Dutasteride 0.5mg daily increased my DHT and 3adiolG levels.

GRme11

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This a post since now I got my acc back which is worth mentioning. I was taking Dutasteride (Avodart) for almost 3 months, 0.5mg daily. And this happened:

***What I was taking from October 23rd until January 10th-I stopped it after this test. Plus, I stopped Pyri as well.

I was taking dutas in the morning and finasterde at night, orally, plus topical Pyrilutamide, etc. You can see my stack below:

Topical Minoxidil 6% (from 2018)

Topical Finasteride about 0.2% (from April 2022)

Oral Finasteride 1mg Propecia (from January 2020)

Oral Dutasteride from October 2022 (23rd)

17a-Estradiol/Alfatradiol/Pantostin 0.1% from June 2022

Cetirizine 1% from April 2022

Pyrilutamide 0.5% from September 2022 until my blood test I was taking it-Once daily


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My previous blood test (March 2022) of DHT and 3adiolG levels were: 35.5 ng/dl and 461 ng/dl, respectively. Range of my lab is: 30-85 ng/dl and 280-1900 ng/dl, respectively. I was using oral finasteride, topical finasteride, minoxidil, and I was about 2-3 weeks experimenting with increased topical finasteride dosages and 17a+ceti. I was still thinning and losing ground, of course.

New test (January 10): DHT went 56.3 ng/dl (!!!!!!) and 3adiolG went 1055 ng/dl (!!!!). As a tremendous upregulation or whatever! I performed this test they day before I stopped dutasteride, afer 80 days on it.

***3adiolG indirectly reflects 5AR activity in tissues!
http://immunotech.cz/Media/Default/Page/A-G_analyte_info.pdf
Plus, my thread here: https://www.hairlosstalk.com/intera...ation-of-hair-follicles-and-3a-diol-g.134542/
And of course this study which can add due to genetic variations:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746394/
 
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GRme11

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First off, I think alfatradiol is a waste. It’s a weaker form of estrogen, and I’ve never seen anyone have good results from it. It’s also a hormonal stimulus and may impact HPTA.

At the end of the day, I am a resultist. What works is what matters.

You have two main options here. You could try duta at 2.5mg, perhaps that would be strong enough to counter the upregulation. However, I have heard of and experienced hair worsening on dutasteride. I don’t like that approach especially since you have a test that validates it isn’t working for you. 2.5 could work but it’s a big risk, and truth be told I have yet to see someone have significant improvement on dutasteride compared to finasteride.

Why haven’t you tried oral minoxidil? It is the most powerful hair loss treatment aside from HRT. I would hop on oral minoxidil.

What are your DHT levels like on finasteride? What are you DHT levels like without these drugs?
Cetirizine and 17a Estradiol they are helping me a bit with the shedding, that’s why I keep using them, and also 17a mainly for the supposedly increase of aromatase, Cetirizine for pgd2.

I tried for few days 1mg (2 capsules) and again the same hair thin feeling so fast. So, I dropped it again. Also, I tried topical Dutasteride 0.25%, but again dropped it because it was making my scalp very tight and dry, and I believe it was from the 5AR1 inhibition. This was leading again to thinner hair.

I thought about oral minoxidil as well.

You can see my DHT on Finasteride above: My previous blood test (March 2022) of DHT and 3adiolG levels were: 35.5 ng/dl and 461 ng/dl, respectively. Range of my lab is: 30-85 ng/dl and 280-1900 ng/dl, respectively. I was using oral finasteride, topical finasteride, minoxidil, and I was about 2-3 weeks experimenting with increased topical finasteride dosages and 17a+ceti.

My baseline DHT was about 52-55 ng/dl. Without treatments.
 
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GRme11

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But I used it for 7 months, even if it was from Actifolic, mmax, or anageninc, I haven’t even notice a single improvement to my hair quality…..You forgot that I used from all 3 vendors…I think I am no responder to it….. So cursed….

Mmax has purity tests as well, also a guy in the reviews posted that he checked the purity of their pre made 5% solution and it came back good:


0006A099-2D97-4AE8-B1F5-23C483E45830.png
 

losingbattle88

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But I used it for 7 months, even if it was from Actifolic, mmax, or anageninc, I haven’t even notice a single improvement to my hair quality…..You forgot that I used from all 3 vendors…I think I am no responder to it….. So cursed….

Mmax has purity tests as well, also a guy in the reviews posted that he checked the purity of their pre made 5% solution and it came back good:


View attachment 186654
Its because you used dutasteride while on RU. Duta raise scalp T and cause upregulation. Duta fucked my hair after 1.5 years on it even at 2.5mg and 2mg. Also used topically.
 

GRme11

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Its because you used dutasteride while on RU. Duta raise scalp T and cause upregulation. Duta fucked my hair after 1.5 years on it even at 2.5mg and 2mg. Also used topically.
No, I only added RU into my regimen. I was not using Dutasteride when on RU… I dropped Dutasteride as I mentioned in my post, early January of 2023…
 

GRme11

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Added. What u mean. What did u use with RU?
Topical Minoxidil 6% (from 2018)

Topical Finasteride about 0.2% (from April 2022)

Oral Finasteride 1mg Propecia (from January 2020)
17a-Estradiol/Alfatradiol/Pantostin 0.1% from June 2022

Cetirizine 1% from April 2022

And I just added RU on top of that for 7 whole months…
 

losingbattle88

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Topical Minoxidil 6% (from 2018)

Topical Finasteride about 0.2% (from April 2022)

Oral Finasteride 1mg Propecia (from January 2020)
17a-Estradiol/Alfatradiol/Pantostin 0.1% from June 2022

Cetirizine 1% from April 2022

And I just added RU on top of that for 7 whole months…
Pantosin is trash. One guy said it can worsen hair drop it. I used it for 5 months didnt do jack sh*t
 

GRme11

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losingbattle88

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