Every other day?
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zackb said:
I don't think its correct.
0.5mg Dutasteride inhibits ~ 92% serum DHT and 55% scalp DHT
2.5mg Dutasteride inhibits ~ 95% serum DHT and 82% scalp DHT
The scalp DHT is different between different doses, though I think it still will be more effective than 1 mg finasteride.
Siberian
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I read somewhere - forget where now - that the idea is you can can skip doses for awhile (because of the long half-life), but you still need to maintain the correct dosage in TOTAL over time.
That is, you can either take one pill every day, or swallow seven pills once a week. Not recommended, but in theory anyway.
That is, you can either take one pill every day, or swallow seven pills once a week. Not recommended, but in theory anyway.
Aplunk1
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I've heard that dutasteride CAN be used, daily (or at the total weekly dosage taken once per week) for an entire year, then the dosage frequency can be reduced to maintain dutasteride blood levels.
If that makes any sense.
Goddamn. Killing too many brain cells. Better quit drinking.
If that makes any sense.
Goddamn. Killing too many brain cells. Better quit drinking.
Siberian
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Looking at http://www.dutasteride.org/dutasteride/ ... esults.htm, it seems taking .5mg every other day (same as .25 every day) isn't really much more effective than Propecia. A bit better, yes, but not by much.
Siberian
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jeffsss said:
Well no, as the dosage decreases, so does the effectiveness (rated by hairs regrown, which is all we really care about). It looks like .1mg only grows as much hair back as Propecia. So taking 1 Avodart pill every 5 days is no better than taking Propecia every day. Taking Avodart every 2 days is an improvement in hair count, but not by much - though that's a subjective judgement call everyone has to make for themselves.
Siberian
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IDOASIS said:
I knew someone would mention that, lol...
According to Merck, whether you take 1mg finasteride or 80mg (they literally say this), you'll grow back the same amount of hair.
It SEEMS that since it's a type II inhibitor only, it max's out at around 70% DHT suppression. You just can't inhibit any more DHT without going after the Type I thing too, like Avodart does. At least that's the conclusion I've come to.
Siberian said:
As far as I remember there is a different between 5 mg and 1 mg finasteride.
http://www.hairlosstalk.com/download/finmicro.pdf
I know the 1 mg was tested 6 months and the 5 mg 1 year ,but it is still a huge different 77 compare to 95 (haircount).
The Dht levels are the serum and not the scalp.
Siberian
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IDOASIS said:
Nearly all of that difference is from the duration difference. Reports vary, but Merck seems to suggest maximum regrowth occurs after one year on Propecia. Hence, the 6-month measurement of Propecia is unfair.
Still, I stumbled upon http://www.physics.upenn.edu/facultyinf ... index.html just now, which supports your idea that 5mg finasteride might be better than 1mg since the scalp DHT is reduced a bit more. It looks like the peak scalp DHT supression occurs at a higher dose than serum supression. It's a significant difference, but not astounding.
But back to the original topic, I fear many dutasteride users think that the longer half-life allows them to skip days AND maintain the same effectiveness. But the data doesn't support this. Taking one Avodart every other day won't grow as much hair as taking it every day.
On the other hand, it looks like as little as .05mg finasteride is as good as 1mg... with even 5mg being only slightly better. At least as far as scalp DHT levels go. I'm not sure if that translates into hair growth though.
Siberian said:
http://www.regrowth.com/hairloss-remedy ... esults.cfm
Scalp DHT measurements were also assessed for both DHT and Testosterone. Scalp DHT was decreased 27% for 0.05mg Dutasteride, similarly for Finasteride (38%) and Dutasteride 0.1mg (37%), 54% for 0.5mg, and 82% for 2.5mg Dutasteride. Rittmaster concluded that these results show that most of the DHT in the scalp comes from type 1 5-alpha reductase.
So which of the links is true???
Is it possible that finasteride reduces more scalp DHT than dutasteride??
Re: Bottom line?
You can get generics and save a lot of money.
Siberian,
Its either Merk or Glaxo lie.
It is not possible that there is more type 1 5-alpha than 2, and finasteride blocks 70% scalp DHT,
and it is not possible that finasteride inhibits more scalp DHT than Dutasteride.
zackb said:
You can get generics and save a lot of money.
Siberian,
Its either Merk or Glaxo lie.
It is not possible that there is more type 1 5-alpha than 2, and finasteride blocks 70% scalp DHT,
and it is not possible that finasteride inhibits more scalp DHT than Dutasteride.