Finasteride: 0.2mg is at least 80% to 90% Effective as 1mg

[blakes30]

DHT Reduction:

Study 1) 0.2mg is 90% as effectve as 1mg;
61.7% at 0.2mg to 68.7% at 1mg, 61.7/68.7 = 90%

Study 2) 0.2mg is 94% as effectve as 1mg;
53.95% at 0.2mg to 57.56% at 1mg, 53.95/57.56 = 94%


Observed Haircount Increase:

Study 1) 0.2mg is 79% as effective as 1mg;
61 vs 77 increased hair count, 61/77 = 79%

Study 2) 0.2mg is 80% as effective as 1mg;
54.9 vs 68.7 increased hair count, 54.9/68.7 = 80%

Study 1 is from K.D. Kaufman's double-blind controlled studies
Study 2 is the data Merck submitted to the FDA

As you can see, 0.2mg is somewhere between 80% and 90% as effective as 1mg. I would tend to err on the side of 90%, since "Observed Haircount Increase" is a subjective measurement. Further, Sherman Frankel's analysis of the data did not show any "statistically significant difference" at a 95% Confidence Interval. This showed that while the numbers varied somewhat, the errors of estimate were such that 0.2mg and 1mg were not different at all.

Either way---0.2mg is very close to the same results as 1mg, and I would guess that 0.5mg is 100% as effective as 1mg, since 0.5mg is two and one half times the dosage of 0.2mg!!!

 

[yukoncornelius]

Thanks for this data, the 1mg propecia tablet cutting begins tonight... hopefully the shedding isn't bad, and my anxiety/brain fog side effects go down drastically. If not, I think i'll move on to losing my hair and keeping my mental state of my mind. I'm gonna go bald eventually, might have to get used to having a tan head and a buzz cut

 

[Bryan]

Re: Finasteride: 0.2mg is at least 80% to 90% Effective as

As you can see, 0.2mg is somewhere between 80% and 90% as effective as 1mg. I would tend to err on the side of 90%, since "Observed Haircount Increase" is a subjective measurement.

For maximum relevance and accuracy, it's more logical to compare the effects of the two doses versus placebo, not just the absolute increases in haircounts over baseline.

Bryan

 

[Far Too Young]

Yep, here it is Yukon. I'd say cut away. At that rate .5 milligrams should prove a very minimal change in primary effectiveness.

 

[blakes30]

Re: Finasteride: 0.2mg is at least 80% to 90% Effective as

As you can see, 0.2mg is somewhere between 80% and 90% as effective as 1mg. I would tend to err on the side of 90%, since "Observed Haircount Increase" is a subjective measurement.

For maximum relevance and accuracy, it's more logical to compare the effects of the two doses versus placebo, not just the absolute increases in haircounts over baseline.

Bryan

It is my understanding that those numbers ARE compared to placebo. Placebo had no siginificant effect on DHT reduction. Comparison to Placebo would be the same for both doses, since placebo had no reversal effects on hair loss either. Placebo is identical to 0mg of finasteride---which results are independent of other doses.