Dutasteride, sexual sides, and cognitive sides...

[fro]

Ok...has anyone here used dutasteride and not experienced sexual side effects??

Also, has anyone experienced any cognitive side effects? These are what concern me the most. When dutasteride first came out, I asked my Doctor about it, and he said he wouldn't prescribe it because of all of the 5-AR type 1 that's swimming around in brain tissue, and it probably isn't an enzyme we want to blocking, given any potential "as-of-yet-unknown" side effects including cerebral neurotoxicity. Does anyone have any thoughts for me regarding this topic? I haven't been a regular member since 2004, so things may have changed a bit with respect to new dutasteride side effect findings or safety profile, etc.

Thanks!!:wave:

 

[Armando Jose]

This is a new study regarding neurosteroids

Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13100-5. doi: 10.1073/pnas.1210023109. Epub 2012 Jul 17.
Mild exercise increases dihydrotestosterone in hippocampus providing evidence for androgenic mediation of neurogenesis.
Okamoto M, Hojo Y, Inoue K, Matsui T, Kawato S, McEwen BS, Soya H.
Source
Laboratory of Exercise Biochemistry and Neuroendocrinology, Faculty of Health and Sports Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8574, Japan.
Abstract
Mild exercise activates hippocampal neurons through the glutamatergic pathway and also promotes adult hippocampal neurogenesis (AHN). We hypothesized that such exercise could enhance local androgen synthesis and cause AHN because hippocampal steroid synthesis is facilitated by activated neurons via N-methyl-D-aspartate receptors. Here we addressed this question using a mild-intense treadmill running model that has been shown to be a potent AHN stimulator. A mass-spectrometric analysis demonstrated that hippocampal dihydrotestosterone increased significantly, whereas testosterone levels did not increase significantly after 2 wk of treadmill running in both orchidectomized (ORX) and sham castrated (Sham) male rats. Furthermore, analysis of mRNA expression for the two isoforms of 5α-reductases (srd5a1, srd5a2) and for androgen receptor (AR) revealed that both increased in the hippocampus after exercise, even in ORX rats. All rats were injected twice with 5'-bromo-2'deoxyuridine (50 mg/kg body weight, i.p.) on the day before training. Mild exercise significantly increased AHN in both ORX and Sham rats. Moreover, the increase of doublecortin or 5'-bromo-2'deoxyuridine/NeuN-positive cells in ORX rats was blocked by s.c. flutamide, an AR antagonist. It was also found that application of an estrogen receptor antagonist, tamoxifen, did not suppress exercise-induced AHN. These results support the hypothesis that, in male animals, mild exercise enhances hippocampal synthesis of dihydrotestosterone and increases AHN via androgenenic mediation.

 

[LawOfThelema]

I use 0.5 mg every THIRD day. Sexual side is there but it's very bearable. I have a hard time even appraising its cognitive side due to being baseline anxious, depressed, and lethargic. Perhaps more headaches.

 

[antman]

thanks Armando Jose for that study

i'm 40 days now on 0.5mg Dutasteride per day, just like finasteride - no sides (still have morning wood)

i had problems at the start of the year but i am certain that was from being depressed

 

[Cassin]

Ok...has anyone here used dutasteride and not experienced sexual side effects??

Also, has anyone experienced any cognitive side effects?

There is a strong placebo effect.

 

[fro]

Thanks all for the feedback. Greatly appreciated :salut: