Flax Lignans Study says its a 5AR Inhibitor

blaze

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Flax Lignans: Cure for hair loss?
Source: Journal of American Dietetic Association 105(5):743-60 (2005)
Source: http://www.acatris.com
A pilot study carried out by Dutch company Acatris, suggests that taking flax lignans could put an end to baldness.
Jocelyn Mathern, Technical Specialist at Acatris, said that androgenetic alopecia (Androgenetic Alopecia), the most common from of hair loss, is a hormonal as well as a genetic issue effecting around 50 per cent of men aged 50 years old or older.
“A potent form of the male hormone testosterone, dihydrotestosterone (DHT), can get inside hair follicles and cause them to shrink and produce thinner hair and eventually none at all,â€￾ said Mathern.
The main flax lignan, secoisolariciresinol diglucoside (SDG), can help prevent this by inhibiting production of the enzyme that converts testosterone into DHT, called 5-alpha reductase.
The study took place at a health company in Taiwan over a six-month period. Ten male sufferers of androgenetic alopecia aged between 20 and 70 years received a 50mg daily dose of SDG.
The condition of their hair was documented at the beginning of the study by photographs and the men measured their hair loss throughout the period by counting the number of hairs on their pillows each morning.
Initial effects of the flax lignans were noticed on average one to two months into the study. At the end of the period, eight of the participants reported a modest improvement in their hair loss condition, one reported a great improvement and one reported no effect at all. The more severe the participant's hair loss was at the start of the trial, the more noticeable the improvement. Half the subjects also noted decreased oil secretion in their scalp. No adverse effects were reported.
“This pilot study confirms earlier research on flax lignans with respect to their promise in the care of Androgenetic Alopecia and without the sometimes harmful effects of a prescription medication,â€￾ said Mathern.
Result's from the pilot study indicate that Acatris will be sponsoring a clinical trial at a research centre in Maastricht, The Netherlands, later this year.


Anyone think there is any truth to this?
 

Armando Jose

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Half the subjects also noted decreased oil secretion in their scalp
A lot of time sebum have a role in improvement of hair loss. What a acoincidence!

study by photographs and the men measured their hair loss throughout the period by counting the number of hairs on their pillows each morning
A special method, counting hair in the morning, by whom?

Result's from the pilot study indicate that Acatris will be sponsoring a clinical trial at a research centre in Maastricht, The Netherlands, later this year.
Where is the study?, they mentioned 2005?

Armando
 

abcdefg

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10 people? I wouldnt place much if any stock in that study. Taiwan and with 10 people at some health company? Lets wait for real research before we all start throwing propecia in the garbage and start taking flax seeds.
 

purecontrol

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So far all the people using this for hair loss that I have read are reporting hair loss, so it is either working or making it worse.
 

abcdefg

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This site has brown and gold flax seeds
http://www.bulkfoods.com/search_results ... amTxt=1607
so all this study did was give enough flax seed to get 50sdg?

One more thing it says flaxseed can inhibit the enzyme that converts testosterone to dht. Thats exactly what finasteride does already so flaxseed would have the same sides and they would be as bad as finasteride if it works as good.
 

michael barry

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The study should have simply taken the before and after serum levels of DHT the men had and seen how much reduction there was.


If there is less sebum, it could mean the flax either inhibits or partially inhibits type one alpha five reductase. But type two is the important kind to inhibit for hair.


Flax probably does have "some" effect on type two alpha five, but I doubt its as much as finasteride. The thing is, if the company promoting it really thought it did, they'd be all to happy to measure for serum decreases in DHT, but they did not.
 

abcdefg

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Its hard to believe we dont have more studies on body hair and its reaction to dht. Is anyone looking at the molecular pathways of what dht does exactly to make body hair grow but scalp hair miniaturize? thats a pretty key piece to this puzzle I think. Another key piece is the stupid immune system, but our effort is probably better spent elsewhere considering how many diseases are related to the immune system and how bad our current understanding is of it.
 
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