OK I am not sure why this post has been ignored, just because it doesn't involve an anti androgenic agent...
Here is the link to the pdf paper (it's interesting, have tried on human cells in vivo earlier) :
http://www.jstage.jst.go.jp/article/bpb/32/8/1347/_pdf
The journal is a repectable one (anyone correct me, i did some research on it, e.g.
http://www.icsu-asia-pacific.org/resour ... urnals.pdf )
here is the discussion at the end of the article:
The author’s previous study showed that FFC stimulated
the proliferation of cultured keratinocytes, melanoblasts, and
melanocytes in newborn mice.4) FFC also stimulated the proliferation
of cultured fibroblasts derived from newborn mice
(Hirobe, unpublished). FFC also stimulated the differentiation
of murine keratinocytes and melanocytes.5) Moreover,
FFC stimulated the proliferation of cultured normal human
keratinocytes, fibroblasts, and melanocytes.6)
The present
findings in vivo confirm the author’s previous studies using
murine and human skin cells in vitro. Considering all these
findings, it is conceivable that FFC can stimulate the proliferation
of mouse and human keratinocytes, melanocytes, and
fibroblasts.
FFC was also found to stimulate hair growth and
to inhibit the alopecia hair-loss in this study. Since the hair
growth is regulated by the proliferation and differentiation of
keratinocytes, melanocytes, and fibroblasts,7) it is reasonable
to think that FFC is involved in the homeostasis of the skin
and hair by regulating the proliferation and differentiation of
keratinocytes, melanocytes, and fibroblasts.
In the present study, FFC Plain was more effective than
Moisture in stimulating the proliferation of fibroblasts and
melanocytes, and in inhibiting the alopecia. Although the
reason why FFC Moisture is less effective than Plain cannot
be fully explained at present, it might be due to the inhibitory
effect of rose oil, grape seed oil, jojoba oil, and the emulsifiers
present in Moisture.
The proliferation and differentiation of mammalian keratinocytes
are regulated by numerous factors, including epidermal
growth factor (EGF),17) keratinocyte growth factor
(KGF),18) hydrocortisone,19) and dexamethasone.19) The proliferation
and differentiation of mammalian fibroblasts are
regulated by basic fibroblast growth factor (bFGF),20) acidic
FGF (aFGF),20) transforming growth factor b 1,21) KGF,21) interleukin
(IL)-1a ,21) IL-1b ,21) and platelet-derived growth
factor.22) Moreover, the proliferation and differentiation of
mammalian melanocytes are regulated by melanocyte-stimulating
hormone,10,13,23,24) endothelin (ET)-1,25—27) ET-2,27) ET-
3,27) bFGF,28) steel factor,29,30) leukemia inhibitory factor,31)
granulocyte-macrophage colony-stimulating factor,32,33) and
hepatocyte growth factor (HGF).34,35) Mammalian hair
growth is also stimulated by insulin-like growth factor-I,36)
HGF,37) RET tyrosine kinase,38) bone morphogenetic protein,
39) estrogen,40) macrophage-stimulating protein,41) FGF-
18,42) and nerve growth factor.43) It should be emphasized
that FFC can stimulate the proliferation and differentiation of
keratinocytes, melanocytes, and fibroblasts as well as hair
growth without adding these growth factors, cytokines, and
hormones to skin lotions. FFC may activate these factors and
stimulate signaling pathways44—46) elicited by these factors.
Furthermore, it is possible that FFC changes the homeostatic
conditions within the skin and hair cells to those favorable
for the stimulation of proliferation and differentiation.
It is unknown at present what factors cause alopecia in
B10 mice. The growth factors and cytokines involved in regulating
the proliferation and differentiation of the three cell
lineages in the skin might be defective in the alopecia mice.
It may be possible that FFC treatment restores the defects
in the expression of the genes associated with the proliferation
and differentiation of keratinocytes, fibroblasts, and
melanocytes. However, this hypothesis remains to be investigated
in a future study.
In the present study, the proliferation and differentiation of
keratinocytes, fibroblasts, and melanocytes were stimulated
by FFC. Thus, FFC seems to affect these growth factors, cytokines
and hormones in vivo, and bring the changes of renewal
of 3 cell types that constitute skin and hair followed by
the homeostasis of skin and hair. Stimulation of the proliferation
and differentiation of keratinocytes, fibroblasts, and
melanocytes by FFC may be helpful in maintaining the
health and youthfulness of the skin and hair. Thus, it is reasonable
to think that FFC can maintain the health and youthfulness
of skin and hair through the activation of the proliferation
and differentiation of keratinocytes, fibroblasts, and
melanocytes.
