
Buy it now, off label, from an underground lab, is not recommend it.
Right now, the thing is to use cetirizine, I am having great results with it.
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English isn't your first language.
That explains our miscommunication.
My condolences.
