Follistatin

[squeegee]

Any news when they will release that to the public??

http://www.freepatentsonline.com/20020157126.html

Hair growth control by follistatin
Accession number;04A0734661
Title;Hair growth control by follistatin
Author;NAKAMURA MOTONOBU(Kyoto Univ., Graduate School of Medicine, JPN) MIYACHI YOSHIKI(Kyoto Univ., Graduate School of Medicine, JPN)
Journal Title;Inflammation and Regeneration
Journal Code:Y0899A
ISSN:1346-8022
VOL.24;NO.5;PAGE.573-577(2004)
Figure&Table&Reference;FIG.5, REF.13
Pub. Country;Japan
Language;Japanese
Abstract;Members of the TGF-.BETA./BMP family such as BMP-4 and TGF.BETA.-1,2 are involved in the control of hair follicle morphogenesis. This prompted us to explore the role of TGF-.BETA./BMP family member activin and its antagonist follistatin in pelage hair follicle development. Here, we show that during hair follicle development, follistatin mRNA is prominently expressed by hair matrix and outer root sheath keratinocytes as well as by interfollicular epidermis, whereas activin .BETA.A-mRNA is mainly expressed in dermal papilla cells. Compared to age-matched wild-type controls, both follistatin knockout mice and activin .BETA.A transgenic mice show a significant retardation of hair follicle morphogenesis. Treatment of wild-type, embryonic skin explants with follistatin protein stimulates hair follicle development. This effect is inhibited by the addition of recombinant activinA protein. These observations suggest that follistatin and activin interaction plays an important role both in hair follicle development and may be exploited as a regenerative treatment for patients with alopecia. (author abst.)

http://www.fasebj.org/cgi/content/full/17/3/497?ck=nck

Since Follistatin proteins have very small molecular weights, http://www.biolreprod.org/cgi/reprint/60/1/8.pdf , they may be a good target for a topical treatment for conditions of the hair.

http://www.prosource.net/article-2008-b ... e-gain.jsp

they were suppose to release it is on the first but still waiting. This product look really promising.

 

[chore boy]

Kudos to johnny b at Regrowth for this.

Results showed as predicted, a zero level of follistatin at baseline with a myostatin level of 46 pg/ml, 12 hours after Folstaxan dosing. Serum follistatin measured 57.1 pg/ml with a decline of myostatin to 34 pg/m1, 24 hours after the initial dosing, follistatin levels began to predictably drop from the time of initial dosing to 11.4 pg/ml. Yet myostatin continued to decline slightly with a 24-hour level of 31 pg/ml. These results clearly indicate that a fertile egg yolk powder properly processed to preserve active follistatin, when orally ingested, results in detectable serum follistatin. Furthermore, this resultant follistatin presence has significant pharmacokinetic activity is shown by the hormonal down regulation of serum follistatin

http://folstaxan.com/athletes/athletes.htm


Quote--

"Folstaxan appears to elevate Follistatin which in several peer reviewed studies has been shown to reduce circulating Myostatin"

http://forum.bodybuilding.com/archive/i ... 24271.html

Hair growth control by follistatin

Abstract;Members of the TGF-.BETA./BMP family such as BMP-4 and TGF.BETA.-1,2 are involved in the control of hair follicle morphogenesis. This prompted us to explore the role of TGF-.BETA./BMP family member activin and its antagonist follistatin in pelage hair follicle development. Here, we show that during hair follicle development, follistatin mRNA is prominently expressed by hair matrix and outer root sheath keratinocytes as well as by interfollicular epidermis, whereas activin .BETA.A-mRNA is mainly expressed in dermal papilla cells. Compared to age-matched wild-type controls, both follistatin knockout mice and activin .BETA.A transgenic mice show a significant retardation of hair follicle morphogenesis. Treatment of wild-type, embryonic skin explants with follistatin protein stimulates hair follicle development. This effect is inhibited by the addition of recombinant activinA protein. These observations suggest that follistatin and activin interaction plays an important role both in hair follicle development and may be exploited as a regenerative treatment for patients with alopecia.

http://sciencelinks.jp/j-east/article/2 ... 734661.php