Drug ruxolitini grows back all hair within 5 months in majority of patients

[casperz]

Study done by Columbia University Medical Center on small number of alopecia areata patients.

http://www.nytimes.com/2014/08/18/health/alopecia-patients-in-study-grow-hair-with-new-drug.html?_r=0

http://www.livescience.com/47408-alopecia-areata-ruxolitinib-hair-regrowth.html

http://health.usnews.com/health-new...-drug-restores-hair-in-patients-with-alopecia


Maybe they'll find it works on male pattern baldness too but the current cost is $9000/month.

 

[2young2retire]

http://www.ema.europa.eu/docs/en_GB...ssessment_report/human/002464/WC500133226.pdf
that the cream form working for psoriasis

 

[qerqrqwrqwr]

does nothing for male pattern baldness though

 

[hellouser]

does nothing for male pattern baldness though

Please refrain from speculating.

 

[Python]

Interesting, but only a test will give us any hope

 

[I.D WALKER]

http://www.express.co.uk/news/uk/500588/Baldness-cure-here-in-five-years Here's a glimmer of Union Jack optimism I believe may promote a marginal degree of healthy encouragement. No, it's a hardly a recognized treatment for Androgenetic Alopecia or male pattern baldness and yes it's alleged potential is still an unyielding 5-10 years away, but I appreciated the overall sincerer tone and refreshing emphasis the author put's on underscoring a need for a solution.

 

[Notcoolanymore]

$9000/month...not bad...

You think inhouse will carry this?

 

[benjt]

http://www.express.co.uk/news/uk/500588/Baldness-cure-here-in-five-years Here's a glimmer of Union Jack optimism I believe may promote a marginal degree of healthy encouragement. No, it's a hardly a recognized treatment for Androgenetic Alopecia or male pattern baldness and yes it's alleged potential is still an unyielding 5-10 years away, but I appreciated the overall sincerer tone and refreshing emphasis the author put's on underscoring a need for a solution.

Unfortunately, that reporter has it all wrong.

a) male pattern baldness is a form of alopecia (as it is also known as androgenetic alopecia) and not something different
b) He is mixing up AA with "general alopecia except for Androgenetic Alopecia"
c) There is a connection between AA and Androgenetic Alopecia in that the symptoms of both are caused by immune system-like responses. In AA, the response is more direct, while in Androgenetic Alopecia, there is the mediator of DHT (and DKK downstream of it), combined with the fact that PGD is dual-function: PGs (like PGD and PGE) are both used in the immune system and in naturally in hair cycling (and in pregnancy by the way, too). By going out of hand, their function becomes closer to that usually witnessed in immune responses. Either way, the guy didn't even do sufficient googling, as you can see.
d) As we discussed already with the arthritis drug (which is similar to this case), there is no indication at all that this drug might be used for Androgenetic Alopecia/male pattern baldness, because the mechanism addressed is totally different.

Long story short: The website is uttering complete BS. While I am rather optimistic about the next few years (because of RepliCel), this drug will very likely not help us at all.

 

[bushbush]

Top health story on BBC news now as well: http://www.bbc.co.uk/news/health-28834058

"The patients all had alopecia - a condition that can cause severe, patchy baldness that is difficult to treat."

"It is not related to the more common male-pattern hair loss that is thought to be driven by hormones.
Scientists say as the mechanisms behind this condition are different, the therapy is less likely to prove effective for this more common problem."

While it is perfectly true the mechanisms might be different, there seems to be a general ignorance in acknowledging male pattern baldness as being a form of (androgenic) alopecia.

 

[I.D WALKER]

Your comprehensive insight on hair loss is always welcomed. So thank you for that. First off, if my post perpetuated more false hope for Androgenetic Alopecia/ M.P.B. "sufferers" as well as more unfounded speculation I apologize to all for my irresponsibility to objectivity. As it stands you are correct to clarify that these are distinctly 2 different forms of alopecia with 2 different mechanisms and more than likely require different modes of treatment. Discussing future hair loss treatments in general(ie; Replicel) I am pleased you are presently encouraged.

Unfortunately, that reporter has it all wrong.

a) male pattern baldness is a form of alopecia (as it is also known as androgenetic alopecia) and not something different
b) He is mixing up AA with "general alopecia except for Androgenetic Alopecia"
c) There is a connection between AA and Androgenetic Alopecia in that the symptoms of both are caused by immune system-like responses. In AA, the response is more direct, while in Androgenetic Alopecia, there is the mediator of DHT (and DKK downstream of it), combined with the fact that PGD is dual-function: PGs (like PGD and PGE) are both used in the immune system and in naturally in hair cycling (and in pregnancy by the way, too). By going out of hand, their function becomes closer to that usually witnessed in immune responses. Either way, the guy didn't even do sufficient googling, as you can see.
d) As we discussed already with the arthritis drug (which is similar to this case), there is no indication at all that this drug might be used for Androgenetic Alopecia/male pattern baldness, because the mechanism addressed is totally different.

Long story short: The website is uttering complete BS. While I am rather optimistic about the next few years (because of RepliCel), this drug will very likely not help us at all.

- - - Updated - - -

The article does not allege this is a viable treatment for M.P.B.. One positive interpretation I take from it is that that the missing piece(s) are looking smaller. At least for today.

 

[Mr White]

Guys, who cares if male pattern baldness is technically alopecia or not?! All we want to know is: does this ruxolitinib drug also work for male pattern baldness and has anyone actually tried it?

 

[bushbush]

Guys, who cares if male pattern baldness is technically alopecia or not?!

People who care how things work, and people who solve problems.

 

[intoleranz1]

any news to this?

 

[hellouser]

any news to this?

Nope, Dr. Brett King has ignored about 4 different emails I've sent him. Men with Androgenetic Alopecia are simply second class citizens that nobody gives a sh!t about.... not even doctors.

 

[benjt]

Conduct an experiment, hellouser. Send him an email about a topic not related to Androgenetic Alopecia. See if he replies. My guess is: He won't either. Conclusion: Him not responding has nothing to do with you having Androgenetic Alopecia. But hey, your persecution complex is nothing new.

 

[KiNGTyreZe]

Conduct an experiment, hellouser. Send him an email about a topic not related to Androgenetic Alopecia. See if he replies. My guess is: He won't either. Conclusion: Him not responding has nothing to do with you having Androgenetic Alopecia. But hey, your persecution complex is nothing new.

Push

 

[F2005]

I actually was on an alopecia areata site and apparently Dr. King is conducting a wider clinical trial using ruxolitinib for people with AA. The people on there raved about how nice and committed he was. He seems to be the exception to the rule: a doctor that tries to bring new drugs and hair regrowth methods to fruition, instead of tinkering on mice in a laboratory forever.

I wish Dr. King would perhaps make ruxolitinib into a topical cream and then try it on people with Androgenetic Alopecia. As a matter of fact, there was a very interesting thread on another hair loss forum where a guy suggested some type of derma-rolling to wound the skin, and then applying a topical cream of ruxolitinib to regrow hair.

There was a very interesting article presented from 1982 where a guy who had severe sunburn to his head regrew all of his hair after being on benoxoprofen: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1498062/?page=1. Although benoxoprofen is very dangerous to ingest, and was recalled years ago, it absolutely astounds me that no one has tried to use a topical version of similar drug to initiate hair regrowth.