Estradiol-17alpha - Topical Usage Question

[Towlie123]

not sure if this is the right place to ask this.

went to a place, they make they own solution, to be applied topically.

it contains 5% minoxi, which is ok by me.

but also, 0.05% estradiol-17alpha, which im not sure what can cause.

i understand its steroidal estrogen, but i cant find much info on what it might cause.

anyone have some info about it? some related research?

any info will be much appreciated.

thanks!

 

[Maave]

It will be similar to estrogel which is 0.06% estradiol. Estrogel uses a measured pump for dosage and may have a different absorption rate than their compound. It's bioidentical estrogen, it behaves just like the body's estrogen. Some amount of the estrogen will go systemic. Small amounts are fine, men have normally small amounts of estrogen, but too much can cause gyno or reduce your natural testosterone production.

Estrogen is generally good for hair but I don't know why they chose it over an anti-androgen. They could have used finasteride or spironolactone.

EDIT
I wasn't paying attention and thought it was a 17beta-estradiol. 17alpha-estradiol is different, much less potent
https://en.wikipedia.org/wiki/Alfatradiol

 

[hemingway_the_mercenary]

It will be similar to estrogel which is 0.06% estradiol. Estrogel uses a measured pump for dosage and may have a different absorption rate than their compound. It's bioidentical estrogen, it behaves just like the body's estrogen. Some amount of the estrogen will go systemic. Small amounts are fine, men have normally small amounts of estrogen, but too much can cause gyno or reduce your natural testosterone production.

Estrogen is generally good for hair but I don't know why they chose it over an anti-androgen. They could have used finasteride or spironolactone.

this is 17a not 17b estradiol

as far as I know its a 5ar inhibitor (i dont think thats all it is, maybe it dose more too) and a study found that it helped regrow hair after chemotherapy or something like that

 

[Maave]

this is 17a not 17b estradiol

as far as I know its a 5ar inhibitor (i dont think thats all it is, maybe it dose more too) and a study found that it helped regrow hair after chemotherapy or something like that

Thanks I missed that. That's way weaker

 

[Towlie123]

way weaker in what way?

i obviously prefer something that might have less chances of helping but in the same time is much safer.

so what do you mean by way weaker?

and about why not using anti-androgen. isnt anti-androgen causes less production of testosterone in the body? and correct me if im wrong, but estradiol shouldnt cause that?

again, thanks for any help!

 

[Maave]

It's weaker because it has a lower binding affinity to estrogen receptors and less estrogenic activity.
https://en.wikipedia.org/wiki/Alfatradiol

it has 100-fold lower estrogenic activity relative to estradiol

Also interesting, it can act like finasteride:

Alfatradiol acts as an inhibitor of the enzyme 5α-reductase

This sounds a lot safer than I initially thought.

and about why not using anti-androgen. isnt anti-androgen causes less production of testosterone in the body? and correct me if im wrong, but estradiol shouldnt cause that?

Estrogen can downregulate the HPG axis which controls your body's hormone production. It lowers LH and FSH which trigger testosterone production. I can't find studies regarding 17a-estradiol but it sounds like the effect should be negligible at those doses. Using a topical solution lessens this effect as well.

 

[arnoldd]

I wanted use it months ago but its very expensive in my country. It hasnt any side effects but the efficacy is poor..

 

[Towlie123]

hey, sorry for the bump. but actually gonna start using it.
just wanted to make sure, if i understand it correctly, unlike finasteride, it shouldnt do anything with DHT levels, and sounds safe?
i talked with my doctor and wanna have blood test for testostorone level before using just in case. am i missing something?

im not talking about how effective it is, just talking side effects only.
trying to make sure its safe to use, as i have no intentions of using finasteride or so.
thanks!

 

[Towlie123]

It's weaker because it has a lower binding affinity to estrogen receptors and less estrogenic activity.
https://en.wikipedia.org/wiki/Alfatradiol



Also interesting, it can act like finasteride:



This sounds a lot safer than I initially thought.


Estrogen can downregulate the HPG axis which controls your body's hormone production. It lowers LH and FSH which trigger testosterone production. I can't find studies regarding 17a-estradiol but it sounds like the effect should be negligible at those doses. Using a topical solution lessens this effect as well.

"and 5α-reductase inhibitor "

so if it acts like finasteride, it might have the same side effects?

 

[arnoldd]

"and 5α-reductase inhibitor "

so if it acts like finasteride, it might have the same side effects?

No bro. There isnt any side effect , it doesnt affect the hormones like finasteride do. Dont expect big results, it can only slow down the hair loss progression but dont expect regrowth.

 

[Towlie123]

thanks for the answer mate
but where do you take that info from?

i admit i might be abit scared. wouldnt touch propecia. i prefer losing hair, that hurting my body. but im ok with trying things that seems safe, even if they might be somewhat less effective.

so, couldnt find much research about side of it on men, any help?

 

[arnoldd]

thanks for the answer mate
but where do you take that info from?

i admit i might be abit scared. wouldnt touch propecia. i prefer losing hair, that hurting my body. but im ok with trying things that seems safe, even if they might be somewhat less effective.

so, couldnt find much research about side of it on men, any help?

i took the info from the leaflet and from the net. yep its totally safe, it dont affect the hormones so you wont need any bloodtest. im taking it from 2 months and there isnt any side effect i noticed.
you can try also ketoconazole 2% shampoo. it will help too against hair loss and it doesnt go systemic.

 

[Towlie123]

if its not too personal, may i ask if your also using propecia, or other kind of antiadrogens?
or the reason youre using Alfatradiol is because you dont want any sides?

 

[arnoldd]

if its not too personal, may i ask if your also using propecia, or other kind of antiadrogens?
or the reason youre using Alfatradiol is because you dont want any sides?

No, im only using alphaestradiol and saw palmetto (which is supposed to be a natural substitute to finasteride) and essential oils. I got an allergic reaction from finasteride in the past so i cant take it anymore.

 

[Towlie123]

if saw palmetto suppose to act like finasteride, any reason to still use alphaestradiol?

 

[arnoldd]

if saw palmetto suppose to act like finasteride, any reason to still use alphaestradiol?

Like you said it is supposed to act like a weak finasteride, but there isnt any real evidence yet.

 

[dezertfox]

not sure if this is the right place to ask this.

went to a place, they make they own solution, to be applied topically.

it contains 5% minoxi, which is ok by me.

but also, 0.05% estradiol-17alpha, which im not sure what can cause.

i understand its steroidal estrogen, but i cant find much info on what it might cause.

anyone have some info about it? some related research?

any info will be much appreciated.

thanks!

Can you let me know where you bought it, if in US? I am looking to buy as well..

 

[tomJ]

No, im only using alphaestradiol and saw palmetto (which is supposed to be a natural substitute to finasteride) and essential oils. I got an allergic reaction from finasteride in the past so i cant take it anymore.

How is it working for you so far? Any shedding reduction?? Please offer your insight

 

[tomJ]

Like you said it is supposed to act like a weak finasteride, but there isnt any real evidence yet.

What is the name of the alpha estrodial product that you use? Thank you