Finasteride inhibits type 2 5ar by 70% and dutasteride more than 90%. However studies conclude that finasteride and dutasteride reduce scalp dht by only 40% and 50% respectively. Shouldn’t the scalp dht figures be a lot higher than this? How is this possible? But then i have read that scalp dht has no bearing on hair loss. I am very confused.
finasteride/dutasteride dht inhibition (title should be 7 words)
- Thread starter Kai_21
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and thats all that truly matters for hair loss?
but if dutasteride only reduces scalp dht by 50% isn’t that why it may not work for some. However as i said ive read scalp dht does not matter.
I read this on this forum :
It's around the 90s inside the follicle, which is what matters. Scalp DHT levels mean little. Serum DHT levels mean nothing.
the ratio your doing is off. Dutasteride and Finasteride work for everyone, in terms that they slow down or halt hair loss. Basic studies demonstrate that finasteride can maintain (meaning keeping you at baseline which is the day you start) or better for 85-95% of individuals based on the 3 large long term studies done in the last decade.
your looking at the science and being to basic when looking how and why they work, which is causing you confusion when you see the scalp dht being suppressed by only 40-60%. 5AR2 deficient men had normal test and normal levels of 5AR1 meaning they did have dht. These men never have any noticeable hair loss, they are are still losing some hair although it’s not cosmetically noticeable over there life. Also take into account that they are basically mimicking finasteride users but started at 12-13 years old.
The best thing is always prevention, I know many individuals who started finasteride before they had aggressive hair loss and have maintained for 9-12 years as of today. In science is always more difficult to cure and reverse then it is to prevent.
your looking at the science and being to basic when looking how and why they work, which is causing you confusion when you see the scalp dht being suppressed by only 40-60%. 5AR2 deficient men had normal test and normal levels of 5AR1 meaning they did have dht. These men never have any noticeable hair loss, they are are still losing some hair although it’s not cosmetically noticeable over there life. Also take into account that they are basically mimicking finasteride users but started at 12-13 years old.
The best thing is always prevention, I know many individuals who started finasteride before they had aggressive hair loss and have maintained for 9-12 years as of today. In science is always more difficult to cure and reverse then it is to prevent.
Because its a mixture of what’s happening at the androgen recepotor, density of 5AR in the scalp, how big a role 5AR1 plays in hair loss (studies with 5AR1 inhibitors showed poor results) and average level of androgen sensitivity on the scalp.
the most important is starting finasteride or dutasteride before you experience hair loss to a bad degree. Again this isn’t suggesting you get on it, this is only taking into account the hair loss spectrum and not the rest that comes with finasteride.
the most important is starting finasteride or dutasteride before you experience hair loss to a bad degree. Again this isn’t suggesting you get on it, this is only taking into account the hair loss spectrum and not the rest that comes with finasteride.
thank you. I started finasteride 3 months ago and have gone from norwood 1.5 to 1. Very pleased. Just want to gather a greater understanding of hair loss really before i start low dose test in the new year. But as you said ‘5AR2 deficient men had normal test and normal levels of 5AR1 meaning they did have dht.’ So does that mean that they had normal levels of scalp dht? Therefore inhibiting the 5 ar 2 enzyme is the most important action to take to prevent hair loss?
No they didn’t have normal levels of DHT, 5AR2 makes up 3/4 approx of all the dht in the body. Do not think of the math, unless your planning to use TRT dosages that put you out of the natural range, your should be fine with finasteride+ minoxidil with Trentinion + micorneedling.
"finasteride can maintain (meaning keeping you at baseline which is the day you start)"
I have been taking finasteride for 3 months. Between 2 and 3 months I experienced a deterioration, miniaturization of the hair on my temple. Does this mean, in my case, the sensitivity to androgens is too high for Finasteride to stop? I decided to connect dutasteride 3 times a week, and on the rest of the days continue finasteride to stop
i just want to double my test levels from 500 ng/dl to 1000. I am worried because would that not double my dht levels. However someone said that isn’t always the case?
Yes, there should be no improvement, but there should be no deterioration either. Finasteride didn't stop my hair from miniaturizing further. So he didn't stop ... I don't expect improvements, I just want to stop
Who said there should be no deterioration, finasteride manipulates the anagen cycle causing a possible initial shed which would make you hair worse then baseline until the new hair sprout back. There no argument to this and I will not even spend a second debating that. It has happened to me and many other men
Why would you want to go on trt at a your age with 500ng, you understand that the difference in “muscle mass will be negligible. If you do not have these basic things check you shouldn’t even touch trt...
body fat (10-15%)
weight training (3-6 days a week)
Aerobic exercise (1-3 days a week)
Sleep (7-9 hours every night)
taking the basic supplements, not so much to directly increase test, but indirectly do so through optimizing your body through different parameters ex. Vitamin d3, creatine, vitamin k2, zinc, magnesium, melatonin etc
i had levels in the 900s pre anabolic usage. I now have a high lh reading too, meaning i have
compensated hypogonadism. This is a sign that my body needs higher t levels, especially since my shgb is high too.
You did not understand me. I know about hair cycles and hair loss on finasteride, that's okay. But that's not what I mean. I'm talking about the deterioration of miniaturization. Hope you can tell the difference between hair loss and miniaturization. Look at the photo: my hairline and hair density have not changed in any way, but miniaturization has occurred
Note the orange arrow. The photo does not convey the situation, but my hair has become thinner. And the area of damaged hair has increased
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Ok sure
How do you style your hair? Due to the miniaturization of the hair, I cannot add volume to the bangs. I blow dry it, but it immediately falls off. Hair damaged by Androgenetic Alopecia is awful