Rogain has propylene glycol, water, and ethanol. Dutasteride is disolved in glycerol in a capsule. An MSDS for dutasteride says it is soluble in ethanol. I doubt they'd not mention right there that ethanol breaks down dutasteride if it did. Dutasteride is not soluble in water. However, the ethanol in Rogaine can keep it dissolved. Since the water in blood does not break down dutasteride, I doubt the 20% water in Rogaine will either. Propylene glycol is chemically similar to glycerol. So if dutasteride does not break down in glycerol for the life of the experiation date, I doubt it will break down in propylene glycol in a month. You can fill one of your empty bottles 1/4th full and add one capsule and refill each week if you are really worried. I recommend at least 2 capsule per bottle and highly doubt you will need 8, though others have used 8 with good results. See my other posts for my calculations on this. Do a google image search for propylene glycol and glycerol and you will see that they differ primarily by the number of OH groups. Since ethanol has only one and glycerol has 3 I think, I doubt propylene glycol, the intermediate molecule, will react with dutasteride. Everyone taking 1 capsule a day should drop to 6 capsules per week and add the other to their rogaine, or dilute their rogaine with 70% isoproply alcohol if the propylene glycol in Rogaine irritates their scalp too much. If you are on Finasteride, you are affraid your scalp won't absorb dutasteride, just take a least 1 dutasteride per week and you will get the same DHT inhibition you got on Propecia.
dusteride stability in Rogaine... my beliefs
- Thread starter CCS
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you said:
"If you are on Finasteride, you are affraid your scalp won't absorb dutasteride, just take a least 1 dutasteride per week and you will get the same DHT inhibition you got on Propecia."
Please, explain...
1)why should the scalp do not absorb dutasteride if on finasteride?
2)0.5mg oral dutasteride x week = same scalp inhibition as finasteride every day?
Thanks
"If you are on Finasteride, you are affraid your scalp won't absorb dutasteride, just take a least 1 dutasteride per week and you will get the same DHT inhibition you got on Propecia."
Please, explain...
1)why should the scalp do not absorb dutasteride if on finasteride?
2)0.5mg oral dutasteride x week = same scalp inhibition as finasteride every day?
Thanks
reducing dutasteride dose
1. Taking finasteride does not stop dutasteride absorption. But some people on here are affraid that not enough dutasteride will be absorbed through their scalp to risk stopping finasteride. If you want to take finasteride orally while taking dutasteride topically, great. But some people can't get prescriptions for both and are affraid to make the jump to just topicals for fear they won't absorb enough.
2. Yes, with Duts long half life, a pill a week (actually a capsule every 4 or 5 days if you want to be more exact) is about the same as finasteride. 0.1 mg/day dutasteride orally inhibits the same amount of scalp and serun dht as 5mg or 1mg finasteride. I think there is a small difference between 1 and 5 mg finasteride, like 65 vs 70% of serum dht, and both inhibit 38% of scalp dht, though it depends on the person.
0.5mg capsule/5 = 0.1 mg/day.
Warning: if you use Finasteride, take it daily. It has a half life of 4 hours. If you go more than 24 hours without it, your follicles will be under attack until you take more. It reaches steady state levels very quickly.
1. Taking finasteride does not stop dutasteride absorption. But some people on here are affraid that not enough dutasteride will be absorbed through their scalp to risk stopping finasteride. If you want to take finasteride orally while taking dutasteride topically, great. But some people can't get prescriptions for both and are affraid to make the jump to just topicals for fear they won't absorb enough.
2. Yes, with Duts long half life, a pill a week (actually a capsule every 4 or 5 days if you want to be more exact) is about the same as finasteride. 0.1 mg/day dutasteride orally inhibits the same amount of scalp and serun dht as 5mg or 1mg finasteride. I think there is a small difference between 1 and 5 mg finasteride, like 65 vs 70% of serum dht, and both inhibit 38% of scalp dht, though it depends on the person.
0.5mg capsule/5 = 0.1 mg/day.
Warning: if you use Finasteride, take it daily. It has a half life of 4 hours. If you go more than 24 hours without it, your follicles will be under attack until you take more. It reaches steady state levels very quickly.
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Re: reducing dutasteride dose
You DO know that it takes up to a week or two for DHT levels to get back to "normal" after the last dose of finasteride, right? Some guys take finasteride only every other day, or even every third day, with good results. There's even been some material in the medical literature about using it rather intermittently that way.
The reason that works, of course, has to do with the slow production rate of the 5a-reductase type 2 enzyme. Once finasteride knocks it out, it takes a while for new, "fresh" enzyme to be produced. The short half-life of finasteride itself doesn't have any impact on it.
Bryan
collegechemistrystudent said:
You DO know that it takes up to a week or two for DHT levels to get back to "normal" after the last dose of finasteride, right? Some guys take finasteride only every other day, or even every third day, with good results. There's even been some material in the medical literature about using it rather intermittently that way.
The reason that works, of course, has to do with the slow production rate of the 5a-reductase type 2 enzyme. Once finasteride knocks it out, it takes a while for new, "fresh" enzyme to be produced. The short half-life of finasteride itself doesn't have any impact on it.
Bryan
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collegechemistrystudent said:
The type 1 form of the enzyne is produced nearly twice as fast as type 2. That's one of the reasons that dutasteride is less potent against type 1 than type 2 (besides the fact that the dutasteride molecule is simply inherently less potent against type 1 than type 2): new, "fresh" type 1 is always being produced at a faster clip!
Bryan