Estriol, The Least Potent Estrogen, Topically

[Fanjeera]

Why not use topical estriol on the hair? Estriol is the weakest estrogen and probably the least fat-soluble, meaning least absorbable through the skin, as well. It's more an end-metabolite than an active hormone and as you get to the end of metabolism of hormones and other substances you get less bioactivity and more water-solubility because they need to be excreted with urine somehow which needs water-solubility.

It is a very common product on the market for women for topical use in vagina. Supercheap too.

Has anyone tried it?

As we known, estrogen is especially good for the hairline. Men with higher estrogen levels get only diffuse thinning no receding hairline.

Got the idea from this guy: https://www.hairlosstalk.com/intera...-G6XUtavDkvatJu7DFQ8M8IIEDq8NMCNb6-CWxpDFbMB0

But he's using estradiol, the most potent and systemic female hormon!

https://en.wikipedia.org/wiki/Estriol#Biological_activity

"the relative binding affinity (RBA) of estriol for the human ERα and ERβ was 11.3% and 17.6% of that estradiol, respectively, and the relative transactivational capacity of estriol at the ERα and ERβ was 10.6% and 16.6% of that of estradiol,"

https://www.researchgate.net/figure...ation-of-Human-Sexual-Hormones_tbl1_269187779

So only 50% gets absorbed, maybe even less. https://en.wikipedia.org/wiki/Estriol_(medication)#Absorption

Less absorbed, less side effects.

 

[INT]

Give it a try an report back to us

 

[whatevr]

I use it most days of the week (the estriol from Life-Flo health from iHerb). No estrogenic side effects, in fact some days it seems to give me more energy, possibly through displacing the stronger estrogens from the estrogen receptor and acting as an anti-estrogen, in a sense (due to estriol being so weak, think similar to how RU competes for the androgen receptor but has very little to none androgenic activity of its own, thus being antiandrogen).

That said I can't say it does much for my hair at all, and I wouldn't expect it to, given its weakness. Perhaps on a stack with really strong anti-androgens, it could slowly, slowly, give you regrowth. But you need to have all the DHT-driven damage already under control.

 

[Fanjeera]

I use it most days of the week (the estriol from Life-Flo health from iHerb). No estrogenic side effects, in fact some days it seems to give me more energy, possibly through displacing the stronger estrogens from the estrogen receptor and acting as an anti-estrogen, in a sense (due to estriol being so weak, think similar to how RU competes for the androgen receptor but has very little to none androgenic activity of its own, thus being antiandrogen).

That said I can't say it does much for my hair at all, and I wouldn't expect it to, given its weakness. Perhaps on a stack with really strong anti-androgens, it could slowly, slowly, give you regrowth. But you need to have all the DHT-driven damage already under control.

I use minoxidil already. That was lately shown to be anti-androgenic.

 

[Fanjeera]

Bought this. Very comfortable to use and hold in hand. Though a little bit pressure has to be applied, which may be traumatic for the already brittle hair.

I just hope the hormone is distributed evenly everywhere inside the candle, not just maybe in the core of it. Probably better to dissolve it and use as a solution still. The 60 ml Rogaine bottle is too small for enough dosage probably.

 

[tomJ]

View attachment 141262

Bought this. Very comfortable to use and hold in hand. Though a little bit pressure has to be applied, which may be traumatic for the already brittle hair.

I just hope the hormone is distributed evenly everywhere inside the candle, not just maybe in the core of it. Probably better to dissolve it and use as a solution still. The 60 ml Rogaine bottle is too small for enough dosage probably.

Please report back. Thankyou

 

[LouisSarkozy]

what about using pantostin? its a 17α-estradiol so do you think being a weak oestrogen it also compete with scalp testoterone receptor in a similar way to RU ? sry for asking that but i'm looking for smthing weak side effect free and affordable aswell as easy to get my hands on to specifically target scalp testosterone.

 

[Fanjeera]

Damn, these candles don't dissolve at all in 60 ml Regaine 5% . I really doubt I get any estriol this way.

 

[SteveTabernack]

Tried topical estriol cream for months. Hair wise I didn't notice anything unfortunately.

 

[Obsessive]

I use it most days of the week (the estriol from Life-Flo health from iHerb). No estrogenic side effects, in fact some days it seems to give me more energy, possibly through displacing the stronger estrogens from the estrogen receptor and acting as an anti-estrogen, in a sense (due to estriol being so weak, think similar to how RU competes for the androgen receptor but has very little to none androgenic activity of its own, thus being antiandrogen).

That said I can't say it does much for my hair at all, and I wouldn't expect it to, given its weakness. Perhaps on a stack with really strong anti-androgens, it could slowly, slowly, give you regrowth. But you need to have all the DHT-driven damage already under control.

How many mgs of estriol are you using? 1 have tried 1-2 mg day on both body and scalp and didn't notice much in hair benefits. Have you tried a higher dose?

 

[Sanchez1234]

Tried topical estriol cream for months. Hair wise I didn't notice anything unfortunately.

At what dose?

 

[tomJ]

Going to start using a minimum of 40mg/day soon. Should work a lot better at that dosage.

Please update us.

 

[whatevr]

How many mgs of estriol are you using? 1 have tried 1-2 mg day on both body and scalp and didn't notice much in hair benefits. Have you tried a higher dose?

Hard to say exactly, but:

"Each full press of the pump provides approximately 0.75 mg of natural Estriol USP."

I use a lot less than a full press, perhaps a 1/5th of a press or so, it's an amount that can fit on your fingertip. Now I realize this is a pathetic dose.

 

[Fanjeera]

Damn, these candles don't dissolve at all in 60 ml Regaine 5% . I really doubt I get any estriol this way.

I put them next to my radiator and they all dissolved quickly. Nice. They just need 36 degrees C. I can probably add even more estriol now to my 60 ml of Regaine 5%. So I have 2,5 mg-s of estriol in it right now and I'm only applying to my temple points, so maybe that's enough. Will add more.

 

[Sanchez1234]

What would be a good daily dose?

 

[SteveTabernack]

At what dose?

Concentration was 1 % but I don't know how much I applied really. I tried to do as little as possible to cover the baldie areas.

 

[coco_304]

Where to smear the gel??

 

[Sanchez1234]

So to summarize. The theory is that because estriol is the only natural estrogen with a greater ER-beta (good for hair) affinity than ER-alpha (bad for hair) we should trial that instead of estradiol.

If we get the right dose we get the same benefits as estradiol without all the bad sides from ER-alpha which Estradiol give.

So couple of questions;

1. This is not new information. A lot of sh*t has been trialed on HairLossTalk.com. Really nobody tried high dose of estriol? Why not? Anybody knows highest dose that has been tested?

2. Anybody got information how much more potent 1mg of estradiol is compared to 1mg of estriol?

 

[jazz1]

what about using pantostin? its a 17α-estradiol so do you think being a weak oestrogen it also compete with scalp testoterone receptor in a similar way to RU ? sry for asking that but i'm looking for smthing weak side effect free and affordable aswell as easy to get my hands on to specifically target scalp testosterone.

I read about this stuff, hard to obtain in the UK as they are based in Germany.......

 

[LastHope123]

View attachment 141262

Bought this. Very comfortable to use and hold in hand. Though a little bit pressure has to be applied, which may be traumatic for the already brittle hair.

I just hope the hormone is distributed evenly everywhere inside the candle, not just maybe in the core of it. Probably better to dissolve it and use as a solution still. The 60 ml Rogaine bottle is too small for enough dosage probably.

Why not buy the Ovesterin cream instead? 0.1% estriol. OTC in most places.