Elevated liver enzymes 1 year after Finas discontinuation

[TA45]

Hi guys,
I recently had bloodword done and they reported that my liver enzymes are almost double what they should be! It has been a little over 1 year since taking my last dose of Propecia. Could this still be an effect of taking the Propecia? I currently use Nizoral 1% once per week where I put a substantial amount on my scalp and rub it in vigorously and let stand for 5 minutes. Could it be that? I read the Ketokanozele can mess with the liver. Anyone?? Don't know if this helps but it takes me about 3 days to recover from exercise. Link? Thanks brainiacs!!!!

 

[Ende]

Exposing the scalp with 1% nizoral, 5 minutes once a week, is not the problem. It will not be absorbed into your system, as long as you don't get it in your eyes, nose or mouth. You should discuss this with your doctor.

 

[TA45]

Damn Eden, i'm nervous about this!

 

[Ende]

Yes, but noone here can answer your question. As far as I know, any oral medication can raise your liver values, although some are more likely to do it than others. Oral steroids are one example. I've never heard about propecia affecting the liver values, and like you say, it's one year since the last pill. I think it's something else, and that's why you should discuss this with your doctor. What did he say btw?

 

[Mew]

I've never heard about propecia affecting the liver values,

Finasteride is metabolized in the liver and has been associated with elevated liver enzymes.

http://www.propecia.com/propecia/shared ... nts/pi.pdf

"Finasteride is extensively metabolized in the liver, primarily via the cytochrome P450 3A4 enzyme subfamily."

"Caution should be used in the administration of PROPECIA in patients with liver function abnormalities, as finasteride is metabolized extensively in the liver."

FDA liver adverse reactions database -- elevated liver enzymes, search for "Finasteride"
http://www.fda.gov/downloads/AboutFDA/C ... 106561.pdf



Finasteride-induced Hepatitis
http://www.asiatox.org/6th%20APAMT%20pd ... atitis.pdf


http://www.ncbi.nlm.nih.gov/pubmed/10996351

"a direct and non-specific interference of the drug on liver metabolism cannot be excluded."

Here are some others' experience with this issue: http://www.keratin.net/forums/viewtopic.php?p=12592

 

[HT55]

I've never heard about propecia affecting the liver values,

Finasteride is metabolized in the liver and has been associated with elevated liver enzymes.

http://www.propecia.com/propecia/shared ... nts/pi.pdf
[quote:3v26clt5]"Finasteride is extensively metabolized in the liver, primarily via the cytochrome P450 3A4 enzyme subfamily."

"Caution should be used in the administration of PROPECIA in patients with liver function abnormalities, as finasteride is metabolized extensively in the liver."

FDA liver adverse reactions database -- elevated liver enzymes, search for "Finasteride"
http://www.fda.gov/downloads/AboutFDA/C ... 106561.pdf



Finasteride-induced Hepatitis
http://www.asiatox.org/6th%20APAMT%20pd ... atitis.pdf


http://www.ncbi.nlm.nih.gov/pubmed/10996351

"a direct and non-specific interference of the drug on liver metabolism cannot be excluded."

Here are some others' experience with this issue: http://www.keratin.net/forums/viewtopic.php?p=12592[/quote:3v26clt5]


The FEAR Monger returns, lol

Show us where someone had normal liver values and propeci messed them up ?

It's not a hard drug on the liver at all

 

[HT55]

1

 

[HT55]

Here are some others' experience with this issue: http://www.keratin.net/forums/viewtopic.php?p=12592

Seems legit to me, It can't be the heavy drinking, it must be Propecia because he said so, lol

Honestly, you can't make this sh*t up people and this guy Mew takes this as a fact ?




"I am glad to have come across this posting. My doctor recomended that I have my liver checked befor I went on propecia and it was normal. I have been on propecia for about a year and a half and I had my liver checked again and now my AST and ALT levels are high. I however do dirnk quite a bit of alcohol so I am not sure what the cause is. I just wanted to put in my two cents becuase I personally feel that it is due to the propecia and not the booze.

 

[dougfunny]

Exposing the scalp with 1% nizoral, 5 minutes once a week, is not the problem. It will not be absorbed into your system, as long as you don't get it in your eyes, nose or mouth. You should discuss this with your doctor.

I would not be so sure. These topical drugs almost always get into your system to some extent.

You're exposing yourself to a drug with a well known connection to liver problems. I would stop using it immediately and recheck your blood levels after a couple of months.

Better safe than sorry.

 

[Ende]

I'm using 2% nizoral every day. I've been doing so for the last year, and I'm exposing the scalp 1 - 4 minutes, depending on seborrheic dermatitis symptoms. I'm using a shitload of other drugs in addition, but none are known to be harsh on the liver. I recently checked the values, and they were normal. Everyone is different though, and if you've a weakness with the liver... Well, but I still doubt that washing the hair with 1% nizoral once a week, according to the instructions, is the reason.

 

[dougfunny]

Everyone is different though

It's not a weakness of the liver. It's a sensitivity to the drug.

 

[Ende]

Everyone is different though

It's not a weakness of the liver. It's a sensitivity to the drug.

Or that, but still...

 

[HT55]

Everyone is different though

It's not a weakness of the liver. It's a sensitivity to the drug.

Topical Nizoral is not causing liver problems

You either have pre existing liver problems or other drugs/alcohol is the issue

 

[barcafan]

the drug can definitely break your htpa, then if not fixed, your enzymatic pathways can get fucked up, your liver will be overloaded trying to clear them out.

 

[TA45]

K guys, thank you all for your input.
To answer your questions/comments:
My Dr. told me to come back and get more blood work done. The odd thing is...the results are still pending. It has been 5 days since the 2nd round of bloodwork has been completed. I'm surprised it is taking so long.

hair transplant 55 made a comment about the elevated enzymes being a result of drinking and drug use. No, that woould be incorrect. I don't take any drugs and I drink about 3 beers a week....
I really don't understand what iis going on with my body these days....

 

[Todd]

What type of enzymes were elevated?

 

[TA45]

AST

 

[Todd]

Do you mean ASAT?

Was only ASAT elevated, or was ALAT elevated as well? What was the ASAT/ALAT ratio?
ASAT, is also abundant in muscular tissue; could be elevated in plain muscle tissue lesions.
ALAT is more specific to the liver; usually a high ALAT is the most important clinical marker for liver cell damage.

High ASAT with low ALAT (high ASAT/ALAT ratio) is not a good sign, however, could be mitochondrial damage. ASAT/ALAT- ratio should ideally be 1.
If it´s over 2,5 you REALLLY should see a doctor.

Stay off the finasteride if you feel this is what caused it.

 

[TA45]

Todd you have me concerned.
Yes, the results show elevated "AST" 79 (10-40 is the range)
My "ALT" showed 36 (9-60).

You mention something about muscle legion?? I can tell you I have had something going on in my right leg thigh area that first began last year when I tried Finasteride again. I get mild leg discomfort going from anywhere from my hip area to directly right above my knee. Sometimes different muscles in my thigh twitch like crazy too! It's weird in that one day the discomfort could be right above my knee, the next day it moves to my hip area, the next day it could be right in the middle of my thigh... and so on. No real bad pain here, just discomfort and twitching.... What you think? Anybody?

 

[Todd]

Ok, so your ASAT is a little high, and your ALAT is within range.

ALAT is an enzyme which is very specific for the liver.
ASAT, while specific for liver mitochondria, is also abundant in muscular tissue, and heart muscle.

Usually when one suspects liver damage, one sees both high ALAT and ASAT. (cells are damaged, they leak enzymes out in plasma)
With severe liver necrosis, ASAT is higher than ALAT; this is because the liver is so damaged that ALAT isn´t produced. THIS IS NOT THE CASE FOR YOU, YOUR ALAT IS NORMAL AND YOUR ASAT ISN´T REALLY THAT HIGH.

True, it´s above the reference, but it would have to be double or triple what it is now for any pathological difference.

Good news: you are probably idiopatically high in ASAT.


However, and I cannot stress this enough: if you are really worried don´t listen to some amateur on the net, go see a doctor you trust.