Doubt on daily or weekly topical finasteride

trico

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Hey! Hello there, thanks for answering, I find myself very confuse about it. I and sorry for my english and the lack of knowledge, I have read a lot the forum before asking.

Supposedly, we are inhibiting this enzyme 5-alpha that destroy follicles. The little information I found about it (two papers here in the forum), said that it has a total spam life of about 88 hours (the reload time). If a 0,025% topical dose means the reduction of the enzime about 52% scalp and 25% serum, once applied the dose I have like half of 5-alpha inhibited in the scalp.

My first question is basically why have topical daily?
It is for the half life of finasteride? (like 5-14 hs).

In the spanish tecnical paper of finasteride oral it says that 39% dose eliminates trough urine (in the form of metabolites), and 57% percent in stool (thanks google translator). So its like 4% daily acumulation?

So there my second question: what do you think, are the posibilities of finasteride acumulation making it topically daily and how to avoid this (if possible)?

Thanks a lot for your help, I have learned a lot here!!
 
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