Finasteride might effect wisdom teeth?

brentx

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I am NOT sh*tting you, Finasteride slows/stops my wisdom tooth growth!

I've been on this drug for years, and recently had 2 extended periods (about 6 weeks each) OFF it because I was too lazy to order more. I noticed in both instances that my wisdom teeth started moving quite fast. Both times I went back on Finasteride and my teeth stopped moving again!

I thought this was a coincidence, but then I read that Finasteride may reduce FSH levels.

Please excuse the old study..

Effects of the 5?-Reductase Inhibitor Finasteride on Serum Levels of Gonadal, Adrenal, and Hypophyseal Hormones and its Clinical Significance: A Prospective Clinical Study

A Urology Clinic of the Ministry of Health, Ankara Hospital, Ankara, Turkey

Received 16 July 1997;
accepted 14 January 1998.
Available online 30 March 1999.

Abstract

In the present study, we investigated the effects of a steroid 5?-reductase inhibitor, finasteride, when given orally (5 mg/day), on the serum levels of gonadal, hypophyseal, and adrenal hormones and the clinical significance of these effects. Forty-eight patients with a mean age of 63 (range 49–81) were included in the study. All patients had symptoms of benign prostatic hyperplasia. Serum levels of testosterone, dihydrotestosterone, follicle-stimulating hormone (FSH) luteinizing hormone (LH), prolactin, aldosterone, cortisol, and dehydroepiandrosterone were determined before the study. The degree of symptoms in each patient and serum prostate specific antigen levels were determined together with uroflowmetric studies. Sexual status of the patients was also assessed with a self-administered questionnaire. All patients received finasteride, 5 mg/day, for 6 weeks. All of the above mentioned studies were repeated at month 3 and month 6. All of the patients had baseline hormonal values within the normal range. At month 3, the dihydrotestosterone level decreased by 60%, while the testosterone level increased by 15%. FSH and LH levels decreased by 24% and 16%, respectively. The changes in the serum levels of these hormones were further evident at month 6. No significant changes were noted in the serum levels of prolactin, aldosterone, cortisol, and dehydroepiandrosterone. Thirty-six patients (75%) were judged to be potent before the treatment. Finasteride caused erectile dysfunction in 8 patients (22%) by month 3 and in 12 (33%) by month 6. A substantial improvement was noted in symptoms of benign prostatic hyperplasia in all patients. The serum prostate specific antigen level decreased by 42% and 50% at month 3 and at month 6, respectively. Continued administration of finasteride, 5 mg/day alters the serum levels of testosterone, dihydrotestosterone, FSH, and LH significantly. Finasteride also causes sexual dysfunction in a substantial number of patients and should be offered with caution to patients who have an active sexual life.

FSH is the hormone that, among other things, tells the body when to grow new teeth!

Of course, I'm only taking 1.25mg/day, and I don't get any other sides as far I can tell.

Can anyone back me up here? It would surely explain my wisdom tooth movement. It would also scare me to confirm that finasteride is altering hormones apart from DHT.. :(
 

Mew

Experienced Member
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FSH has to do with fertility and sperm production... where did you read it has to do with teeth???

The only reason I could even conceive of the issue you are having via Finasteride, is due to the following... which mention inhibition of 5AR activity by finasteride in gingival and periosteal tissue cells in the mouth:

http://www.ncbi.nlm.nih.gov/pubmed/9477 ... PlusDrugs1

http://www.ncbi.nlm.nih.gov/pubmed/1070 ... d_RVDocSum

Wether that could even influence wisdom teeth growth, who knows. It seems like quite a leap though.
 

brentx

Established Member
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I may have jumped the gun here.. How embarrassing!

I thought FSH was responsible for teething, but I'm obviously mistaken. I must have gotten mixed up for some reason. Maybe I should blame it on brain fog?

Thanks for the studies Mew, I'll have a read :)
 
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