Hello
I am from India and I am doing research in Neuroactive Steroids for the past 18 years. I am not interested in finding a solution for hair loss. I accidentally came to this while searching for medical journals. Anyway for those people who are taking finasteride, I want you to know this before taking this medication. I hope most of you here would have known this, but still I am posting this for people who don’t know about his.
Coming to the matter, finasteride is a potent 5alpha reductase inhibitor. It not only prevents conversion of testosterone into DHT. Latest researches have shown that it also prevents conversion of progesterone to allopregnanolone(Dihydroxy Progesterone). Allopregnanolone is well known neuractive steroid which plays an important role in stress, fear, anxiety… Inhibiting the production will have siginifcant effects in Brain. Further 5alpha reductase may have a role in the formation of Dihydroxy derivative of
other hormones. This is still under research.
I read the all the research papers of Merck carefully found that there is no reference to this anywhere (these can be found in http://www.fda.gov) . I know why Merck has to hide this from FDA. It’s almost 6 years since Merck has got the approval for Propecia, but it had not released any information about this. When you carefully read the transcript of FDA discussion to grant approval, the role of 5alpha reductase in allopregnanolone production is mentioned at only one instance by Dr.Ko. And i feel the issue wasnt dicussed properly.
To my knowledge the human endocrine system is a very sensitive one. From my experience no one can exactly say all the roles of a specific hormone. Any qualified endocrinologist will not advise tampering it with external agents for a long period of time unless it is for a severe case. Before taking this medicine consult with a qualified endocrinologist.
As a consumer you can ask Merck to release information about this, or FDA which approved this drug . If any one who is doing research in this angle please send me a message.
Bye.
I am from India and I am doing research in Neuroactive Steroids for the past 18 years. I am not interested in finding a solution for hair loss. I accidentally came to this while searching for medical journals. Anyway for those people who are taking finasteride, I want you to know this before taking this medication. I hope most of you here would have known this, but still I am posting this for people who don’t know about his.
Coming to the matter, finasteride is a potent 5alpha reductase inhibitor. It not only prevents conversion of testosterone into DHT. Latest researches have shown that it also prevents conversion of progesterone to allopregnanolone(Dihydroxy Progesterone). Allopregnanolone is well known neuractive steroid which plays an important role in stress, fear, anxiety… Inhibiting the production will have siginifcant effects in Brain. Further 5alpha reductase may have a role in the formation of Dihydroxy derivative of
other hormones. This is still under research.
I read the all the research papers of Merck carefully found that there is no reference to this anywhere (these can be found in http://www.fda.gov) . I know why Merck has to hide this from FDA. It’s almost 6 years since Merck has got the approval for Propecia, but it had not released any information about this. When you carefully read the transcript of FDA discussion to grant approval, the role of 5alpha reductase in allopregnanolone production is mentioned at only one instance by Dr.Ko. And i feel the issue wasnt dicussed properly.
To my knowledge the human endocrine system is a very sensitive one. From my experience no one can exactly say all the roles of a specific hormone. Any qualified endocrinologist will not advise tampering it with external agents for a long period of time unless it is for a severe case. Before taking this medicine consult with a qualified endocrinologist.
As a consumer you can ask Merck to release information about this, or FDA which approved this drug . If any one who is doing research in this angle please send me a message.
Bye.
